Results 221 to 230 of about 222,589 (257)

Factors controlling cyclin B expression

Plant Molecular Biology, 2000
Cyclins control the transition between the phases of the eukaryotic cell cycle as regulatory subunits of the cyclin-dependent kinases (CDKs). Phase-specific activation of the CDK is in part regulated by phase-specific expression of their cyclin component. In most eukaryotic cells including higher plant, B-type cyclin genes are expressed specifically at
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Increase of cyclin B by overexpression of cystatin α

Cell Biochemistry and Function, 1995
AbstractDegradation of cyclin B was effectively suppressed when cells were treated with ALLN (N‐acetylleucylleucylnorleucinal) which inhibits proteasome, calpain and cysteine proteinase cathepsins. In order to examine which protease degrades cyclin B, the effect of a cathepsin inhibitor, cystatin α, was investigated.
T, Hiwasa, J, Ma, Y, Ike, N, Katunuma, S, Sakiyama   +4 more
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Homology Model of the CDK1/cyclin B Complex

Journal of Biomolecular Structure and Dynamics, 2005
We describe a refined homology model of a CDK1/cyclin B complex that was previously used for the structure-based optimization of the Paullone class of inhibitors. The preliminary model was formed from the homologous regions of the deposited CDK2/cyclin A crystal structure. Further refinement of the CDK1/cyclin B complex was accomplished using molecular
Connor F, McGrath, Nagarajan, Pattabiraman, Glen E, Kellogg, Thomas, Lemcke, Conrad, Kunick, Edward A, Sausville, Daniel W, Zaharevitz, Rick, Gussio   +7 more
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Cyclin D1 expression in B-cell lymphomas

Experimental Hematology, 2010
Cyclin D1, an important component of cell cycle machinery and a protein with known oncogenic potential, is downregulated in normal mature B lymphocytes. Its expression detected in a number of malignancies, including B-cell lymphomas, may be important for oncogenesis.In our work, we determined the level of cyclin D1 expression in various B-cell ...
Aleena, Gladkikh, Daria, Potashnikova, Elena, Korneva, Olga, Khudoleeva, Ivan, Vorobjev   +4 more
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Cyclin D1 Inhibits Mitochondrial Activity in B Cells

Cancer Research, 2011
Abstract Cyclin D1 is a cell cycle regulatory protein that acts at the G1-S transition, following its binding to and activation by the cyclin-dependent kinases 4 or 6. Cyclin D1 is absent from the entire B-cell lineage but is present in a large percentage of 2 types of malignant B-cell hemopathy—mantle cell lymphoma and multiple ...
G, Tchakarska, M, Roussel, X, Troussard, Sola, Brigitte   +3 more
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caenorhabditis elegans cyclin a- and b-type genes: A cyclin a multigene family, an ancestral cyclin b3 and differential germline expression

Journal of Cell Science, 1995
ABSTRACT We have cloned cDNAs for Caenorhabditis elegans cyclins A1, B and B3. While cyclins A1 and B are most closely related to either A- or B-type cyclins of other species, cyclin B3 is less related to these cyclins. However, this cyclin is most similar to the recently identified chicken cyclin B3.
Kreutzer, M., Richards, J., De Silva-Udawatta, M., Temenak, J., Knoblich, J., Lehner, C., Bennett, K.   +6 more
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A Cdc2-sensitive interaction of the UbL domain of XDRP1S with cyclin B mediates the degradation of cyclin B in Xenopus egg extracts

Biochemical and Biophysical Research Communications, 2006
The yeast UbL-UBA protein Dsk2 is thought to act as a shuttle protein that delivers polyubiquitinated proteins to the proteasome. Previously, we identified Xenopus Dsk2-related protein, XDRP1, as a cyclin A-interacting protein. Using Xenopus egg extracts, we further characterized its two isoforms, XDRP1L and XDRP1S, with respect to cyclin binding and ...
Kanae, Tanaka, Minoru, Funakoshi, Hideki, Kobayashi   +2 more
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Plant cyclins: a unified nomenclature for plant A-, B- and D-type cyclins based on sequence organization

Plant Molecular Biology, 1996
The comparative analysis of a large number of plant cyclins of the A/B family has recently revealed that plants possess two distinct B-type groups and three distinct A-type groups of cyclins. Despite earlier uncertainties, this large-scale comparative analysis has allowed an unequivocal definition of plant cyclins into either A or B classes. We present
Renaudin, J.P., Doonan, J.H., Freeman, D., Hashimoto, J., Hirt, Heribert, Inzé, Dirk, Jacobs, T., Kouchi, H., Rouzé, Pierre, Sauter, M., Savouré, A., Sorell, D.A., Sundaresan, V., Murray, J.A.H.   +13 more
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[Cyclins A and B: redundancy and specificity].

Pathologie-biologie, 1994
Mitotic cyclins constitute a regulatory subunit of the histone H1 kinase complex. On the basis of primary structure differences, they are divided into two classes, A and B. Both classes are necessary for mitosis to occur. Cyclins A and B differ in the timing of their cellular expression and in their affinity with the various members of the cdk (cyclin ...
D, Wolowiec, M, Ffrench
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Sequence of a cDNA encoding a mouse cyclin B protein

Gene, 1991
We report here the nucleotide sequence of a cDNA encoding a mouse (Mus musculus) cyclin B protein. The deduced protein shows 84%, 66% and 49% similarity with human cyclin, Xenopus cyclin B1 and B2, respectively.
G D, Paterno, K M, Downs
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