Results 21 to 30 of about 319,561 (345)
Cyclin D1 and human neoplasia [PDF]
Molecular Pathology, 1998 Neoplasia is characterised by abnormal regulation of the cell cycle. Cyclin D1 is a protein derived from the PRAD1, CCND1 or bcl-1 gene on chromosome 11q13, which is involved in both normal regulation of the cell cycle and neoplasia. In the G1 (resting) phase of the cell cycle, cyclin D1 together with its cyclin dependent kinase (cdk) partner, is ...
R. Donnellan, Runjan Chetty
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Cyclin D1: A Prognostic Marker in Multiple Myeloma and its Association with CRP and β2-Microglobulin Level [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Cyclin D1 is a protein encoded by the CCND1 (BCL-1) gene on chromosome 11q13 and it is an important regulator of G1 to S phase progression. Over expression of cyclin D1 protein releases cells from their normal controls when they need to
Amrita Singh +7 more
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Cyclin D1 in parathyroid disease [PDF]
Frontiers in Bioscience, 2000 Primary hyperparathyroidism (HPT), most commonly due to parathyroid adenoma, is a disorder characterized by excessive secretion of PTH. So far, abnormalities in two genes, cyclin D1 and MEN1, have been implicated in the development of parathyroid adenomas.
Sanjay M. Mallya
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METTL16 promotes cell proliferation by up‐regulating cyclin D1 expression in gastric cancer
Journal of Cellular and Molecular Medicine, 2021 N6‐methyladenosine (m6A) is a well‐known modification of RNA. However, as a key m6A methyltransferase, METTL16 has not been thoroughly studied in gastric cancer (GC).
Xiao-Kun Wang +9 more
semanticscholar +1 more source
Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression [PDF]
Cancer Science, 2007 Cyclin D1 binds to the Cdk4 and Cdk6 to form a pRB kinase. Upon phosphorylation, pRB loses its repressive activity for the E2F transcription factor, which then activates transcription of several genes required for the transition from the G1‐ to S‐phase and for DNA replication.
Etsu Tashiro +2 more
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Cyclin D1 expression in penile cancer. [PDF]
OncotargetThe main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017.
Duarte WE +11 more
europepmc +3 more sources
An update on the implications of cyclin D1 in melanomas [PDF]
Pigment Cell & Melanoma Research, 2020 AbstractCyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation.
Lucia González‐Ruiz +5 more
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Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma [PDF]
International Journal of Medical Arts, 2021 Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors.
Shimaa Abu_Seadah +2 more
doaj +1 more source
Cells, 2020 Cyclin D1, an important regulator of cell cycle, carries out a central role in the pathogenesis of cancer determining uncontrolled cellular proliferation.
F. Montalto, F. De Amicis
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Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinoma
Frontiers in Oncology, 2023 Cyclin D1 functions as a mitogenic sensor that specifically binds to CDK4/6, thereby integrating external mitogenic inputs and cell cycle progression.
Wei Cai +5 more
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