Results 21 to 30 of about 96,425 (243)
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Galectin-3 and cyclin D1 expression in non-small cell lung cancer
Journal of Experimental & Clinical Cancer Research, 2011 Introduction Lung cancer is a major cause of mortality and morbidity worldwide. Galectin-3 is multifunctional protein, which is involved in regulation of cell growth, cell adhesion, cell proliferation, angiogenesis and apoptosis.
Gołecki Marcin +4 more
doaj +1 more source
Cyclin D1 as a Useful Marker for the Differentiation of Ewing’s Sarcoma from Rhabdomyosarcoma
Middle East Journal of Cancer, 2020 Background: The main oncogenic action of CD99 and cyclin D1 biomarkers is referred to any mutation, amplification, and overexpression in cyclin D1 coding gene, altering cell cycle progression as the main mechanism observed in a variety of tumors.
Tina Shooshtarizadeh +2 more
doaj +1 more source
Cyclin D1 regulates osteoarthritis chondrocyte apoptosis via WNT3/β-catenin signalling
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Objective Cyclin D1 was an important molecular involved in the pathological process of osteoarthritis (OA). The purpose of this study was to identify the effect and potential mechanism of Cyclin D1 for the proliferation and apoptosis of OA chondrocytes ...
Yi-Yue Chen +7 more
doaj +1 more source
E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
Signal Transduction and Targeted Therapy, 2023 Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.
Meng Fang +15 more
doaj +1 more source
Diagnostic Pathology, 2013 Background To evaluate the expression levels of Cyclin D1 in breast papillomas and papillary carcinomas, and to analyze the types of cells that co-express Cyclin D1 with Cytokeratin 5/6 (CK 5/6) or with Cytokeratin 8/18(CK 8/18). Methods Fifty-nine cases
Wang Yu +3 more
doaj +1 more source
Expression Level of Cyclin-D1 between Endometriomas and Ovarian Carcinomes
Mutiara Medika, 2021 Endometrioma on the ovaries is a benign gynecological disorder that is often found in women of reproductive age. The approach was made to the malignant transformation through the study of cyclin-D1 expression.
Alfun Dhiya An +1 more
doaj +1 more source
Cyclin D1 expression of different histological grades in oral squamous cell carcinoma patients from northern India [PDF]
Archive of Oncology, 2018 Cyclin D1 expression was positive in 35 cases of oral cancer with a Cyclin D1 positivity of 22.16±22.18. The percent-age of positive cases as well as Cyclin D1 positivity showed an increase as the grade of differentiation advanced.
Ahmad Gatoo Manzoor, Mahmood Dar Ayaz
doaj
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy
Cell Division, 2007 Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) protein and ...
Lin Douglas I +2 more
doaj +1 more source