Results 41 to 50 of about 230,940 (319)
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation [PDF]
, 2018 p27$^{Kip1}$ (p27) is an intrinsically disordered protein (IDP) that folds upon binding to cyclin-dependent kinase (Cdk)$/$cyclin complexes (e.g., Cdk2$/$cyclin A), inhibiting their catalytic activity and causing cell cycle arrest. However, cell division progresses when stably Cdk2$/$cyclin A-bound p27 is phosphorylated on one or two structurally ...
arxiv +1 more source
Effect of cyclins and Cdks on the cyclin B1 promoter activation [PDF]
IUBMB Life, 1997 AbstractTo study the effect of several cyclins on cyclin B1 promoter activation, we co‐transfected cyclin A, cyclin E and cyclin D1 expressing plasmids with a cyclin B1 promoter construction driving a luciferase repotnter gene into NIH 3T3 cells. All three cyclins produced activation of the reporter gene, however, co‐transfection of cyclin A with a ...
P. Jansen-Duerr +3 more
openaire +3 more sources
Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations [PDF]
Journal of Medicinal Chemistry 49, 5141-5153 (2006), 2008 The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to ...
arxiv +1 more source
, 2006 D type cyclins belong to a family of related proteins that bind to and activate several protein kinases named cyclin-dependent kinases (CDKs), which are involved in regulation of the cell division cycle.
openaire +2 more sources
Cell Reports, 2021 Summary: HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting this potent restriction factor to the endosomes and lysosomes for degradation. However, the precise mechanism remains unclear.
Qingqing Chai +13 more
doaj
A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets [PDF]
arXiv, 2023 The regulatory mechanisms driving progression of the yeast cell cycle appears to be comprised of an interacting network of transcription factors (TFs), cyclin-dependent kinases (CDK) and ubiquitin ligases. From a systems perspective the controlling regulatory network must produce robust periodic behavior during proliferative phases, but have the ...
arxiv
Using a hydrogen-bond index to predict the gene-silencing efficiency of siRNA based on the local structure of mRNA [PDF]
Biochem Biophys Res Comms, vol.320 (2) 622 (2004), 2017 The gene silencing effect of short interfering RNA (siRNA) is known to vary strongly with the targeted position of the mRNA. A number of hypotheses have been suggested to explain this phenomenon. We would like to test if this positional effect is mainly due to the secondary structure of the mRNA at the target site.
arxiv +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Investigation of the impact of PTMs on the protein backbone conformation [PDF]
Amino Acids, Springer Verlag, 2019, 51 (7), pp.1065-1079, 2019 Post-Translational Modifications (PTMs) are known to play a critical role in the regulation of the protein functions. Their impact on protein structures, and their link to disorder regions have already been spotted on the past decade. Nonetheless, the high diversity of PTMs types, and the multiple schemes of protein modifications (multiple PTMs, of ...
arxiv +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source