Results 11 to 20 of about 22,958,501 (389)
Consequence of the tumor‐associated conversion to cyclin D1b [PDF]
EMBO Molecular Medicine, 2015 Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D1 to
Michael A Augello +12 more
doaj +4 more sources
Ciz1 cooperates with cyclin-A–CDK2 to activate mammalian DNA replication in vitro [PDF]
Journal of Cell Science, 2010 Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
N. Copeland +3 more
semanticscholar +5 more sources
Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]
, 2010 The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Duru, Nadire +5 more
core +11 more sources
Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma
Annals of Agricultural and Environmental Medicine, 2015 [b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the ...
Anna Cyniak-Magierska +5 more
doaj +1 more source
siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model. [PDF]
PLoS ONE, 2010 Cyclin E is aberrantly expressed in many types of cancer including breast cancer. High levels of the full length as well as the low molecular weight isoforms of cyclin E are associated with poor prognosis of breast cancer patients.
Yulong Liang +5 more
doaj +1 more source
How the Cyclin Became a Cyclin [PDF]
Cell, 1999 As is readily apparent, proteolysis plays a tremendously important and varied role in cell cycle regulation. While the SCF and APC are key regulators, other proteolytic systems may also contribute to cell cycle control. A well-documented case is the stabilization of p53 in response to DNA damage.
J. Wade Harper +4 more
openaire +3 more sources
Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins [PDF]
, 2002 Cyclin F, a cyclin that can form SCF complexes and bind to cyclin B, oscillates in the cell cycle with a pattern similar to cyclin A and cyclin B. Ectopic expression of cyclin F arrests the cell cycle in G2/M.
Fung, Tsz Kan +4 more
core +1 more source
Folia Histochemica et Cytobiologica, 2012 Cyclins play a fundamental role in the cell cycle. Recent studies have focused on their role in the development of various malignancies. The objective of this study was to evaluate and compare the expression of cyclins A and E in common nevi, dysplastic ...
Ana Alekseenko +6 more
doaj +1 more source
Amygdalin Blocks Bladder Cancer Cell Growth In Vitro by Diminishing Cyclin A and cdk2
PLoS ONE, 2014 Amygdalin, a natural compound, has been used by many cancer patients as an alternative approach to treat their illness. However, whether or not this substance truly exerts an anti-tumor effect has never been settled.
J. Makarević +8 more
semanticscholar +1 more source
Living with or without cyclins and cyclin-dependent kinases [PDF]
Genes & Development, 2004 Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins. Studies performed over more than a decade have supported the view that these holoenzymes are important, if not ...
James M. Roberts, Charles J. Sherr
openaire +2 more sources