Results 41 to 50 of about 319,561 (345)

The extent of cyclin D1 expression in endometrial pathologies and relevance of cyclin D1 with the clinicopathological features of endometrioid endometrial carcinoma

Indian Journal of Pathology and Microbiology, 2020
Background: Cyclin D1, a member of the cyclin protein family, is instrumental in the cell cycle due to its influence on the progression from G1 to the S phase. Its overexpression causes reduced doubling time and is also associated with clonogenic growth.
Hulya Tosun Yildirim, Dondu Nergiz, Canan Sadullahoglu, Zelal Akgunduz, Senay Yildirim, Selen Dogan, Cem Sezer   +6 more
doaj   +1 more source

Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer

Current Issues in Molecular Biology, 2022
TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage.
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha   +7 more
doaj   +1 more source

Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner [PDF]

, 2011
Neural stem and progenitor cells undergo an important transition from proliferation to differentiation in the G1 phase of the cell cycle. The mechanisms coordinating this transition are incompletely understood.
A. I. Lukaszewicz, Altman, Bae, Bertrand, Bienvenu, Briscoe, Budirahardja, Bylund, Bystron, Calegari, Cremisi, D. J. Anderson, Dasen, Dehay, Dehay, Donovan, Fior, Glover, Gui, Hinds, Humbert, Huttner, Jhas, Kageyama, Kerkhoff, Koyano-Nakagawa, Kuida, Lange, Lobjois, Lukaszewicz, Ma, Massagu  , Megason, Mizutani, O'Leary, Ohnuma, Perez, Rao, Rao, Roztocil, Sherr, Tanabe, Tsuchida, Ulloa, White, Zhao, Zhou   +46 more
core   +3 more sources

Transcriptional role of cyclin D1 in development revealed by a “genetic-proteomic” screen [PDF]

, 2010
Author manuscript: 2010 September 22.Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed in human cancers[superscript 1, 2]. The full repertoire of cyclin D1 functions in normal development and oncogenesis is unclear at
A Flora, A Marson, Agnieszka Zagozdzon, Alexander Marson, AP Jadhav, AP Jadhav, C McMahon, C Ratineau, C Ronchini, CJ Sherr, Clifford A. Meyer, Constance L. Cepko, Duncan T. Odom, EA Musgrove, Frédéric Bienvenu, G Das, Garrett M. Frampton, GM Seigel, J Adnane, J Hatakeyama, J Lindsay, Joshua E. Elias, Junko Odajima, K Inoue, Karolina Mizeracka, KJ McManus, M Fu, M Fu, M Malumbres, Marie Jecrois, Megan F. Cole, O Coqueret, O Yaron, P Heine, P Sicinski, Piotr Sicinski, Q Yu, Richard A. Young, RM Zwijsen, S Blackshaw, S Saxonov, SC Yeung, Siwanon Jirawatnotai, Steven P. Gygi, TO Alexson, V Fantl, X. Shirley Liu, Yan Geng   +47 more
core   +1 more source

Regulation of Cyclin D1 by Calpain Protease [PDF]

Journal of Biological Chemistry, 1997
Cyclin D1, a critical positive regulator of G1 progression, has been implicated in the pathogenesis of certain cancers. Regulation of cyclin D1 occurs at the transcriptional and posttranscriptional level. Here we present evidence that cyclin D1 levels are regulated at the posttranscriptional level by the Ca2+-activated protease calpain.
Su Jae Lee, Phuongmai Nguyen, Emiko Takano, Joung Soon Jang, Masatoshi Maki, Jane B. Trepel, Yung Hyun Choi, Jeen Lee, Pierre A. Henkart, Ming-Lei Wu   +9 more
openaire   +3 more sources

Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells [PDF]

, 2012
Undifferentiated nasopharyngeal carcinomas (NPCs) are commonly present with latent EBV infection. However, events regulating EBV infection at early stages of the disease and the role of EBV in disease pathogenesis are largely undefined.
Chen, H, Cheung, ALM, Deng, W, Hau, PM, Lau, VMY, Lo, KW, Lui, VWY, Lung, ML, Middeldorp, JM, Takada, K, To, KF, Tsang, CM, Tsao, SW, Yip, YL, Zeng, M   +14 more
core   +2 more sources

Cyclin D1 and breast cancer

The Breast, 2006
Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyclin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues.
Pankaj G. Roy, Alastair M. Thompson
openaire   +3 more sources

Cyclin D1 Stability Is Partly Controlled by O-GlcNAcylation

Frontiers in Endocrinology, 2019
Cyclin D1 is the regulatory partner of the cyclin-dependent kinases (CDKs) CDK4 or CDK6. Once associated and activated, the cyclin D1/CDK complexes drive the cell cycle entry and G1 phase progression in response to extracellular signals.
Louis Masclef, Vanessa Dehennaut, Marlène Mortuaire, Céline Schulz, Maïté Leturcq, Tony Lefebvre, Anne-Sophie Vercoutter-Edouart   +6 more
doaj   +1 more source

Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth [PDF]

, 2017
The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that drives cell autonomous cell cycle progression and proliferation. Herein we show cyclin D1 abundance is increased >30-fold in the stromal fibroblasts of patients with invasive breast ...
Addya, Ashkar, Banerjee, Ben-Ze’ev, Bissell, Blagosklonny, Bosco, Broering, Bronte, Burbelo, Calvo, Chambon, Cox, Cullen, Cullen, Cullen, Dubois, Engelhardt, Epstein, Ertel, Esumi, Fusenig, Garcia, Grotendorst, Hanahan, Hopkinson, Hortobagyi, Howell, Jain, Jeannin, Jecrois, Jukkola-Vuorinen, Kalluri, Kang, Leung, Levine, Liaw, Lisanti, Lisanti, Lisanti, Lisanti, Mann, Martinez-Outschoorn, Matrisian, McKeehan, Nagaraj, Nakamura, Nevalainen, Orimo, Papanikolaou, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pestell, Pollard, Pollard, Pollard, Pollard, Pollard, Pontén, Prisco, Rimm, Rui, Rushton, Rønnov-Jessen, Sakakura, Samant, Scherer, Sicinski, Soloff, Sotgia, Soucek, Speicher, Speicher, Tanes, Tang, Tarkowski, Uede, Wang, Weinberg, Weinberg, West, Wong, Xiang   +90 more
core   +3 more sources

Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Hepatology, 2018
Dysfunction of degradation machineries causes cancers, including hepatocellular carcinoma (HCC). Overexpression of cyclin D1 in HCC has been reported. We previously reported that autophagy preferentially recruits and degrades the oncogenic microRNA (miR)‐
Shan-Ying Wu, S. Lan, Shang-Rung Wu, Yen-Chi Chiu, Xi-Zhang Lin, I. Su, T. Tsai, C. Yen, T. Lu, F. Liang, Chung-Yi Li, H. Su, C. Su, H-S Liu   +13 more
semanticscholar   +1 more source