Results 41 to 50 of about 30,015 (162)
GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer. [PDF]
PLoS ONE, 2016 Overexpression or activation of cyclic AMP-response element-binding protein (CREB) has been known to be involved in several human malignancies, including lung cancer.
Sin-Aye Park +3 more
doaj +1 more source
Recurrent airway obstruction in horses - an allergic inflammation: a review
Veterinární Medicína, 2011 Recurrent airway obstruction (RAO), also known as heaves, is a debilitating and incurable disease of the equine airway. Affected horses develop bronchoconstriction and neutrophilic airway inflammation as a result of exposure to specific airborne ...
G. Moran, H. Folch
doaj +1 more source
Frontiers in Oncology, 2020 To achieve a cure for metastatic breast cancer, further understanding of molecular drivers of the metastatic cascade is essential. Currently, chemotherapy regimens include doxorubicin and paclitaxel which act in part by inducing the unfolded protein ...
Annat Raiter +8 more
doaj +1 more source
The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells. [PDF]
PLoS ONE, 2012 Migration-proliferation dichotomy is a common mechanism in gliomagenesis; however, an understanding of the exact molecular mechanism of this "go or grow" phenomenon remains largely incomplete.
Xiaochao Tan +9 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Stroke is a major cause of death and disability throughout the world. A combination of Panax Ginseng and Ginkgo biloba extracts (CGGE) is an effective treatment for nervous system diseases, but the neuroprotective mechanism underlying CGGE remains ...
Aimei Zhao +13 more
doaj +1 more source
Decreased CREB levels suppress epilepsy
Neurobiology of Disease, 2012 Epilepsy is a common neurologic disorder yet no treatments aimed at preventing epilepsy have been developed. Several molecules including genes containing cAMP response elements (CREs) in their promoters have been identified that contribute to the ...
Xinjian Zhu +3 more
doaj +1 more source
Sustained CREB phosphorylation by lipid-peptide liquid crystalline nanoassemblies
Communications Chemistry, 2023 Cyclic-AMP-response element-binding protein (CREB) is a leucine zipper class transcription factor that is activated through phosphorylation. Ample CREB phosphorylation is required for neurotrophin expression, which is of key importance for preventing and
Yu Wu +6 more
doaj +1 more source
Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription
eLife, 2019 How huntingtin (HTT) triggers neurotoxicity in Huntington’s disease (HD) remains unclear. We report that HTT forms a transcription-coupled DNA repair (TCR) complex with RNA polymerase II subunit A (POLR2A), ataxin-3, the DNA repair enzyme polynucleotide ...
Rui Gao +14 more
doaj +1 more source
GRM7 Regulates Embryonic Neurogenesis via CREB and YAP
Stem Cell Reports, 2015 Metabotropic glutamate receptor 7 (GRM7) has recently been identified to be associated with brain developmental defects, such as attention deficit hyperactivity disorder (ADHD) and autism.
Wenlong Xia, YanLi Liu, Jianwei Jiao
doaj +1 more source
Scientific Reports, 2022 Studies suggest that the scaffolding protein, postsynaptic density protein-95 (PSD-95), is involved in multiple neurological dysfunctions. However, the role of PSD-95 in the anterior cingulate cortex (ACC) in neuropathic pain (NP) has not been ...
Ang Li +9 more
doaj +1 more source