Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation [PDF]
Genes & Development, 2000 GSK-3β-dependent phosphorylation of cyclin D1 at Thr-286 promotes the nuclear-to-cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle, but how phosphorylation regulates redistribution has not been resolved. For example, phosphorylation of nuclear cyclin D1 could increase its rate of nuclear export relative to nuclear import ...
Mark Hannink +3 more
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Down-Regulation of Cyclin D1 Expression by Prostaglandin A2 Is Mediated by Enhanced Cyclin D1 mRNA Turnover [PDF]
Molecular and Cellular Biology, 2000 Prostaglandin A(2) (PGA(2)), an experimental chemotherapeutic agent, causes growth arrest associated with decreased cyclin D1 expression in several cancer cell lines. Here, using human non-small-cell lung carcinoma H1299 cells, we investigated the mechanisms whereby PGA(2) down-regulates cyclin D1 expression.
Myriam Gorospe +6 more
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Cyclin D1 Induces Chromosomal Instability
Oncotarget, 2012 We developed mouse model systems to investigate the potential for cyclin D1 to induce CIN in vivo. In a mammary gland specific Tet-inducible model the acute expression profile regulated by cyclin D1 after 7 days was enriched in genes that rank highly with CIN. We also used a mammary gland targeted model (MMTV) to continuously express cyclin D1.
Casimiro, Mathew C, Pestell, Richard
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Cytoplasmic cyclin D1 regulates glioblastoma dissemination [PDF]
The Journal of Pathology, 2019 AbstractGlioblastoma (GBM) is a highly invasive brain neoplasia with an elevated recurrence rate after surgical resection. The cyclin D1 (Ccnd1)/Cdk4–retinoblastoma 1 (RB1) axis is frequently altered in GBM, leading to overproliferation by RB1 deletion or by Ccnd1‐Cdk4 overactivation.
Tània Cemeli +12 more
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Kinase independent oncogenic cyclin D1
Aging, 2015 Strong evidence implicates cyclin D1 overexpression as a driving force in breast cancer and many other types of human tumors. Cyclin D1 overexpression is found in up to 50% of human breast cancers, and the pattern of cyclin D1 overexpression in tissues along the spectrum from normal epithelium to invasive breast cancer suggests its involvement in the ...
Casimiro, Mathew C +2 more
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Cyclin D1 expression in acute leukemia
Hematology, 2006 Disorders of the cell cycle regulatory machinery play a key role in the pathogenesis of cancer. Over expression of cyclin D1 protein has been reported in several solid tumors and certain lymphoid malignancies, but little is known about the involvement of cyclin D1 in acute leukemia.In this study, we analyzed the expression of cyclin D1 at protein level
Mohamed Mabed +4 more
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Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. [PDF]
, 1994 Dalia Resnitzky +3 more
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Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. [PDF]
, 1994 Sharon Bodrug +5 more
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Cyclin D1 expression in penile cancer
OncotargetThe main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017.
Duarte, Wesliany Everton +11 more
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Immunohistochemical Analysis of Cyclin D1 Protein in Hematopoietic Neoplasms with Special Reference to Mantle Cell Lymphoma [PDF]
, 1994 Shigeo Nakamura +13 more
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