Results 1 to 10 of about 242,314 (247)

Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction [PDF]

The EMBO Journal, 2000
The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which also contains a nuclear export signal.
Kong, Monica, Barnes, Elizabeth A, Ollendorff, Vincent, Donoghue, Daniel J.   +3 more
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Cyclin E, a redundant cyclin in breast cancer [PDF]

Proceedings of the National Academy of Sciences, 1996
Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G 1 /S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower ...
J, Gray-Bablin, J, Zalvide, M P, Fox, C J, Knickerbocker, J A, DeCaprio, K, Keyomarsi   +5 more
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Cyclin C: The Story of a Non-Cycling Cyclin [PDF]

Biology, 2019
The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels.
Jan Ježek, Daniel G. J. Smethurst, David C. Stieg, Z. A. C. Kiss, Sara E. Hanley, Vidyaramanan Ganesan, Kai-Ti Chang, Katrina F. Cooper, Randy Strich   +8 more
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Cyclin Y, a novel membrane‐associated cyclin, interacts with PFTK1 [PDF]

FEBS Letters, 2009
MINT‐7147695, MINT‐7147713: pftk1 (uniprotkb:O94921) and CCNY (uniprotkb:Q8ND76) colocalize (MI:0403) by fluorescence microscopy (MI:0416)
Jiang, Mei, Gao, Yankun, Yang, Tao, Zhu, Xueliang, Chen, Jiangye   +4 more
openaire   +2 more sources

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis [PDF]

Trends in Cell Biology, 2013
Cell cycle transitions are driven by the periodic oscillations of cyclins, which bind and activate cyclin-dependent kinases (CDKs) to phosphorylate target substrates. Cyclin F uses a substrate recruitment strategy similar to that of the other cyclins, but its associated catalytic activity is substantially different.
D'Angiolella, V, Esencay, M, Pagano, M, Pagano, M   +3 more
openaire   +5 more sources

Characterization and Expression of Mammalian Cyclin B3, a Prepachytene Meiotic Cyclin [PDF]

Journal of Biological Chemistry, 2002
We report the identification and expression pattern of a full-length human cDNA and a partial mouse cDNA encoding cyclin B3. Cyclin B3 (CCNB3) is conserved from Caenorhabditis elegans to Homo sapiens and has an undefined meiotic function in female, but not male Drosophila melanogaster. We show that H. sapiens cyclin B3 interacts with cdk2, is localized
Thomas B, Nguyen, Katia, Manova, Paola, Capodieci, Catherine, Lindon, Steve, Bottega, Xiang-Yuan, Wang, Jale, Refik-Rogers, Jonathon, Pines, Debra J, Wolgemuth, Andrew, Koff   +9 more
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Why Cyclin Y? A highly conserved cyclin with essential functions [PDF]

Fly, 2010
Cyclin Y is one of the most highly conserved members of the cyclin superfamily of proteins, which are famous for their crucial roles in regulating the cell cycle and transcription. Despite this high degree of conservation, very little was known about Cyclin Y function prior to a handful of studies published in this past year. Cyclins typically function
Dongmei Liu, Stephen Guest, Russell L. Finley   +2 more
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Cyclin A triggers Mitosis either via Greatwall or Cyclin B [PDF]

The EMBO Journal, 2018
AbstractTwo mitotic Cyclins, A and B, exist in higher eukaryotes, but their specialised functions in mitosis are poorly understood. Using degron tags we analyse how acute depletion of these proteins affects mitosis. Loss of Cyclin A in G2-phase prevents the initial activation of Cdk1.
Hégarat, Nadia, Crncec, Adrijana, Peredoa Rodri-guez, Maria F. Suarez, Iturra, Fabio Echegaray, Gu, Yan, Lang, Paul F., Barr, Alexis R., Bakal, Chris, Kanemaki, Masato T., Lamond, Angus I., Novak, Bela, Ly, Tony, Hochegger, Helfrid   +12 more
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Arabidopsis D-Type Cyclin CYCD4;1 Is a Novel Cyclin Partner of B2-Type Cyclin-Dependent Kinase [PDF]

Plant Physiology, 2003
Abstract B-type cyclin-dependent kinases (CDKs) are unique to plants and are assumed to be involved in the control of the G2-to-M phase progression and mitotic events. However, little is known about their cyclin partners. In Arabidopsis, we isolated cDNA encoding the D-type cyclin CYCD4;1 by a yeast (Saccharomyces cerevisiae) two-hybrid ...
Atsushi, Kono, Chikage, Umeda-Hara, Jeongkyung, Lee, Masaki, Ito, Hirofumi, Uchimiya, Masaaki, Umeda   +5 more
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Cyclin B and Cyclin A Confer Different Substrate Recognition Properties on CDK2 [PDF]

Cell Cycle, 2007
The transitions of the cell cycle are regulated by the cyclin dependent protein kinases (CDKs). The cyclins activate their respective CDKs and confer substrate recognition properties. We report the structure of phospho-CDK2/cyclin B and show that cyclin B confers M phase-like properties on CDK2, the kinase that is usually associated with S phase ...
Brown, N. R., Lowe, E. D., Petri, E., Skamnaki, V., Antrobus, R., Johnson, L. N.   +5 more
openaire   +3 more sources