Results 1 to 10 of about 2,773,749 (175)
BMC Cancer, 2020 Background A. oxyphylla extract is known to possess a wide range of pharmacological activites. However, the molecular mechanism of A. oxyphylla and its bioactive compound nootkatone in colorectal cancer is unknown.
Eunsu Yoo +6 more
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The double dealing of cyclin D1 [PDF]
Cell Cycle, Taylor & Francis, 2010, pp.1-16, 2020 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
arxiv +1 more source
The kinetics of G2 and M transitions regulated by B cyclins. [PDF]
PLoS ONE, 2013 B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an ...
Yehong Huang +2 more
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Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma
Annals of Agricultural and Environmental Medicine, 2015 [b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the ...
Anna Cyniak-Magierska +5 more
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The 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesis of cyclin B during a mitotic block in human cells. [PDF]
PLoS ONE, 2013 Antimitotic agents are frequently used to treat solid tumors and hematologic malignancies. However, one major limitation of antimitotic approaches is mitotic slippage, which is driven by slow degradation of cyclin B during a mitotic block.
Dominik Schnerch +4 more
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PTBP1 promotes IRES-mediated translation of cyclin B1in cancer
Acta Biochimica et Biophysica Sinica, 2022 Cyclin B1 is an essential cyclin-dependent protein that involves in the G2/M transition. Multiple studies report that cyclin B1 is upregulated in cancers and promotes cancer progression.
Fan Xinyi +5 more
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Folia Histochemica et Cytobiologica, 2012 Cyclins play a fundamental role in the cell cycle. Recent studies have focused on their role in the development of various malignancies. The objective of this study was to evaluate and compare the expression of cyclins A and E in common nevi, dysplastic ...
Ana Alekseenko +6 more
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Cyclin C: The Story of a Non-Cycling Cyclin
Biology, 2019 The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression ...
Jan Ježek +8 more
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siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model. [PDF]
PLoS ONE, 2010 Cyclin E is aberrantly expressed in many types of cancer including breast cancer. High levels of the full length as well as the low molecular weight isoforms of cyclin E are associated with poor prognosis of breast cancer patients.
Yulong Liang +5 more
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Cells, 2019 The deubiquitinase DUB3 is frequently overexpressed in non-small cell lung cancer (NSCLC) and contributes to its malignant phenotype. However, the underlying molecular mechanism of DUB3 in NSCLC is largely unknown.
Bin Hu +12 more
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