Results 1 to 10 of about 29,995 (142)
Cyclic AMP response element-binding protein (CREB) transcription factor in astrocytic synaptic communication [PDF]
Frontiers in Synaptic Neuroscience, 2023 Astrocytes are known to actively participate in synaptic communication by forming structures called tripartite synapses. These synapses consist of presynaptic axon terminals, postsynaptic dendritic spines, and astrocytic processes where astrocytes ...
Jooyoung Kim, Bong-Kiun Kaang
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HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein [PDF]
Frontiers in Aging Neuroscience, 2022 HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming.
Jenny Shrestha +26 more
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Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling [PDF]
EBioMedicine, 2015 Retinal neovascularization is the most common cause of moderate to severe vision loss in all age groups. Despite the use of anti-VEGFA therapies, this complication continues to cause blindness, suggesting a role for additional molecules in retinal ...
Nikhlesh K. Singh +3 more
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Cyclic-AMP response element binding protein (CREB) in the neutrophils of depressed patients. [PDF]
Psychiatry Res, 2011 Cyclic-AMP response element binding (CREB) protein regulates the expression of many genes involved in the pathophysiology of depression. Increased CREB levels were found in the brain of antidepressant-treated rats and decreased protein and mRNA expression of CREB was reported in the postmortem brain of depressed suicide victims.
Ren X, Dwivedi Y, Mondal AC, Pandey GN.
europepmc +4 more sources
Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models [PDF]
Korean Journal of Anesthesiology, 2019 Background The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline.
Yumi Kim +8 more
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Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. [PDF]
PLoS ONE, 2010 Activating transcription factor 1 (ATF1) and the closely related proteins CREB (cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP transcription factors that play critical roles in ...
Naval P Shanware +5 more
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Experimental Hematology & Oncology, 2022 Background The protein kinase A (PKA)/cAMP response element-binding protein (CREB) has been suggested to be related to the inhibition of the proliferation of non-small cell lung cancer (NSCLC) cells.
Jae Heun Chung +14 more
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Regulation of cyclic AMP response element‐binding protein during neuroglial interactions [PDF]
Journal of Neurochemistry, 2016 AbstractCommunications between neurons and glial cells play an important role in regulating homeostasis in the central nervous system. cAMP response element‐binding protein (CREB), a transcription factor, is down‐regulated by neurotoxins, which are known to be released by activated glial cells.
LiMei, Qin +2 more
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JCI Insight, 2021 Obesity, a major health care issue, is characterized by metabolic abnormalities in multiple tissues, including the skeletal muscle. Although dysregulation of skeletal muscle metabolism can strongly influence the homeostasis of systemic energy, the ...
Bo Xu +9 more
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Cell Reports, 2023 Summary: Remyelination after white matter injury (WMI) often fails in diseases such as multiple sclerosis because of improper recruitment and repopulation of oligodendrocyte precursor cells (OPCs) in lesions.
Kimberly K. Hoi +7 more
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