Results 31 to 40 of about 1,721,329 (334)
Discovery and Characteristics of a Novel Antitumor Cyclopeptide Derived from Shark
Bioengineering, 2023 Peptides pose a challenge in drug development due to their short half-lives in vivo. In this study, we conducted in vitro degradation experiments on SAIF, which is a shark-derived peptide that we previously studied.
Fu Li +9 more
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Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
Beilstein Journal of Organic Chemistry, 2018 The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
doaj +1 more source
Evidence for a novel mechanism of antimicrobial action of a cyclic R-,W-rich hexapeptide. [PDF]
PLoS ONE, 2015 The development of antimicrobial peptides as new class of antibiotic agents requires structural characterisation and understanding of their diverse mechanisms of action. As the cyclic hexapeptide cWFW (cyclo(RRRWFW)) does not exert its rapid cell killing
Kathi Scheinpflug +4 more
doaj +1 more source
Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor
Frontiers in Molecular Biosciences, 2022 The ubiquitin-proteasome system is an essential regulator of many cellular processes including controlling protein homeostasis. The degradation of proteins by the multi-subunit proteasome complex is tightly regulated through a series of checkpoints ...
Dharjath S. Hameed +3 more
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Sweetening Cyclic Peptide Libraries [PDF]
ChemInform, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire +2 more sources
Cyclic Peptides for Drug Development
Angewandte Chemie International Edition, 2023 AbstractCyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years through improved methods for synthesis and drug development have resulted in a steady ...
Ji, Xinjian +2 more
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ACS Macro Letters, 2019 Cyclic peptide-polymer conjugates are capable of self-assembling into supramolecular polymeric nanotubes driven by the strong multiple hydrogen bonding interactions between the cyclic peptides.
Qiao Song +4 more
semanticscholar +1 more source
Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides
Pharmaceutics, 2019 Many proteins can be used to treat brain diseases; however, the presence of the blood−brain barrier (BBB) creates an obstacle to delivering them into the brain.
Kavisha R. Ulapane +2 more
doaj +1 more source
Binding Interactions of Peptide Aptamers
Molecules, 2020 Peptide aptamers are short amino acid chains that are capable of binding specifically to ligands in the same way as their much larger counterparts, antibodies. Ligands of therapeutic interest that can be targeted are other peptide chains or loops located
Roger R. C. New +2 more
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Stimuli-responsive membrane activity of cyclic-peptide–polymer conjugates
Chemical Science, 2019 Cyclic peptide nanotubes were coupled to poly(oxazoline)s using a cleavable connection. Upon stimuli responsive detachment of the polymer an on-demand membrane activity could be achieved.
Matthias Hartlieb +5 more
semanticscholar +1 more source