The double dealing of cyclin D1 [PDF]
Cell Cycle, 2019 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
Guergana Tchakarska, B. Sola
semanticscholar +8 more sources
Cyclin D1 expression in prostate carcinoma [PDF]
Brazilian Journal of Medical and Biological Research, 2014 The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma.
R.A. Pereira +7 more
doaj +4 more sources
Cyclin D1 and Chemotherapy Response
Indonesian Journal of Cancer, 2021 Cyclin D1 is a protein that plays a role in the transition from the G1 to S phase of the cell cycle. Cyclin D1 expression has been found to increase in various malignancies and, in many studies, was associated with tumor growth, stage, lymph node ...
Rahmat Cahyanur, C. Irawan
semanticscholar +4 more sources
Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma [PDF]
Acta Pharmaceutica Sinica BCyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of cancers. Here, we demonstrated that cyclin D1 is SUMOylated, and we identified Itch as a specific E3 ligase recognizing SUMOylated cyclin D1 and mediating
Ke Lu +10 more
doaj +2 more sources
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. [PDF]
PLoS Pathogens, 2011 EBNA3C, one of the Epstein-Barr virus (EBV)-encoded latent antigens, is essential for primary B-cell transformation. Cyclin D1, a key regulator of G1 to S phase progression, is tightly associated and aberrantly expressed in numerous human cancers ...
Abhik Saha +7 more
doaj +5 more sources
Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis [PDF]
eLifeIn healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.
Nelson García-Vázquez +12 more
doaj +2 more sources
Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes. [PDF]
J Biol Chem, 2023 Cell proliferation requires metabolic reprogramming to accommodate biosynthesis of new cell components, and similar alterations occur in cancer cells. However, the mechanisms linking the cell cycle machinery to metabolism are not well defined. Cyclin D1,
Wu H +9 more
europepmc +3 more sources
Cyclin d1 induces chromosomal instability. [PDF]
Oncotarget, 2012 We developed mouse model systems to investigate the potential for cyclin D1 to induce CIN in vivo. In a mammary gland specific Tet-inducible model the acute expression profile regulated by cyclin D1 after 7 days was enriched in genes that rank highly ...
Casimiro, Mathew C, Pestell, Richard
core +6 more sources
A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription [PDF]
OncogenesisThe essential G1-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type cyclins are rate-limiting regulators of G1-S progression in mammalian cells via their ability to bind and ...
Xuanmao Jiao +22 more
doaj +2 more sources
Evaluation of Cyclin D1 protein and its association with the clinicopathological characteristics and prognosis of lung cancer: A retrospective study from Southern Kerala, India [PDF]
Lung IndiaBackground Cyclin D1 is a protein that can enhance the proliferation of cancer cells and has been detected in various malignancies, including lung cancer. However, routine examinations for Cyclin D1 in lung cancer cases have not been conducted in Kerala.
Neeraja Panakkal +3 more
doaj +2 more sources