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Expression Dynamics and Genetic Compensation of Cell Cycle Paralogues in Saccharomyces cerevisiae [PDF]

Cells
Cell cycle progression of the yeast Saccharomyces cerevisiae is largely driven by the expression of cyclins, which in turn bind the cyclin-dependent kinase CDK1 providing specificity.
Gabriele Schreiber, Facundo Rueda, Florian Renner, Asya Fatima Polat, Philipp Lorenz, Edda Klipp   +5 more
doaj   +2 more sources

The Less Known Cyclins—Uncovered

Applied Sciences, 2021
Cyclins belong to a group of proteins that are cyclically produced and destructed in a cell. Cyclins are a family of proteins that are a key component of the cell cycle regulating system, which level of expression depends on the phase of the cycle ...
Agnieszka Żuryń, Aleksandra Opacka, Adrian Krajewski, Wioletta Zielińska, Alina Grzanka   +4 more
doaj   +1 more source

In vivo assessment of simultaneous G1 cyclins silencing by a tumor-specific bidirectional promoter on the mammary tumor in nude mice

Frontiers in Veterinary Science, 2022
Dysregulation of G1 cyclins (cyclins D1 A and E) expression contributes to the loss of standard cell cycle control during tumorigenesis. This study aims to evaluate the inhibitory effect of G1 cyclins in nude mice.
Gholamreza Mesbah, Fatemeh Namazi, Fatemeh T. Shamsabadi, Zahra Maleki, Mehrab Nasirikenari, Majid Shahbazi, Majid Shahbazi   +6 more
doaj   +1 more source

Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins. [PDF]

PLoS Pathogens, 2012
Gammaherpesvirus cyclins have expanded biochemical features relative to mammalian cyclins, and promote infection and pathogenesis including acute lung infection, viral persistence, and reactivation from latency.
Katherine S Lee, Andrea L Suarez, David J Claypool, Taylor K Armstrong, Erin M Buckingham, Linda F van Dyk   +5 more
doaj   +1 more source

Prediction of Cyclin Protein Using Two-Step Feature Selection Technique

IEEE Access, 2020
Cyclins are a family of proteins that regulate the cell cycle by activating cyclin-dependent kinases or a group of enzymes required in the cell cycle. Constructing a model to classify Cyclins is of importance to understand their function. It is urgent to
Jia-Nan Sun, Hua-Yi Yang, Jing Yao, Hui Ding, Shu-Guang Han, Cheng-Yan Wu, Hua Tang   +6 more
doaj   +1 more source

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

Cells, 2022
Pancreatic cancer is a leading cause of cancer mortality and is projected to become the second-most common cause of cancer mortality in the next decade. While gene-wide association studies and next generation sequencing analyses have identified molecular
Cristina Di Giorgio, Antonio Lupia, Silvia Marchianò, Martina Bordoni, Rachele Bellini, Carmen Massa, Ginevra Urbani, Rosalinda Roselli, Federica Moraca, Valentina Sepe, Bruno Catalanotti, Elva Morretta, Maria Chiara Monti, Michele Biagioli, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +16 more
doaj   +1 more source

Emerging Mechanisms of G1/S Cell Cycle Control by Human and Mouse Cytomegaloviruses

mBio, 2021
Cytomegaloviruses (CMVs) are among the largest pathogenic viruses in mammals. To enable replication of their long double-stranded DNA genomes, CMVs induce profound changes in cell cycle regulation.
Boris Bogdanow, Quang Vinh Phan, Lüder Wiebusch   +2 more
doaj   +1 more source

Two-way communication between cell cycle and metabolism in budding yeast: what do we know?

Frontiers in Microbiology, 2023
Coordination of cell cycle and metabolism exists in all cells. The building of a new cell is a process that requires metabolic commitment to the provision of both Gibbs energy and building blocks for proteins, nucleic acids, and membranes.
Yanfei Zhang, Yanfei Zhang, Lucas van der Zee, Matteo Barberis, Matteo Barberis, Matteo Barberis   +5 more
doaj   +1 more source

CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression

Biology, 2023
Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis ...
Mohammed El Dika, Damian Dudka, Malgorzata Kloc, Jacek Z. Kubiak   +3 more
doaj   +1 more source

Analysis of cyclins A, B1, D1 and E in breast cancer in relation to tumour grade and other prognostic factors

BMC Research Notes, 2009
Background The cell cycle is promoted by activation of cyclin dependent kinases (Cdks), which are regulated positively by cyclins and negatively by Cdk inhibitors. Proliferation of carcinoma is associated with altered regulation of the cell cycle. Little
Collan Yrjö, Vahlberg Tero, Palokangas Tuire, Söderström Mirva, Boström Pia, Carpen Olli, Hirsimäki Pirkko   +6 more
doaj   +1 more source