Results 51 to 60 of about 3,649 (185)

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Biosurfactants: potential applications in medicine [PDF]

, 2006
The use and potential commercial application of biosurfactants in the medical field has increased during the past decade. Their antibacterial, antifungal and antiviral activities make them relevant molecules for applications in combating many diseases ...
Banat, Ibrahim M., Oliveira, Rosário, Rodrigues, L. R., Teixeira, J. A.   +3 more
core   +1 more source

Cyclic peptides and depsipeptides from cyanobacteria: A review

Journal of Industrial Microbiology, 1996
An elaborate array of structurally-novel and biologically-active cyclic peptides and depsipeptides are found in blue-green algae (cyanobacteria). Several of these compounds possess structures that are similar to those of natural products from marine invertebrates.
openaire   +2 more sources

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond-Forming Non-ribosomal Peptide Synthetase Module [PDF]

, 2011
Cryptophycins (Crp) are a group of cyanobacterial depsipeptides with activity against drug-resistant tumors. Although they have been shown to be promising, further efforts are required to return these highly potent compounds to the clinic through a new ...
Bolduc, Kyle L., Ding, Yousong, Håkansson, Kristina, Rath, Christopher M., Sherman, David H.   +4 more
core   +1 more source

Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama, Hikari Sada, Takeshi Nanjo   +2 more
wiley   +1 more source

Solonamide B Inhibits Quorum Sensing and Reduces Staphylococcus aureus Mediated Killing of Human Neutrophils [PDF]

, 2014
Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a serious human pathogen, and particularly the spread of community associated (CA)-MRSA strains such as USA300 is a concern, as these strains can cause severe infections in otherwise ...
A Nielsen, AE Clatworthy, AI Hidron, Anita Nielsen, AW Bernheimer, B Amulic, BA Diep, BC Herold, BE Ragle, DA Rasko, Dorte Frees, E Geisinger, EA George, FD Lowy, FD Lowy, G Ji, G Ji, G Sakoulas, G Werner, GJ Lyon, GJ Lyon, GJ Moran, GL Archer, Gunnar F. Kaufmann, GW Krucke, GY Cheung, Hanne Frøkiær, Hanne Ingmer, J Bubeck Wardenburg, JA Loughman, L Cegelski, L Jelsbak, Lone Gram, M Hentzer, M Mansson, M Otto, M Shoham, Maria Månsson, Martin S. Bojer, N Firon, P Mayville, P Recsei, PF Chan, R Wang, Richard P. Novick, RL Thompson, RO Jensen, RP Novick, RP Novick, RP Novick, S Bhakdi, S Bhakdi, S Deresinski, S Jarraud, SF Graves, SV Kazakova, SY Queck, Thomas O. Larsen, TM Jarry, WC Chan   +59 more
core   +2 more sources

Controlling production of brominated cyclic depsipeptides by Pseudoalteromonas maricaloris KMM 636T [PDF]

Letters in Applied Microbiology, 2005
This study aims at evaluating the impact of the nutrient medium components on the in vitro production of the cytotoxic alterochromides.The employment matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) facilitated the identification of a range of brominated cyclic depsipeptides with molecular masses of 843/845, 857/859 and 922/924 ...
Sobolevskaya, M. P., Smetanina, O. F., Speitling, M., Shevchenko, L. S., Dmitrenok, P. S., Laatsch, H., Kuznetsova, T. A., Ivanova, E., Elyakov, G. B.   +8 more
openaire   +4 more sources

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Prva potpuna sinteza i biološko vrednovanje himenamida E [PDF]

, 2006
A new potent bioactive, proline-rich cyclic heptapeptide hymenamide E (13) was synthesized using the solution phase technique by cyclization of the linear peptide Boc-Phe-Pro-Thr-Thr-Pro-Tyr-Phe-OMe (12) after proper deprotection at carboxyl and amino ...
DEVENDER PATHAK, M. HIMAJA, RAJIV DAHIYA, SUNITA BHATT   +3 more
core   +1 more source