Results 31 to 40 of about 30,015 (162)
A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression [PDF]
Cancer Research, 2004 Abstract Tumor microenvironment controls the selection of malignant cells capable of surviving in stressful and hypoxic conditions. The transcription factor, cyclic AMP-responsive element binding (CREB) protein, activated by multiple extracellular signals, modulates cellular response by regulating the expression of a multitude of genes ...
Rinat, Abramovitch +8 more
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Cyclic AMP response element binding protein (CREB) regulation by asbestos
The FASEB Journal, 2007 Inhalation of asbestos fibers has been associated with the development of lung cancers and mesotheliomas. Little is known about the crucial cellular mechanisms that initiate and drive the processes of carcinogenesis. Because CREs (Ca 2+ /cAMP response elements) are found in the promoters of ...
Arti Shukla +4 more
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Frontiers in Neuroscience, 2019 In studies on the treatment of Alzheimer’s disease (AD), in which cognition is enhanced even modestly or selectively, it has been considered that the histamine H3 receptor (H3R) may be a potential target. In this study, we aimed at evaluating the ability
Linlin Wang +7 more
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Frontiers in Pharmacology, 2022 Lag periods of therapeutic efficacy cause poor compliance of patients, which has made solutions for rapid antidepressants the most urgent need in the depression study field at present.
Li Ren +8 more
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Molecular Determinants of the Spacing Effect
Neural Plasticity, 2012 Long-term memory formation is sensitive to the pattern of training sessions. Training distributed over time (spaced training) is superior at generating long-term memories than training presented with little or no rest interval (massed training).
Faisal Naqib +2 more
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Neuropsychiatric Disease and Treatment, 2015 Yu Zhao,1 Ming Xiao,2 Wenbo He,3 Zhiyou Cai3 1Department of Neurology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; 2Department of Anatomy, Nanjing Medical ...
Zhao Y, Xiao M, He W, Cai Z
doaj
Biomolecules, 2020 Background: MUC2, a major component of the mucus layer in the intestine, is associated with antimicrobial activity and gut immune system function. Currently, mucin is mainly known for its critical function in defense against toxic molecules and pathogens.
Seongho Ma, Jiah Yeom, Young-Hee Lim
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Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes
Cancer Cell International, 2021 The transcription factor cyclic-AMP response element-binding protein 1 (CREB1) responds to cAMP level and controls the expression of target genes, which regulates nutrition partitioning.
Tianyu Zheng +14 more
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Growth Suppression of Lung Cancer Cells by Targeting Cyclic AMP Response Element-Binding Protein [PDF]
Cancer Research, 2008 Abstract Genes regulated by cyclic AMP–response element-binding protein (CREB) have been reported to suppress apoptosis, induce cell proliferation, and mediate inflammation and tumor metastasis. However, it is not clear whether CREB is critically involved in lung carcinogenesis. We found that non–small cell lung cancer (NSCLC) cell lines
Sita, Aggarwal +4 more
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Sleep is enhanced in aged male mice that overexpress calcium/calmodulin-dependent protein kinase IV
Frontiers in NeuroscienceThe dysregulation of sleep–wake patterns that occurs during aging is well documented and coincides with changes in intracellular signaling pathways that regulate sleep, such as the calcium/calmodulin-dependent protein kinase (CaMKII)/cyclic-AMP response ...
Sierra P. Feeney +10 more
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