Results 11 to 20 of about 242,314 (247)

Overexpression of Cyclin A and Cyclin B1Proteins in Astrocytomas

Archives of Pathology & Laboratory Medicine, 2000
AbstractBackground.—Cyclins are proteins that are expressed during the progression of a normal cell through the cell cycle. In a number of cancers, overexpression of cyclin A and cyclin B1 proteins has been reported, and in some instances the levels of expression correlated well with the grades of malignancy.
K, Allan, R C, Jordan, L C, Ang, M, Taylor, B, Young   +4 more
openaire   +2 more sources

Cycline-A et Cancer [PDF]

médecine/sciences, 1993
La cycline A, associee a la proteine kinase p34 cdc2 , est impliquee dans la transition G2/M du cycle. Elle s'associe aussi a la proteine kinase p33 cdk2 au cours de la phase S du cycle. La cycline A participe a la formation de complexes multimeriques comprenant le facteur de transcription E2F, la proteine kinase p33 cdk2 et la proteine p107 ...
E. Lamas, F. Zindy, J. Sobczack, P. Paterlini, J. Wang, X. Chenivesse, B. Henglein, C. Bréchot   +7 more
openaire   +1 more source

The crystal structure of cyclin A [PDF]

Structure, 1995
Eukaryotic cell cycle progression is regulated by cyclin dependent protein kinases (CDKs) whose activity is regulated by association with cyclins and by reversible phosphorylation. Cyclins also determine the subcellular location and substrate specificity of CDKs.
Brown NR, Noble MEM, Endicott JA, Garman EF, Wakatsuki S, Mitchell E, Rasmussen B, Hunt T, Johnson LN   +8 more
openaire   +3 more sources

Cyclin-dependent kinases: a family portrait [PDF]

Nature Cell Biology, 2009
To the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits. Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of ...
Marcos, Malumbres, Edward, Harlow, Tim, Hunt, Tony, Hunter, Jill M, Lahti, Gerard, Manning, David O, Morgan, Li-Huei, Tsai, Debra J, Wolgemuth   +8 more
openaire   +2 more sources

Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6 [PDF]

Structure, 1999
Cyclin-dependent kinases (CDKs) have a central role in cell-cycle control and are activated by complex formation with positive regulatory proteins called cyclins and by phosphorylation. The overexpression and mutation of cyclins and CDKs has been associated with tumorigenesis and oncogenesis.
Schulze-Gahmen, Ursula, Jung, Jae U, Kim, Sung-Hou   +2 more
openaire   +2 more sources

Phosphorylation of cyclin O, a novel cyclin family protein containing a cyclin-like domain, is involved in the activation of cyclin-dependent kinase 2

Oncology Letters, 2014
Cell cycles, ordered series of events modulating cell growth and division, are tightly regulated by complexes containing cyclin-dependent kinases (CDKs) and cyclins. Cyclin O is a novel cyclin family protein which interacts with CDK2. However, the molecular effects of cyclin O on the activity of CDK2 have not been fully evaluated.
KIM, DO HYUNG, PARK, JONG-HWA, LEE, BORA, JANG, KYOUNG OK, CHUNG, IN SIK, HAN, YE SUN   +5 more
openaire   +3 more sources

Differential Regulation of CDP/Cux p110 by Cyclin A/Cdk2 and Cyclin A/Cdk1 [PDF]

Journal of Biological Chemistry, 2005
Previous experiments with peptide fusion proteins suggested that cyclin A/Cdk1 and Cdk2 might exhibit similar yet distinct phosphorylation specificities. Using a physiological substrate, CDP/Cux, our study confirms this notion. Proteolytic processing of CDP/Cux by cathepsin L generates the CDP/Cux p110 isoform at the beginning of S phase.
Marianne, Santaguida, Alain, Nepveu
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Cyclin B3 Is a Mitotic Cyclin that Promotes the Metaphase-Anaphase Transition [PDF]

Current Biology, 2015
The timing mechanism for mitotic progression is still poorly understood. The spindle assembly checkpoint (SAC), whose reversal upon chromosome alignment is thought to time anaphase [1-3], is functional during the rapid mitotic cycles of the Drosophila embryo; but its genetic inactivation had no consequence on the timing of the early mitoses.
Yuan, Kai, O’Farrell, Patrick H
openaire   +4 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source