ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A [PDF]
Marine Drugs, 2018 Our understanding of autophagy and lysosomal function has been greatly enhanced by the discovery of natural product structures that can serve as chemical probes to reveal new patterns of signal transduction in cells.
Xuemei Wan +6 more
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Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi [PDF]
Molecules, 2018 Cyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the peptide structure.
Xiaohan Wang +4 more
doaj +5 more sources
Biochemical Studies of the Lagunamides, Potent Cytotoxic Cyclic Depsipeptides from the Marine Cyanobacterium <em>Lyngbya majuscula</em> [PDF]
Marine Drugs, 2012 Lagunamides A (<strong>1</strong>) and B (<strong>2</strong>) are potent cytotoxic cyclic depsipeptides isolated from the filamentous marine cyanobacterium, <em>Lyngbya majuscula</em>, from Pulau Hantu, Singapore ...
David Tai Leong +3 more
doaj +2 more sources
Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp. [PDF]
Marine Drugs, 2015 Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were ...
Munhyung Bae +4 more
doaj +2 more sources
Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides [PDF]
BMC BiotechnologyBackground The Arctic environment, characterized by extreme conditions, hosts a largely untapped reservoir of fungal communities that have adapted to these harsh conditions by producing specialized bioactive secondary metabolites. Among these, Acremonium
Sailesh Maharjan +5 more
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Cytotoxic and Antibacterial Cyclodepsipeptides from an Endophytic Fungus Fusarium avenaceum W8 [PDF]
MoleculesSeven cyclic depsipeptides, including two new cyclic pentadepsipeptides avenamides A (1) and B (2), were isolated from a plant-derived fungus Fusarium avenaceum W8 by using the bioassay-guided fractionation method.
Zimo Wang +5 more
doaj +2 more sources
Cyanobacterial Peptides in Anticancer Therapy: A Comprehensive Review of Mechanisms, Clinical Advances, and Biotechnological Innovation [PDF]
Marine DrugsCyanobacteria-derived peptides represent a promising class of anticancer agents due to their structural diversity and potent bioactivity. They exert cytotoxic effects through mechanisms including microtubule disruption, histone deacetylase inhibition ...
Heayyean Lee +2 more
doaj +2 more sources
Elucidation of novel turnagainolides and their biosynthetic gene cluster in Bacillus subtilis [PDF]
Applied and Environmental MicrobiologyTurnagainolides represent a unique class of cyclic depsipeptides characterized by the presence of a rare (E)-3-hydroxy-5-phenylpent-4-enoic acid (Hppa) residue, exhibiting diverse bioactivities.
Peng Li +8 more
doaj +2 more sources
Total Syntheses of Colletopeptide A and Colletotrichamide A
Molecules, 2023 The first total syntheses of cyclic depsipeptides colletopeptide A and colletotrichamide A, have been accomplished. The key advanced intermediate, a cyclic tridepsipeptide derivative, was constructed using a sequence of transformations that features ...
Jing Chen +4 more
doaj +1 more source
Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials
Molecules, 2023 Cancer is currently considered one of the most threatening diseases worldwide. Diet could be one of the factors that can be enhanced to comprehensively address a cancer patient’s condition.
Plinio A. Trinidad-Calderón +2 more
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