Results 71 to 80 of about 3,649 (185)

Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics [PDF]

, 2009
Novel therapeutic strategies are urgently needed for the treatment of serious diseases caused by viral, bacterial and parasitic infections, because currently used drugs are facing the problem of rapidly emerging resistance.
Bernardini, F, Bisang, C, DeMarco, S J, Gombert, F O, Moehle, K, Obrecht, D, Robinson, J A   +6 more
core   +1 more source

Structure of New Cyclic Depsipeptides, Bu-2841-08 and -10

The Journal of Antibiotics, 1995
The structures of new antibiotics, Bu-2841-08 and -10, have been determined. They are cyclic depsipeptides and the sequence of amino acid residues was established by mass spectral analysis of the hydrolyzed linear peptide and NMR spectral analysis of the parent cyclic peptides.
T, Fukai, J, Kuroda, M, Konishi, T, Nomura, N, Naruse, R, Isobe   +5 more
openaire   +3 more sources

Fish By‐Products Utilization in Food and Health: Extraction Technologies, Bioactive, and Sustainability Challenges

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Fish by‐products, often discarded, are rich sources of bioactive peptides, collagen, and omega‐3s with antioxidant, antihypertensive, and antimicrobial properties. Advanced, sustainable extraction technologies can valorize this waste into functional food, nutraceutical, and biomedical ingredients.
Muhammad Waqar, Nimra Sajjad, Qudrat Ullah, S. S. Vasanthkumar, Faiyaz Ahmed, Worawan Panpipat, Rotimi E. Aluko, Lovedeep Kaur, Manat Chaijan, Temesgen Anjulo Ageru   +9 more
wiley   +1 more source

Origin and characterization of cyclodepsipeptides: Comprehensive structural approaches with focus on mass spectrometry analysis of alkali‐cationized molecular species

Mass Spectrometry Reviews, Volume 44, Issue 6, Page 1013-1098, November/December 2025.
Abstract Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds.
Sophie Liuu, Annelaure Damont, Alain Perret, Olivier Firmesse, François Becher, Gwenaëlle Lavison‐Bompard, Amandine Hueber, Amina S. Woods, Ekaterina Darii, François Fenaille, Jean‐Claude Tabet   +10 more
wiley   +1 more source

UZH: Alma Mater and Birthplace of Polyphor Ltd

CHIMIA, 2008
Daniel and Jean-Pierre Obrecht and Michael Altorfer present a brief account of the role that the Institute of Organic Chemistry, University of Zurich, has played in their scientific and professional development leading ultimately to a successful
Daniel Obrecht, Jean-Pierre Obrecht, Michael Altorfer   +2 more
doaj   +1 more source

Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study [PDF]

, 2016
We describe the qualitative and quantitative analysis of the complexation properties towards cations of a cyclic peptoid hexamer composed of alternating α- and β-peptoid monomers, which bear exclusively chiral (S)-phenylethyl side chains (spe) that have ...
A. A. Edwards, A.-S. Biesse-Martin, Armand, Arnaud-Neu, B. D. Alexander, B. V. Nielsen, Baskin, Baskin, Baskin, Bosque-Sendra, C. Taillefumier, Caumes, Conti, Culf, Culf, D. Mistry, Daily, De Cola, De Cola, De Santis, De Santis, Della Sala, Devarajan, Diamond, Dudek, Durán Merás, E. De Santis, Eberspaecher, G. Siligardi, Gorske, Goutelle, Han, Hinaje, Hioki, Hjelmgaard, Izzo, Javorfi, Kalugin, Kelly, Kirshenbaum, Knight, Knight, L. Waters, Lee, Maayan, Maayan, Maharani, Maulucci, Mishustin, Ovchinnikov, Pigot, R. Hussain, Roy, S. Faure, S. J. Holder, Schettini, Shannon, Shin, Siligardi, Siligardi, Stewart, Sui, Wu, Wu, Yoe, Yoo, Zabrodski, Zeng, Zsila   +68 more
core   +2 more sources

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, Volume 45, Issue 10, Page 1247-1284, October 2025.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.

PLoS ONE, 2016
In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A).
Chelsi D Cassilly, Marcus M Maddox, Philip T Cherian, John J Bowling, Mark T Hamann, Richard E Lee, Todd B Reynolds   +6 more
doaj   +1 more source

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

MedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan, Sana Khurshid, Saud Almawash, Rakesh Kumar, Ammira S. Al‐Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +6 more
wiley   +1 more source

Plitidepsin Has a Safe Cardiac Profile: A Comprehensive Analysis

Marine Drugs, 2011
Plitidepsin is a cyclic depsipeptide of marine origin in clinical development in cancer patients. Previously, some depsipeptides have been linked to increased cardiac toxicity.
Carmen Kahatt, Cinthya Coronado, Pilar Lardelli, Claudia Silvia Corrado, Elena Roy, Vicente Alfaro, Bernardo Miguel-Lillo, Sonia Extremera, Arturo Soto-Matos, Sergio Szyldergemajn   +9 more
doaj   +1 more source