Results 31 to 40 of about 483,027 (406)

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis [PDF]

, 2015
Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics.
Addya, Sankar, Arnold, Andrew, Cardiff, Robert D, Casimiro, Mathew C, Crosariol, Marco, Dampier, William, Di Sante, Gabriele, Ertel, Adam, FORTINA, PAOLO, Knudsen, Erik S, Li, Zhiping, Lisanti, Michael P, Loro, Emanuele, Papanikolaou, Alexandros, Pestell, Richard G., Saria, Elizabeth A, Tozeren, Aydin, Wang, Chenguang, Yu, Zuoren   +18 more
core   +1 more source

Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy

Open Biology, 2022
Measuring the dynamics with which the regulatory complexes assemble and disassemble is a crucial barrier to our understanding of how the cell cycle is controlled that until now has been difficult to address.
Martina Barbiero, Luca Cirillo, Sapthaswaran Veerapathiran, Catherine Coates, Camilla Ruffilli, Jonathon Pines   +5 more
doaj   +1 more source

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]

, 2010
Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Ainscough, Berezney, Brown, Cardoso, Chevalier, Cook, Coverley, Coverley, den Hollander, Dijkwel, Djeliova, Fujita, Furstenthal, Geng, Geng, Harper, Hozak, Krude, Lowe, Mailand, Mitsui, Moore, Parisi, Radichev, Sherr, Stoeber, Su, Takeda, Tatsumi, Wilmes, Wohlschlegel   +30 more
core   +3 more sources

An In Silico Approach for Potential Natural Compounds as Inhibitors of Protein CDK1/Cks2

Chemistry Proceedings, 2021
CDKs are pivotal mediators essential for the cellular cycle progression. CDKs have relatively constant levels, and their activity is regulated by cyclins, proteins whose concentrations fluctuate during each cell cycle.
Abu Saim Mohammad Saikat
doaj   +1 more source

Cyclin-Dependent Kinase

Definitions, 2020
Cyclin-dependent eukaryotic, phosphoregulated protein kinases that associate with cyclins to control cell cycle progression.
Researcher Código, Orcid A.1, Situación, Artero Formación, Licenciatura, Grado, Doctorado   +6 more
semanticscholar   +1 more source

LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer

Nature Communications, 2020
Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer.
Qianfeng Shi, Yudong Li, Shunying Li, L. Jin, Hongna Lai, Yanqin Wu, Zijie Cai, Mengdi Zhu, Qian Li, Ying Li, Jingru Wang, Yujie Liu, Zongyang Wu, E. Song, Qiang Liu   +14 more
semanticscholar   +1 more source

Cyclin E, a redundant cyclin in breast cancer [PDF]

Proceedings of the National Academy of Sciences, 1996
Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G 1 /S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower ...
Juan Zalvide, Khandan Keyomarsi, James A. DeCaprio, Julie Gray-Bablin, M. Pat Fox, Chris J. Knickerbocker   +5 more
openaire   +3 more sources

Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13

Frontiers in Cell and Developmental Biology, 2019
Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene.
Monika Nováková, Marek Hampl, Marek Hampl, Dávid Vrábel, Jan Procházka, Jan Procházka, Silvia Petrezselyová, Silvia Petrezselyová, Michaela Procházková, Michaela Procházková, Radislav Sedláček, Radislav Sedláček, Michaela Kavková, Tomáš Zikmund, Jozef Kaiser, Hsien-Chia Juan, Ming-Ji Fann, Marcela Buchtová, Marcela Buchtová, Jiří Kohoutek   +19 more
doaj   +1 more source

Cell Cycle Regulation in the Plant Response to Stress

Frontiers in Plant Science, 2020
As sessile organisms, plants face a variety of environmental challenges. Their reproduction and survival depend on their ability to adapt to these stressors, which include water, heat stress, high salinity, and pathogen infection.
Feifei Qi, Fuxin Zhang
doaj   +1 more source

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]

Cell, 1999
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y, Whoriskey, W, Park, M Y, Bronson, R T, Medema, R H, Li, T, Weinberg, R A, Sicinski, P   +7 more
openaire   +5 more sources