Results 31 to 40 of about 319,561 (345)

LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer

Nature Communications, 2020
Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer.
Qianfeng Shi, Yudong Li, Shunying Li, L. Jin, Hongna Lai, Yanqin Wu, Zijie Cai, Mengdi Zhu, Qian Li, Ying Li, Jingru Wang, Yujie Liu, Zongyang Wu, E. Song, Qiang Liu   +14 more
semanticscholar   +1 more source

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.

Proceedings of the National Academy of Sciences of the United States of America, 1999
beta-Catenin plays a dual role in the cell: one in linking the cytoplasmic side of cadherin-mediated cell-cell contacts to the actin cytoskeleton and an additional role in signaling that involves transactivation in complex with transcription factors of ...
M. Shtutman, J. Zhurinsky, I. Simcha, C. Albanese, M. D’Amico, R. Pestell, A. Ben-Ze’ev   +6 more
semanticscholar   +1 more source

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]

Cell, 1999
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y, Whoriskey, W, Park, M Y, Bronson, R T, Medema, R H, Li, T, Weinberg, R A, Sicinski, P   +7 more
openaire   +5 more sources

Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells

BMC Complementary and Alternative Medicine, 2017
Background Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail.
Su Bin Park, Gwang Hun Park, Hun Min Song, Ho-Jun Son, Yurry Um, Hyun-Seok Kim, Jin Boo Jeong   +6 more
doaj   +1 more source

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.

Genes & Development, 1998
The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during G1 phase with the cell-cycle engine that regulates DNA replication and mitosis. Induction of D-type cyclins and their assembly into holoenzyme complexes depend
J. Diehl, M. Cheng, M. Roussel, C. Sherr
semanticscholar   +1 more source

Hsc70 Regulates Accumulation of Cyclin D1 and Cyclin D1-Dependent Protein Kinase [PDF]

Molecular and Cellular Biology, 2003
The cyclin D-dependent kinase is a critical mediator of mitogen-dependent G1 phase progression in mammalian cells. Given the high incidence of cyclin D1 overexpression in human neoplasias, the nature and complexity of cyclin D complexes in vivo have been subjects of intense interest.
Andrew Emili, Ronald A. Rimerman, Hua Xiao, Wensheng Yang, J. Alan Diehl   +4 more
openaire   +3 more sources

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]

, 2018
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar, Casimiro, Mathew C., Deng, Shengqiong, DiSante, Gabriele, Dong, Lin, Ertel, Adam, Gormley, Michael, Ju, Xiaoming, Li, Qinchuan, Pestell, Richard G., Pestell, Timothy G., Qiao, Jing, Tozeren, Ayden, Wang, Guangxue, Wang, Min, Yu, Zuoren, Zhao, Qian   +16 more
core   +2 more sources

Cyclin D1 integrates G9a-mediated histone methylation. [PDF]

, 2019
Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency.
Casimiro, Mathew C., Chepelev, Iouri, Dampier, William, Di Sante, Gabriele, Ertel, Adam, Jeltsch, Albert, Jiao, Xuanmao, Ju, Xiaoming, Katiyar, Sanjay, Klopfenstein, D. V., Li, Zhiping, Pestell, Richard G., Tozeren, Aydin, Wang, Min   +13 more
core   +2 more sources

Histone deacetylase inhibitor, Trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells

Molecular Cancer, 2006
Background Cyclin D1 is an important regulator of G1-S phase cell cycle transition and has been shown to be important for breast cancer development.
Charles Coombes R, Lam Eric, Stavropoulou Alexandra V, Alao John P, Vigushin David M   +4 more
doaj   +1 more source

Galectin-3 and cyclin D1 expression in non-small cell lung cancer

Journal of Experimental & Clinical Cancer Research, 2011
Introduction Lung cancer is a major cause of mortality and morbidity worldwide. Galectin-3 is multifunctional protein, which is involved in regulation of cell growth, cell adhesion, cell proliferation, angiogenesis and apoptosis.
Gołecki Marcin, Kowal Aneta, Piesiak Paweł, Kosacka Monika, Jankowska Renata   +4 more
doaj   +1 more source