Results 91 to 100 of about 40,137 (294)

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

Kinetics of nitric oxide‐cyclic GMP signalling in CNS cells and itspossible regulation by cyclic GMP [PDF]

, 2002
Victoria Wykes, Tomas C. Bellamy, John Garthwaite   +2 more
openalex   +1 more source

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang   +14 more
wiley   +1 more source

Erratum to: Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture [PDF]

, 2016
John G. McCarron, Susan Chalmers, Calum Wilson, Mairi E. Sandison   +3 more
openalex   +1 more source

Biomimetic Iridium‐Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS‐STING Pathway for Improved Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding, Zhongxiong Fan, Guoyu Xia, Fukai Zhu, Nan Yang, Shujie Yu, Longlong Yuan, Jinyao Li   +7 more
wiley   +1 more source

Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are intracellular mediators of innate immune responses to cytosolic pathogen-derived and host DNA.
Akshay Rohilla, Alok Kumar Singh, Benjamin Koleske, Geetha Srikrishna, William R. Bishai   +4 more
doaj   +1 more source

Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor [PDF]

, 2019
Koji Ozasa, Burcu Temizoz, Takato Kusakabe, Shingo Kobari, Masatoshi Momota, Cevayir Coban, Shuichi Ito, Kouji Kobiyama, Etsushi Kuroda, Ken J. Ishii   +9 more
openalex   +1 more source

High‐Resolution Multispectral Photovoltaic Imagers from Visible to Short‐Wave Infrared

Advanced Science, EarlyView.
We demonstrate a monolithic quad‐spectral imager that seamlessly integrates visible and short‐wave infrared detection on a single chip. Through direct photopatterning of an all‐polymer bulk heterojunction and colloidal quantum dots, the device achieves high‐resolution (640 × 512) imaging across 350–2400 nm, enabling multispectral capture for ...
Wanqing Li, Cheng Bi, Min He, Xiaolong Zheng, Yuning Luo, Yimei Tan, Chenxi Liu, Salihuojia Talanti, Yanfei Liu, Ge Mu, Qun Hao, Kangkang Weng, Xin Tang   +12 more
wiley   +1 more source

Environmental purines decrease Pseudomonas aeruginosa biofilm formation by disrupting c-di-GMP metabolism

Cell Reports
Summary: Cyclic di-guanosine monophosphate (c-di-GMP) is a bacterial second messenger that governs the lifestyle switch between planktonic and biofilm states.
Corey Kennelly, Peter Tran, Arthur Prindle   +2 more
doaj   +1 more source