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Translational control of cyclins [PDF]
Regulation of cyclin levels is important for many cell cycle-related processes and can occur at several different steps of gene expression. Translational regulation of cyclins, which occurs by a variety of regulatory mechanisms, permits a prompt response
W. Tarn, M. Lai
semanticscholar +6 more sources
Identification of Arabidopsis Meiotic Cyclins Reveals Functional Diversification among Plant Cyclin Genes [PDF]
Meiosis is a modified cell division in which a single S-phase is followed by two rounds of chromosome segregation resulting in the production of haploid gametes.
P. Bulánková+3 more
semanticscholar +2 more sources
Living with or without cyclins and cyclin-dependent kinases. [PDF]
Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins.
C. Sherr, James M. Roberts
semanticscholar +3 more sources
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. [PDF]
Conditional overexpression of human cyclins B1, D1, and E was accomplished by using a synthetic cDNA expression system based on the Escherichia coli tetracycline repressor. After induction of these cyclins in asynchronous Rat-1 fibroblasts, a decrease in
D. Resnitzky+3 more
semanticscholar +2 more sources
Cell cyclins: triggering elements of cancer or not?
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the
M. Stamatakos+6 more
semanticscholar +3 more sources
Cyclins and cyclin-dependent kinases: a biochemical view. [PDF]
J. Pines
semanticscholar +4 more sources
The Less Known Cyclins—Uncovered
Cyclins belong to a group of proteins that are cyclically produced and destructed in a cell. Cyclins are a family of proteins that are a key component of the cell cycle regulating system, which level of expression depends on the phase of the cycle ...
Agnieszka Żuryń+4 more
doaj +1 more source
Dysregulation of G1 cyclins (cyclins D1 A and E) expression contributes to the loss of standard cell cycle control during tumorigenesis. This study aims to evaluate the inhibitory effect of G1 cyclins in nude mice.
Gholamreza Mesbah+6 more
doaj +1 more source
Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins. [PDF]
Gammaherpesvirus cyclins have expanded biochemical features relative to mammalian cyclins, and promote infection and pathogenesis including acute lung infection, viral persistence, and reactivation from latency.
Katherine S Lee+5 more
doaj +1 more source
It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
Peter K. Jackson, Peter K. Jackson
openaire +4 more sources