Results 11 to 20 of about 130,501 (296)

Identification of Arabidopsis meiotic cyclins reveals functional diversification among plant cyclin genes.

PLoS Genetics, 2013
Meiosis is a modified cell division in which a single S-phase is followed by two rounds of chromosome segregation resulting in the production of haploid gametes.
Petra Bulankova, Svetlana Akimcheva, Nicole Fellner, Karel Riha   +3 more
doaj   +2 more sources

Sumoylation of cyclin and its therapeutic potential for cancer [PDF]

Animal Cells and Systems
The precision of the cell cycle is essential for organismal development, tissue homeostasis, and the prevention of malignancies. Cyclins and cyclin-dependent kinases (CDKs) play pivotal roles in regulating cell cycle progression.
Hong-Yeoul Ryu, Mark Hochstrasser
doaj   +2 more sources

CRL4AMBRA1 is a master regulator of D-type cyclins

Nature, 2021
Daniele Simoneschi, Gergely Róna, Nan Zhou   +2 more
exaly   +2 more sources

Expression Dynamics and Genetic Compensation of Cell Cycle Paralogues in Saccharomyces cerevisiae [PDF]

Cells
Cell cycle progression of the yeast Saccharomyces cerevisiae is largely driven by the expression of cyclins, which in turn bind the cyclin-dependent kinase CDK1 providing specificity.
Gabriele Schreiber, Facundo Rueda, Florian Renner, Asya Fatima Polat, Philipp Lorenz, Edda Klipp   +5 more
doaj   +2 more sources

Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases

Nature Reviews Molecular Cell Biology, 2016
Marcos Malumbres, Piotr Sicinski
exaly   +2 more sources

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

Cell, 1997
We demonstrate that fizzy-related (fzr), a conserved eukaryotic gene, negatively regulates the levels of cyclins A, B, and B3. These mitotic cyclins that bind and activate cdk1(cdc2) are rapidly degraded during exit from M and during G1. While Drosophila
Christian F Lehner
exaly   +2 more sources

Mouse Development and Cell Proliferation in the Absence of D-Cyclins

Cell, 2004
Maria A Ciemerych, Shoumo Bhattacharya, Piotr Sicinski   +2 more
exaly   +2 more sources

The Less Known Cyclins—Uncovered

Applied Sciences, 2021
Cyclins belong to a group of proteins that are cyclically produced and destructed in a cell. Cyclins are a family of proteins that are a key component of the cell cycle regulating system, which level of expression depends on the phase of the cycle ...
Agnieszka Żuryń, Aleksandra Opacka, Adrian Krajewski, Wioletta Zielińska, Alina Grzanka   +4 more
doaj   +1 more source

In vivo assessment of simultaneous G1 cyclins silencing by a tumor-specific bidirectional promoter on the mammary tumor in nude mice

Frontiers in Veterinary Science, 2022
Dysregulation of G1 cyclins (cyclins D1 A and E) expression contributes to the loss of standard cell cycle control during tumorigenesis. This study aims to evaluate the inhibitory effect of G1 cyclins in nude mice.
Gholamreza Mesbah, Fatemeh Namazi, Fatemeh T. Shamsabadi, Zahra Maleki, Mehrab Nasirikenari, Majid Shahbazi, Majid Shahbazi   +6 more
doaj   +1 more source

CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression

Biology, 2023
Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis ...
Mohammed El Dika, Damian Dudka, Malgorzata Kloc, Jacek Z. Kubiak   +3 more
doaj   +1 more source