Results 11 to 20 of about 7,393 (99)
Regulation of Cyclin D1 by Calpain Protease [PDF]
Journal of Biological Chemistry, 1997 Cyclin D1, a critical positive regulator of G1 progression, has been implicated in the pathogenesis of certain cancers. Regulation of cyclin D1 occurs at the transcriptional and posttranscriptional level. Here we present evidence that cyclin D1 levels are regulated at the posttranscriptional level by the Ca2+-activated protease calpain.
Su Jae Lee +9 more
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Cycling to Cancer with Cyclin D1 [PDF]
Cancer Biology & Therapy, 2002 Genetic aberrations in the regulatory circuits that govern transit through the G(1) phase of the cell cycle occur frequently in human cancer and overexpression of the G(1) phase cyclin, cyclin D1, is one of the most commonly observed alterations. Cyclin D1 accumulates and activates its cognate CDK (CDK4/6) in response to mitogenic growth factors in ...
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Cyclin D1 goes metabolic [PDF]
Cell Cycle, 2012 Recent findings have revolutionized thinking in terms of how D-type cyclins control diverse cellular processes including development, cellular proliferation and carcinogenesis. The D-cyclin consists of three members with overlapping functions, cyclin D1, cyclin D2 and cyclin D3.1 Biochemically, D-type cyclins function in late G1 phase as catalysts for ...
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The American Journal of Pathology, 2013 Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis has been well characterized, new functions have been identified, including the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of ...
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Cyclin D1 is a NF-κB corepressor
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 NF-κB regulates the expression of Cyclin D1 (CD1), while RAC3 is an NF-κB coactivator that enhances its transcriptional activity. In this work, we investigated the regulatory role of CD1 on NF-κB activity. We found that CD1 inhibits NF-κB transcriptional activity through a corepressor function that can be reverted by over-expressing RAC3.
Monica Alejandra Costas +9 more
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Cyclin d1 expression in odontogenic cysts [PDF]
Turkish Journal of Pathology, 2013 In the present study expression of cyclin D1 in the epithelial lining of odontogenic keratocyst, radicular cyst, dentigerous cyst and glandular odontogenic cyst was investigated to compare proliferative activity in these lesions.Immunohistochemical staining of cyclin D1 on formalin-fixed, paraffin-embedded tissue sections of odontogenic keratocysts (n ...
Nasim Taghavi +3 more
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New twist in the regulation of cyclin D1
BioMolecular Concepts, 2010 AbstractAmong the cell cycle-related mammalian cyclins, cyclin D1 is more closely connected with cell proliferation in response to extracellular signals than the cell cycle clock itself. Because both its mRNA and protein are labile, the intracellular abundance of cyclin D1 is thought to be largely regulated at the level of transcription.
Jun-ya Kato, Noriko Yoneda-Kato
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Aberrant Expression of Cyclin D1 in Cancer [PDF]
Signal Transduction Insights, 2015 Cyclin D1 binds and activates cyclin-dependent kinases 4/6 (Cdk4/6) to phosphorylate the retinoblastoma (RB) family proteins, relieving E2F/DPs from the negative restraint of RB proteins and histone deacetylases (HDACs). The cyclin D-Cdk4/6 complexes activate cyclin E/Cdk2 through titration of the Cdk inhibitors p21Cip1/p27Kip1.
Kazushi Inoue, Elizabeth A. Fry
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Cyclin D1 Functions in Cell Migration [PDF]
Cell Cycle, 2006 Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer.
George C. Prendergast +3 more
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Cyclin D1, Id1 and EMT in breast cancer [PDF]
BMC Cancer, 2011 Abstract Background Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown that silencing cyclin D1 increases the migratory capacity of MDA-MB-231 breast cancer ...
Andrew H. Sims +7 more
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