Results 11 to 20 of about 96,425 (243)
Molecular Cancer, 2007 Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the development and progression of cancer. Deregulated cyclin D1 degradation appears to be
Alao John P
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The cyclin D1b splice variant: an old oncogene learns new tricks
Cell Division, 2006 The function of cyclin D1 as a positive regulator of the cell cycle and proto-oncogene has been well established. Cyclin D1 elicits its pro-proliferative function early in G1 phase, through its ability to activate cyclin dependent kinase (CDK) 4 or 6 ...
Knudsen Karen E
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Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. [PDF]
PLoS Pathogens, 2011 EBNA3C, one of the Epstein-Barr virus (EBV)-encoded latent antigens, is essential for primary B-cell transformation. Cyclin D1, a key regulator of G1 to S phase progression, is tightly associated and aberrantly expressed in numerous human cancers ...
Abhik Saha +7 more
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BMC Complementary and Alternative Medicine, 2017 Background Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail.
Su Bin Park +6 more
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Cell Division, 2008 Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl J Alan, Pontano Laura L
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Molecular Cancer, 2006 Background Cyclin D1 is an important regulator of G1-S phase cell cycle transition and has been shown to be important for breast cancer development.
Charles Coombes R +4 more
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Cyclin D1 Stability Is Partly Controlled by O-GlcNAcylation
Frontiers in Endocrinology, 2019 Cyclin D1 is the regulatory partner of the cyclin-dependent kinases (CDKs) CDK4 or CDK6. Once associated and activated, the cyclin D1/CDK complexes drive the cell cycle entry and G1 phase progression in response to extracellular signals.
Louis Masclef +6 more
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Indian Journal of Pathology and Microbiology, 2020 Background: Cyclin D1, a member of the cyclin protein family, is instrumental in the cell cycle due to its influence on the progression from G1 to the S phase. Its overexpression causes reduced doubling time and is also associated with clonogenic growth.
Hulya Tosun Yildirim +6 more
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Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer
Current Issues in Molecular Biology, 2022 TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage.
Se-Il Go +7 more
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Cyclin D1 expression in prostate carcinoma
Brazilian Journal of Medical and Biological Research, 2014 The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma.
R.A. Pereira +7 more
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