Split Cyclin-Dependent Kinase 4/6–Retinoblastoma 1 Axis in Pancreatic Cancer [PDF]
Frontiers in Cell and Developmental Biology, 2020 Drugs targeting the cyclin-dependent kinase 4/6 (CDK4/6)–retinoblastoma 1 (RB1) axis have shown efficacy against multiple solid cancers, but their therapeutic potential in pancreatic cancer remains poorly defined.
Xing Huang, Gang Zhang
doaj +3 more sources
Mitotic Regulation of SIRT2 by Cyclin-dependent Kinase 1-dependent Phosphorylation* [PDF]
Journal of Biological Chemistry, 2007 Sirtuins are evolutionarily conserved NAD+-dependent deacetylases and ADP-ribosyltransferases involved in the regulation of cell division, apoptosis, DNA damage repair, genomic silencing, and longevity.
Brian J. North, E. Verdin
semanticscholar +3 more sources
microRNA-769 is Downregulated in Colorectal Cancer and Inhibits Cancer Progression by Directly Targeting Cyclin-Dependent Kinase 1 [Retraction]. [PDF]
Onco Targets Ther, 2021 Lei Wang +3 more
europepmc +3 more sources
Regulation of Osteoblast to Osteocyte Differentiation by Cyclin‐Dependent Kinase‐1 [PDF]
Advanced Biology, 2023 AbstractOsteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance.
Tomoyuki Tanaka +11 more
openalex +3 more sources
Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis. [PDF]
Exp Ther Med, 2019 Gao X +7 more
europepmc +3 more sources
NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation [PDF]
Molecular and Cellular Biology, 2015 The tRNA methytransferase NSun2 promotes cell proliferation, but the molecular mechanism has not been elucidated. Here, we report that NSun2 regulates cyclin-dependent kinase 1 (CDK1) expression in a cell cycle-dependent manner. Knockdown of NSun2 decreased the CDK1 protein level, while overexpression of NSun2 elevated it without altering CDK1 mRNA ...
Junyue Xing +10 more
semanticscholar +3 more sources
Cells, 2023 The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
doaj +1 more source
MicroRNA-337-3p impedes breast cancer progression by targeting cyclin-dependent kinase 1. [PDF]
Oncol Lett, 2022 MicroRNAs (miRNAs/miRs) function as key regulators in breast cancer (BC). The present study aimed to verify the function and molecular regulation of miR-337-3p in BC cells. Bioinformatics analysis was performed to screen key genes and miRNAs associated with BC.
Kong S +5 more
europepmc +4 more sources
Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1
Molecular & Cellular Oncology, 2021 Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids.
Pierre Raia, Jun Yu, Andreas Boland
doaj +1 more source