Results 1 to 10 of about 57,502 (167)

Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction [PDF]

The EMBO Journal, 2000
The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which also contains a nuclear export signal.
Kong, Monica, Barnes, Elizabeth A, Ollendorff, Vincent, Donoghue, Daniel J.   +3 more
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Virus-encoded cyclin. [PDF]

Molecular and Cellular Biology, 1994
Herpesvirus saimiri contains an open reading frame called eclf2 with homology to the cellular type D cyclins. We now show that the eclf2 gene product is a novel virus-encoded cyclin (v-cyclin). The protein encoded by the v-cyclin gene of this oncogenic herpesvirus was found to have an apparent molecular size of 29 kDa in transformed cells.
J U, Jung, M, Stäger, R C, Desrosiers
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Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity [PDF]

Journal of Virology, 2012
ABSTRACTAlterations in the functional levels of cyclin-dependent kinase-8 (CDK8) or its partner, cyclin C, have been clearly associated with cancers, including colon cancer, melanoma, and osteosarcoma. Walleye dermal sarcoma virus encodes a retroviral cyclin (RV-cyclin) that localizes to interchromatin granule clusters and binds CDK8.
Joel, Rovnak, Connie D, Brewster, Sandra L, Quackenbush   +2 more
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Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2 [PDF]

Biochemical and Biophysical Research Communications, 2009
The distinct expression patterns of the two A-type cyclins during spermatogenesis and the absolute requirement for cyclin A1 in this biological process in vivo suggest that they may confer distinct biochemical properties to their CDK partners. We therefore compared human cyclin A1- and cyclin A2-containing CDK complexes in vitro by determining kinetic ...
Ayesha R, Joshi, Vaidehi, Jobanputra, Karen M, Lele, Debra J, Wolgemuth   +3 more
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Cyclin E, a redundant cyclin in breast cancer [PDF]

Proceedings of the National Academy of Sciences, 1996
Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G 1 /S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower ...
J, Gray-Bablin, J, Zalvide, M P, Fox, C J, Knickerbocker, J A, DeCaprio, K, Keyomarsi   +5 more
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Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function [PDF]

, 2023
Diana Piol, Laura Tosatto, Emanuela Zuccaro, Eric N. Anderson, Antonella Falconieri, María José Polanco, Caterina Marchioretti, Federica Lia, Joseph White, Elisa Bregolin, Giovanni Minervini, Sara Parodi, Xavier Salvatella, Giorgio Arrigoni, Andrea Ballabio, Albert R. La Spada, Silvio C. E. Tosatto, Fabio Sambataro, Diego L. Medina, Udai Bhan Pandey, Manuela Basso, Maria Pennuto   +21 more
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Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]

Cell, 1999
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y, Whoriskey, W, Park, M Y, Bronson, R T, Medema, R H, Li, T, Weinberg, R A, Sicinski, P   +7 more
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Cycling without Cyclins [PDF]

Cell Cycle, 2004
Complex oscillations in the activation and inactivation of cyclin-dependent kinase complexes propel mammalian cells through the cycle. A recent spate of studies seems to indicate that many, if not most, of these seemingly essential molecules may, in some senses, be dispensable.
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Cyclins and Cyclin Dependent Kinases during Cardiac Development

Molecules and Cells, 1997
The molecular mechanisms that regulate the cardiomyocyte cell cycle and its terminal differentiation remain largely unknown. To determine which cyclins or cyclin dependent kinases (CDKs) are important for cardiomyocyte proliferation, we examined the expression of cyclins and CDKs during normal cardiac development.
Kang, MJ, Kim, JS, Chae, SW, Koh, KN, Koh, GY Koh, Gou Young   +4 more
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Cyclin-dependent kinases [PDF]

Genome Biology, 2014
SummaryCyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.
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