Results 51 to 60 of about 319,561 (345)

The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription [PDF]

, 2009
Epithelial tight junctions recruit different types of signalling proteins that regulate cell proliferation and differentiation. Little is known about how such proteins interact functionally and biochemically with each other.
Aijaz, S., Balda, M.S., Leefa Chong San, I.V., Matter, K., Nie, M.   +4 more
core   +2 more sources

CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1- mantle cell lymphoma.

Blood, 2019
Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in overexpression of cyclin D1. However, a small subset of cyclin D1- MCL has been recognized, and approximately one-half of them harbor CCND2 translocations ...
D. Martín-García, A. Navarro, R. Valdés-Mas, G. Clot, J. Gutiérrez-Abril, Miriam Prieto, Inmaculada Ribera‐Cortada, R. Woroniecka, G. Rymkiewicz, S. Bens, L. de Leval, A. Rosenwald, J. Ferry, E. Hsi, K. Fu, J. Delabie, D. Weisenburger, D. de Jong, F. Climent, S. O'Connor, S. Swerdlow, D. Torrents, Sergi Beltran, B. Espinet, B. González-Farré, L. Veloza, D. Costa, E. Matutes, R. Siebert, G. Ott, L. Quintanilla‐Martinez, E. Jaffe, C. López-Otín, I. Salaverria, X. Puente, E. Campo, S. Beá   +36 more
semanticscholar   +1 more source

Cycling to Cancer with Cyclin D1 [PDF]

Cancer Biology & Therapy, 2002
Genetic aberrations in the regulatory circuits that govern transit through the G(1) phase of the cell cycle occur frequently in human cancer and overexpression of the G(1) phase cyclin, cyclin D1, is one of the most commonly observed alterations. Cyclin D1 accumulates and activates its cognate CDK (CDK4/6) in response to mitogenic growth factors in ...
openaire   +2 more sources

Cyclin D1 as a Useful Marker for the Differentiation of Ewing’s Sarcoma from Rhabdomyosarcoma

Middle East Journal of Cancer, 2020
Background: The main oncogenic action of CD99 and cyclin D1 biomarkers is referred to any mutation, amplification, and overexpression in cyclin D1 coding gene, altering cell cycle progression as the main mechanism observed in a variety of tumors.
Tina Shooshtarizadeh, Ladan Fereidooni, Dorna Motevalli   +2 more
doaj   +1 more source

Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression [PDF]

, 2015
Insulin constitutes a major evolutionarily conserved hormonal axis for maintaining glucose homeostasis1-3; dysregulation of this axis causes diabetes2,4. PGC-1α links insulin signaling to the expression of glucose and lipid metabolic genes5-7.
Camporez, Joao Paulo, Chim, Helen, Choi, Yoon Jong, Dominy, John E., Jurczak, Michael, Lee, Yoonjin, Lim, Ji-Hong, Puigserver, Pere, Ruan, Hai-Bin, Shulman, Gerald I., Sicinski, Piotr, Tolliday, Nicola, Vazquez, Francisca, Yang, Xiaoyong   +13 more
core   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

Genes & Development, 1993
A cascade of events is triggered upon the addition of growth factor to quiescent mammalian cells, which ultimately restarts proliferation by inducing the transition from G0/G1 to S-phase. We have studied cyclin D1, a putative G1 cyclin, in normal diploid
ronique Baldin, J. Lukas, Maria Jesfis Marcote, M. Pagano, G. Draetta   +4 more
semanticscholar   +1 more source

DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1. [PDF]

, 2015
Let-7 miRNAs act as tumour suppressors by directly binding to the 3\u27UTRs of downstream gene products. The regulatory role of let-7 in downstream gene expression has gained much interest in the cancer research community, as it controls multiple ...
Du, Ning, Li, Xiang, Liu, Jian, Luo, Gang, Qin, Sida, Ren, Hong, Sun, Xin, Tang, Shou-Ching, Wang, Chenguang, Xu, Chongwen, Xu, Fei, Zhang, Yiwen, Zhou, Jie   +12 more
core   +2 more sources

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models*

Journal of Biological Chemistry, 2016
Deubiquitinases are important components of the protein degradation regulatory network. We report the discovery of ML364, a small molecule inhibitor of the deubiquitinase USP2 and its use to interrogate the biology of USP2 and its putative substrate ...
Mindy I. Davis, R. Pragani, Jennifer T Fox, M. Shen, K. Parmar, Emily F. Gaudiano, Li Liu, C. Tanega, L. McGee, M. Hall, Crystal McKnight, P. Shinn, H. Nelson, D. Chattopadhyay, A. D’Andrea, D. Auld, L. DeLucas, Zhuyin Li, M. Boxer, A. Simeonov   +19 more
semanticscholar   +1 more source

Cyclin D1 goes metabolic [PDF]

Cell Cycle, 2012
Recent findings have revolutionized thinking in terms of how D-type cyclins control diverse cellular processes including development, cellular proliferation and carcinogenesis. The D-cyclin consists of three members with overlapping functions, cyclin D1, cyclin D2 and cyclin D3.1 Biochemically, D-type cyclins function in late G1 phase as catalysts for ...
openaire   +3 more sources