Results 31 to 40 of about 29,900 (296)

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling

Cell Death and Disease, 2023
Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain elusive.
Zhangchu Jin, Zhehua Shao, Shiyi Yang, Anyi Guo, Yinling Han, Yinfang Wu, Yun Zhao, Yanping Wu, Jiaxin Shen, Min Zhang, Xueqin Zhan, Wenqi Diao, Songmin Ying, Chao Zhang, Wen Li, Huahao Shen, Zhihua Chen, Fugui Yan   +17 more
doaj   +1 more source

Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB

EBioMedicine, 2017
Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg)
Antony Symons, Wenjun Ouyang
doaj   +1 more source

Ending Restenosis: Inhibition of Vascular Smooth Muscle Cell Proliferation by cAMP

Cells, 2019
Increased vascular smooth muscle cell (VSMC) proliferation contributes towards restenosis after angioplasty, vein graft intimal thickening and atherogenesis.
Sarah A. Smith, Andrew C. Newby, Mark Bond   +2 more
doaj   +1 more source

Retrieval of Consolidated Spatial Memory in the Water Maze Is Correlated with Expression of pCREB and Egr1 in the Hippocampus of Aged Mice

Dementia and Geriatric Cognitive Disorders Extra, 2013
Objective: To study the relationship of the expression of phosphorylated cyclic AMP response element-binding protein (pCREB) and early growth response protein 1 (Egr1) in the hippocampus of aged mice with retrieval of consolidated spatial memory in a ...
GuoXia Zhou, WanXia Xiong, XiaoGuang Zhang, ShengJin Ge   +3 more
doaj   +1 more source

From Drosophila development to adult: clues to Notch function in long-term memory

Frontiers in Cellular Neuroscience, 2013
Notch is a cell surface receptor that is well known to mediate inter-cellular communication during animal development. Data in the field indicate that it is also involved in the formation of long-term memory (LTM) in the fully developed adults and in ...
Jiabin eZhang, Jerry eYin, Cedric S Wesley   +2 more
doaj   +1 more source

Pharmacological and Molecular Evidence of Neuroprotective Curcumin Effects Against Biochemical and Behavioral Sequels Caused by Methamphetamine: Possible Function of CREB-BDNF Signaling Pathway

Basic and Clinical Neuroscience, 2021
Introduction: The neuroprotective impact of curcumin and the role of CREB (Cyclic AMP Response Element Binding protein)-BDNF (Brain-Derived Neurotrophic Factor) signaling pathway was evaluated in Methamphetamine (METH)-induced neurodegeneration in rats ...
Mina Gholami, Farzad Hozuri, Setayesh Abdolkarimi, Mahsa Mahmoudi, Majid Motaghinejad, Sepideh Safari, Samira Sadr   +6 more
doaj  

Global conformational selection and local induced fit for the recognition between intrinsic disordered p53 and CBP. [PDF]

PLoS ONE, 2013
The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator binding domain (NCBD) of cyclic-AMP response element binding protein (CBP) and activate transcription.
Qingfen Yu, Wei Ye, Wei Wang, Hai-Feng Chen   +3 more
doaj   +1 more source

The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism [PDF]

Nature Medicine, 2011
Here we report that the transcription factor cyclic AMP-responsive element-binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H-deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance catalyzed by lipoprotein lipase (Lpl), partly due to ...
Jung Hoon, Lee, Petros, Giannikopoulos, Stephen A, Duncan, Jian, Wang, Christopher T, Johansen, Jonathan D, Brown, Jorge, Plutzky, Robert A, Hegele, Laurie H, Glimcher, Ann-Hwee, Lee   +9 more
openaire   +2 more sources

The Circular RNA Circ_0043947 Promoted Gastric Cancer Progression by Sponging miR-384 to Regulate CREB1 Expression

Gut and Liver
Background/Aims: The occurrence and development of circular RNAs in gastric cancer (GC) has attracted increasing attention. This study focused on investigating the biological role and molecular mechanism of circ_0043947 in GC.
Chongxin Zhang, Fan Zhang, Yukun Li, Pengfei Yang, Yang Liu, Wenxiao Yang   +5 more
doaj   +1 more source

A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression [PDF]

Cancer Research, 2004
Abstract Tumor microenvironment controls the selection of malignant cells capable of surviving in stressful and hypoxic conditions. The transcription factor, cyclic AMP-responsive element binding (CREB) protein, activated by multiple extracellular signals, modulates cellular response by regulating the expression of a multitude of genes ...
Rinat, Abramovitch, Einat, Tavor, Jasmine, Jacob-Hirsch, Evelyne, Zeira, Ninette, Amariglio, Orit, Pappo, Gideon, Rechavi, Eithan, Galun, Alik, Honigman   +8 more
openaire   +2 more sources