Results 51 to 60 of about 90,181 (143)

The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC

Analytical Cellular Pathology, 2022
Background. Esophageal cancer is one of the most common malignant tumors of the digestive system, with high incidence and mortality. Methods. Immunohistochemical method was used to detect the expression of MACC1, c-Met, and cyclin D1 in ESCC and its ...
Yan Shi, Meng-Yan Li, Hui Wang, Chao Li, Wen-Ying Liu, Yong-Mei Gao, Bo Wang, Jia-Wei Song, Yu-Qing Ma   +8 more
doaj   +1 more source

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation [PDF]

Genes & Development, 2000
GSK-3β-dependent phosphorylation of cyclin D1 at Thr-286 promotes the nuclear-to-cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle, but how phosphorylation regulates redistribution has not been resolved. For example, phosphorylation of nuclear cyclin D1 could increase its rate of nuclear export relative to nuclear import ...
J R, Alt, J L, Cleveland, M, Hannink, J A, Diehl   +3 more
openaire   +2 more sources

Protein expression patterns of cell cycle regulators in operable breast cancer.

PLoS ONE, 2017
Background-aimTo evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, cyclin E1, p21, p27 and p53 in the context of various breast cancer subtypes.MethodsCyclin E1, cyclin D1, p53, p21 and p27 were evaluated with ...
Flora Zagouri, Vassiliki Kotoula, George Kouvatseas, Maria Sotiropoulou, Triantafyllia Koletsa, Theofani Gavressea, Christos Valavanis, Helen Trihia, Mattheos Bobos, Georgios Lazaridis, Angelos Koutras, George Pentheroudakis, Pantelis Skarlos, Dimitrios Bafaloukos, Niki Arnogiannaki, Sofia Chrisafi, Christos Christodoulou, Pavlos Papakostas, Gerasimos Aravantinos, Paris Kosmidis, Charisios Karanikiotis, George Zografos, Christos Papadimitriou, George Fountzilas   +23 more
doaj   +1 more source

Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. [PDF]

PLoS ONE, 2015
Huachansu, a traditional Chinese medicine prepared from the dried toad skin, has been used in clinical studies for various cancers in China. Resibufogenin is a component of huachansu and classified as bufadienolides.
Masami Ichikawa, Yoshihiro Sowa, Yosuke Iizumi, Yuichi Aono, Toshiyuki Sakai   +4 more
doaj   +1 more source

Cyclin D1 Determines Mitochondrial Function InVivo [PDF]

Molecular and Cellular Biology, 2006
The cyclin D1 gene encodes a regulatory subunit of the holoenzyme that phosphorylates and inactivates the pRb tumor suppressor to promote nuclear DNA synthesis. cyclin D1 is overexpressed in human breast cancers and is sufficient for the development of murine mammary tumors.
Toshiyuki, Sakamaki, Mathew C, Casimiro, Xiaoming, Ju, Andrew A, Quong, Sanjay, Katiyar, Manran, Liu, Xuanmao, Jiao, Anping, Li, Xueping, Zhang, Yinan, Lu, Chenguang, Wang, Stephen, Byers, Robert, Nicholson, Todd, Link, Melvin, Shemluck, Jianguo, Yang, Stanley T, Fricke, Phyllis M, Novikoff, Alexandros, Papanikolaou, Andrew, Arnold, Christopher, Albanese, Richard, Pestell   +21 more
openaire   +2 more sources

Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells

BMC Complementary and Alternative Medicine, 2019
Background Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the anti-cancer property of S. thea
Ha Na Kim, Gwang Hun Park, Su Bin Park, Jeong Dong Kim, Hyun Ji Eo, Ho-Jun Son, Jeong Ho Song, Jin Boo Jeong   +7 more
doaj   +1 more source

A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription

Oncogenesis
The essential G1-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type cyclins are rate-limiting regulators of G1-S progression in mammalian cells via their ability to bind and ...
Xuanmao Jiao, Gabriele Di Sante, Mathew C. Casimiro, Agnes Tantos, Anthony W. Ashton, Zhiping Li, Yen Quach, Dharmendra Bhargava, Agnese Di Rocco, Claudia Pupo, Marco Crosariol, Tamas Lazar, Peter Tompa, Chenguang Wang, Zuoren Yu, Zhao Zhang, Kawthar Aldaaysi, Ratna Vadlamudi, Monica Mann, Emmanuel Skordalakes, Andrew Kossenkov, Yanming Du, Richard G. Pestell   +22 more
doaj   +1 more source

The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index

Haematologica, 2012
Background Mantle cell lymphoma is a clinically heterogeneous disease characterized by overexpression of cyclin D1 protein. Blastoid morphology, high proliferation, and secondary genetic aberrations are markers of aggressive behavior.
Julia Slotta-Huspenina, Ina Koch, Laurence de Leval, Gisela Keller, Margit Klier, Karin Bink, Marcus Kremer, Mark Raffeld, Falko Fend, Leticia Quintanilla-Martinez   +9 more
doaj   +1 more source

Cycling to Cancer with Cyclin D1 [PDF]

Cancer Biology & Therapy, 2002
Genetic aberrations in the regulatory circuits that govern transit through the G(1) phase of the cell cycle occur frequently in human cancer and overexpression of the G(1) phase cyclin, cyclin D1, is one of the most commonly observed alterations. Cyclin D1 accumulates and activates its cognate CDK (CDK4/6) in response to mitogenic growth factors in ...
openaire   +2 more sources

Cyclin D₁ and Rb protein expression and their correlation with prognosis in patients with colon cancer

World Journal of Surgical Oncology, 2006
Background Cyclin D1 plays a major role as a potential contributor to the multistep process of oncogenesis; nevertheless its prognostic significance in colon cancer has already been examined in a few studies and needs to be further delineated. The aim of
Giaginis Costas, Vagianos Costas, Glinavou Andromahi, Vamvakas Panayiotis, Theocharis Stamos, Kouraklis Gregory, Sioka Crysoula   +6 more
doaj   +1 more source