Results 41 to 50 of about 90,181 (143)
The American Journal of Pathology, 2013 Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis has been well characterized, new functions have been identified, including the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of ...
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Indian Journal of Medical and Paediatric Oncology, 2013 Background: Cyclin D1 dysregulation is an early and unifying oncogenic event in patients of multiple myeloma (MM). This may be detected up to 30% cases by immunohistochemistry (IHC) and up to 40-50% cases by molecular studies.
Somanath Padhi +2 more
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BMC Complementary and Alternative Medicine, 2018 Background Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied.
Su Bin Park +7 more
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The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines
Molecular Cancer, 2006 Background The cyclin D1 proto-oncogene is an important regulator of G1 to S-phase transition and an important cofactor for several transcription factors in numerous cell types. Studies on neonatal cardiomyocytes and postmitotic neurons indicate that the
Coombes R Charles +6 more
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Cyclin D1 Functions in Cell Migration [PDF]
Cell Cycle, 2006 Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer.
Zhiping, Li +3 more
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The Relationships between cyclin D1 Expression and Prognosis of Non-small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2010 Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis.
Jiping ZHU +4 more
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The double dealing of cyclin D1 [PDF]
Cell Cycle, 2019 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
Tchakarska, Guergana, Sola, Brigitte
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Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma
World Journal of Surgical Oncology, 2012 Background Cyclin D1 gene regulates cell cycle and plays an important role in the tumorigenesis of human cancers. The association between cyclin D1, clinicopathologic parameters and prognosis in oral cavity squamous cell carcinoma (OSCC) is inconclusive.
Huang Shiang-Fu +6 more
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Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels
BMC Cell Biology, 2006 Background The expression level of cyclin D1 plays a vital role in the control of proliferation. This protein is reported to be degraded following phosphorylation by glycogen synthase kinase 3 (GSK3) on Thr-286. We recently showed that phosphorylation of
Hitomi Masahiro +6 more
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Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
Neural Development, 2009 Background Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina.
Choi Yoon +3 more
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