Results 41 to 50 of about 3,649 (185)

Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. [PDF]

, 2013
The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series.
A. D. Rodriguez, A. M. S. Mayer, N. Fusetani, TAGLIALATELA SCAFATI, ORAZIO   +3 more
core   +2 more sources

High‐Throughput Engineering and Modification of Non‐Ribosomal Peptide Synthetases Based on Golden Gate Assembly

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
A Golden Gate Assembly (GGA)‐based method was developed for the efficient assembly of natural and engineered non‐ribosomal peptide synthetases (NRPS). This method has enabled the creation of NRPS libraries to generate novel peptides in high‐throughput as well as the targeted derivatisation of natural products (NPs).
Adrian Podolski, Timon A. Lindeboom, Leonard Präve, Maryam Dehghan, Hannah A. Minas, Janik Kranz, Daniel Schindler, Helge B. Bode   +7 more
wiley   +2 more sources

AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells. Interference with the Akt/NF-kB survival pathway [PDF]

, 2005
8 páginas, 5 figuras -- PAGS nros. 572-579Clinical treatment of B-cell chronic lymphocytic leukemia (B-CLL) is limited by the progressive drug resistance and nonselectivity of most drugs towards malignant cells.
Escobar-Díaz, Elisabeth, López-Martín, E.M., Hernández del Cerro, Mercedes, Puig-Kröger, Amaya, Soto-Cerrato, V., Montaner, B., Giralt, Ernest, García-Marco, José A., Pérez-Tomás, R., García-Pardo, Angeles   +9 more
core   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Fungal cyclooligomer depsipeptides: From classical biochemistry to combinatorial biosynthesis [PDF]

, 2011
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Döhren, Hans von, Molnár, István, Müller, Jane, Süßmuth, Roderich D.   +3 more
core   +2 more sources

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Biomedical and therapeutic applications of biosurfactants [PDF]

, 2010
During the last years, several applications of biosurfactants with medical purposes have been reported. Biosurfactants are considered relevant molecules for applications in combating many diseases and as therapeutic agents due to their antibacterial ...
A. Bernheimer, A. Fiechter, A. Flasz, A. Singh, A.B. Moldes, A.L. Moyne, B. Angelova, B. Gan, C. Carrillo, C. Delden Van, C. Heinemann, C.G. Hoogmoed Van, C.L. Wang, C.N. Mulligan, D. Kitamoto, D. Kitamoto, D. Vollenbroich, D. Vollenbroich, D.J. Bidel, D.R. Mack, F. Ahimou, F. Besson, F. Ramisse, G. Reid, G. Reid, G. Reid, G. Reid, G. Reid, H. Isoda, H. Isoda, H. Itokawa, H. Sano, H.J. Busscher, H.J. Busscher, H.J. Busscher, I. Grangemard, I.M. Banat, I.M. Banat, I.M. Banat, I.N.A. Bogaert Van, J. Gerard, J. Im, J.D. Desai, J.D. Hamme Van, J.D. Sheppard, J.H. Im, J.R. Mireles, J.R. Wright, K. Das, K. Das, K. Jenny, K. Kim, K. Millsap, K. Mittenbuhler, L. Thimon, L.R. Rodrigues, L.R. Rodrigues, L.R. Rodrigues, L.R. Rodrigues, L.R. Rodrigues, L.R. Rodrigues, L.R. Rodrigues, L.R. Rodrigues, L.R. Rodrigues, M. Benincasa, M. Konishi, M. Morikawa, M. Shibahara, M. Velraeds, M. Velraeds, M. Velraeds, M. Velraeds, M. Yakimov, N. G. Dehghan, N. Kosaric, N. Kosaric, N. Naruse, O.M.P. Rivera, P. Gotek, P. Singh, R. Maier, R. Makkar, R. Sen, R.M. Maier, R.T. Otto, S. Boris, S. Cameotra, S. Cameotra, S. Igarashi, S. Ito, S. Joshi, S. Lang, S. Lin, S. Lin, S. Mukherjee, T. I. Pratt, T. Kikuchi, T. Kikuchi, T. Neu, T. Nielsen, T. Sudo, V. Shah, X. Zhao, X. Zhao, Y. Inoh, Y. Inoh, Y. Ishigami, Y. Kameda, Y. Maitani, Y. Tanaka, Y. Uchida, Y. Uchida, Y. Ueno, Y. Ueno, Y. Wakamatsu   +114 more
core   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Investigation of the N-Terminus Amino Function of Arg10-Teixobactin

Molecules, 2017
Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis.
Shimaa A. H. Abdel Monaim, Sikabwe Noki, Estelle J. Ramchuran, Ayman El-Faham, Fernando Albericio, Beatriz G. de la Torre   +5 more
doaj   +1 more source

Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry. [PDF]

, 2016
Flow chemistry has been successfully integrated into the synthesis of a series of cyclooligomeric depsipeptides of three different ring sizes including the natural products beauvericin (1 a), bassianolide (2 b) and enniatin C (1 b).
Agarkov, Albericio, Amblard, Baumann, Baxendale, Carpino, Devos, Feifel, Fernández, Fosgerau, Ghosez, Hamill, Haveaux, Hu, Hu, Jestoi, Jones, Kanaoka, Kanaoka, Kanaoka, Kimmerlin, Kogan, Krause, Lee, Lee, Logrieco, Madry, Matthes, Merrifield, Mikhaleva, Newby, Newby, Nilanonta, Ovchinnikov, Ovchinnikov, Pattabiraman, Qian, Rodriguez, Saaby, Scherkenbeck, Sivanathan, Stockinger, Supothina, Suzuki, Süssmuth, Valera, Vlieghe, Xu, Zhan   +48 more
core   +1 more source