Results 11 to 20 of about 345,409 (245)

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis [PDF]

, 2015
Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics.
Addya, Sankar, Arnold, Andrew, Cardiff, Robert D, Casimiro, Mathew C, Crosariol, Marco, Dampier, William, Di Sante, Gabriele, Ertel, Adam, FORTINA, PAOLO, Knudsen, Erik S, Li, Zhiping, Lisanti, Michael P, Loro, Emanuele, Papanikolaou, Alexandros, Pestell, Richard G., Saria, Elizabeth A, Tozeren, Aydin, Wang, Chenguang, Yu, Zuoren   +18 more
core   +1 more source

Cyclin E, a redundant cyclin in breast cancer [PDF]

Proceedings of the National Academy of Sciences, 1996
Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G 1 /S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower ...
Juan Zalvide, Khandan Keyomarsi, James A. DeCaprio, Julie Gray-Bablin, M. Pat Fox, Chris J. Knickerbocker   +5 more
openaire   +3 more sources

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]

Cell, 1999
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y, Whoriskey, W, Park, M Y, Bronson, R T, Medema, R H, Li, T, Weinberg, R A, Sicinski, P   +7 more
openaire   +5 more sources

Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b) [PDF]

, 2009
Cyclin D1b is an alternative transcript of the cyclin D1 gene (CCND1) expressed in human tumors. Its abundance is regulated by a single base pair polymorphism at the exon 4/intron 4 boundary (nucleotide 870).
Benavides, Fernando, Blando, Jorge, Cardenas, Kim, Conti, Claudio, Johnson, David G., Knudsen, Erik S., Pérez, Carlos, Richie, Ellen, Rodriguez Puebla, Marcelo L., Rojas, Paola Andrea, Senderowicz, Adrian M.   +10 more
core   +1 more source

Translational control of cyclins [PDF]

Cell Division, 2011
Regulation of cyclin levels is important for many cell cycle-related processes and can occur at several different steps of gene expression. Translational regulation of cyclins, which occurs by a variety of regulatory mechanisms, permits a prompt response to signal transduction pathways induced by environmental stimuli.
Ming-Chih Lai, Woan-Yuh Tarn
openaire   +4 more sources

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]

, 2018
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar, Casimiro, Mathew C., Deng, Shengqiong, DiSante, Gabriele, Dong, Lin, Ertel, Adam, Gormley, Michael, Ju, Xiaoming, Li, Qinchuan, Pestell, Richard G., Pestell, Timothy G., Qiao, Jing, Tozeren, Ayden, Wang, Guangxue, Wang, Min, Yu, Zuoren, Zhao, Qian   +16 more
core   +2 more sources

The crystal structure of cyclin A [PDF]

Structure, 1995
Eukaryotic cell cycle progression is regulated by cyclin dependent protein kinases (CDKs) whose activity is regulated by association with cyclins and by reversible phosphorylation. Cyclins also determine the subcellular location and substrate specificity of CDKs.
Brown NR, Noble MEM, Endicott JA, Garman EF, Wakatsuki S, Mitchell E, Rasmussen B, Hunt T, Johnson LN   +8 more
openaire   +3 more sources

Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes. [PDF]

, 2017
Nitrogen-containing bisphosphonates (N-BPs) are the most widely used anti-resorptive agents in the treatment of bone-related diseases. N-BPs inhibit bone resorption by specifically targeting osteoclasts, bone-resorbing cells.
Kang, Mo K, Kim, Reuben H, Lee, Rachel S, Park, No-Hee, Shin, Ki-Hyuk, Sohn, Suhjin   +5 more
core   +1 more source

Asynchronous nuclear division cycles in multinucleated cells [PDF]

, 2006
Synchronous mitosis is common in multinucleated cells. We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya gossypii.
Gladfelter, A. S., Hungerbuehler, A. K., Philippsen, P.   +2 more
core   +2 more sources

Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2 [PDF]

Biochemical and Biophysical Research Communications, 2009
The distinct expression patterns of the two A-type cyclins during spermatogenesis and the absolute requirement for cyclin A1 in this biological process in vivo suggest that they may confer distinct biochemical properties to their CDK partners. We therefore compared human cyclin A1- and cyclin A2-containing CDK complexes in vitro by determining kinetic ...
Vaidehi Jobanputra, Karen M. Lele, Ayesha Joshi, Debra J. Wolgemuth   +3 more
openaire   +3 more sources