Results 31 to 40 of about 90,181 (143)
The Breast, 2006 Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyclin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues.
Pankaj G, Roy, Alastair M, Thompson
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Cyclin D1 regulates osteoarthritis chondrocyte apoptosis via WNT3/β-catenin signalling
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Objective Cyclin D1 was an important molecular involved in the pathological process of osteoarthritis (OA). The purpose of this study was to identify the effect and potential mechanism of Cyclin D1 for the proliferation and apoptosis of OA chondrocytes ...
Yi-Yue Chen +7 more
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E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
Signal Transduction and Targeted Therapy, 2023 Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.
Meng Fang +15 more
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Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma
Acta Pharmaceutica Sinica BCyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of cancers. Here, we demonstrated that cyclin D1 is SUMOylated, and we identified Itch as a specific E3 ligase recognizing SUMOylated cyclin D1 and mediating
Ke Lu +10 more
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Diagnostic Pathology, 2013 Background To evaluate the expression levels of Cyclin D1 in breast papillomas and papillary carcinomas, and to analyze the types of cells that co-express Cyclin D1 with Cytokeratin 5/6 (CK 5/6) or with Cytokeratin 8/18(CK 8/18). Methods Fifty-nine cases
Wang Yu +3 more
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Expression Level of Cyclin-D1 between Endometriomas and Ovarian Carcinomes
Mutiara Medika, 2021 Endometrioma on the ovaries is a benign gynecological disorder that is often found in women of reproductive age. The approach was made to the malignant transformation through the study of cyclin-D1 expression.
Alfun Dhiya An +1 more
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Cyclin D1 expression of different histological grades in oral squamous cell carcinoma patients from northern India [PDF]
Archive of Oncology, 2018 Cyclin D1 expression was positive in 35 cases of oral cancer with a Cyclin D1 positivity of 22.16±22.18. The percent-age of positive cases as well as Cyclin D1 positivity showed an increase as the grade of differentiation advanced.
Ahmad Gatoo Manzoor, Mahmood Dar Ayaz
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SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy
Cell Division, 2007 Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) protein and ...
Lin Douglas I +2 more
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Cyclin d1 expression in odontogenic cysts [PDF]
Turkish Journal of Pathology, 2013 In the present study expression of cyclin D1 in the epithelial lining of odontogenic keratocyst, radicular cyst, dentigerous cyst and glandular odontogenic cyst was investigated to compare proliferative activity in these lesions.Immunohistochemical staining of cyclin D1 on formalin-fixed, paraffin-embedded tissue sections of odontogenic keratocysts (n ...
Nasim, Taghavi +3 more
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Pharmaceuticals, 2012 The histone deacetylase (HDAC) inhibitors, butyrate and trichostatin A (TSA), are epigenetic histone modifiers and proliferation inhibitors by downregulating cyclin D1, a positive cell cycle regulator, and upregulating p21Cip1 and INK family of proteins,
Kasturi Ranganna +3 more
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