Cyclic AMP response element-binding protein (CREB) transcription factor in astrocytic synaptic communication. [PDF]
Front Synaptic Neurosci, 2022 Astrocytes are known to actively participate in synaptic communication by forming structures called tripartite synapses. These synapses consist of presynaptic axon terminals, postsynaptic dendritic spines, and astrocytic processes where astrocytes release and receive transmitters.
Kim J, Kaang BK.
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Cyclic AMP response element-binding protein is required in excitatory neurons in the forebrain to sustain wakefulness. [PDF]
Sleep, 2021 Abstract The molecular and intracellular signaling processes that control sleep and wake states remain largely unknown. A consistent observation is that the cyclic adenosine monophosphate (AMP) response element-binding protein (CREB), an activity-dependent transcription factor, is differentially activated during sleep and wakefulness ...
Wimmer ME, Cui R, Blackwell JM, Abel T.
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HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein. [PDF]
Front Aging Neurosci, 2022 HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming. This led to decreased ATP levels, lower mitochondrial DNA copy numbers, and loss of mitochondria cristae, all-
Shrestha J +14 more
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Cyclic-AMP response element binding protein (CREB) in the neutrophils of depressed patients. [PDF]
Psychiatry Res, 2011 Cyclic-AMP response element binding (CREB) protein regulates the expression of many genes involved in the pathophysiology of depression. Increased CREB levels were found in the brain of antidepressant-treated rats and decreased protein and mRNA expression of CREB was reported in the postmortem brain of depressed suicide victims.
Ren X, Dwivedi Y, Mondal AC, Pandey GN.
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Regulation of Cyclic AMP-Response Element Binding Protein Zhangfei (CREBZF) Expression by Estrogen in Mouse Uterus. [PDF]
Dev Reprod, 2018 CREBZF (cAMP-response element binding protein zhangfei) is a member of ATF/CREB family, and which regulates various cellular functions by suppressing major factors with direct interaction. In this study, we have examined the expression of CREBZF on mouse endometrium during uterus estrous cycles and estrogen (E2) treatment.
Jang H.
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Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia. [PDF]
J Affect Disord, 2014 Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two brain areas implicated in these disorders, i.e ...
Ren X +5 more
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Application of Degradation of Cyclic-AMP Response Element Binding Protein for the Potential Treatment of Cancer. [PDF]
ACS Med Chem Lett, 2022 Kargbo RB.
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Regulation of cyclic AMP response element‐binding protein during neuroglial interactions [PDF]
Journal of Neurochemistry, 2016 AbstractCommunications between neurons and glial cells play an important role in regulating homeostasis in the central nervous system. cAMP response element‐binding protein (CREB), a transcription factor, is down‐regulated by neurotoxins, which are known to be released by activated glial cells.
Ron J. Bouchard +4 more
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Expression cloning of a zinc-finger cyclic AMP-response-element-binding protein [PDF]
Biochemical Journal, 1995 In response to specific extracellular signals, intracellular cyclic AMP levels increase, leading to a variety of responses including the alteration of transcription of many eukaryotic genes. This transcriptional effect is frequently mediated through the cyclic AMP-response element (CRE) motif T(T/G)ACGTCA. Using an expression screening approach we have
Richard M. O'Brien +4 more
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A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression [PDF]
Cancer Research, 2004 Abstract Tumor microenvironment controls the selection of malignant cells capable of surviving in stressful and hypoxic conditions. The transcription factor, cyclic AMP-responsive element binding (CREB) protein, activated by multiple extracellular signals, modulates cellular response by regulating the expression of a multitude of genes ...
Jasmine Jacob-Hirsch +8 more
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