Results 31 to 40 of about 130,501 (296)
Frontiers in Oncology, 2020 Increased protein synthesis is a key process in melanoma, which is regulated by the ALDH18A1 gene encoding pyrroline-5-carboxylate synthase (P5CS). P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit ...
Gregory R. Kardos +15 more
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Cyclins regulating oocyte meiotic cell cycle progression†
Biology of Reproduction, 2019 Oocyte meiotic maturation is a vital and final process in oogenesis. Unlike somatic cells, the oocyte needs to undergo two continuous meiotic divisions (meiosis I and meiosis II) to become a haploid gamete.
Jian Li, Wei-Ping Qian, Qing-Yuan Sun
semanticscholar +1 more source
Functions of cyclins and CDKs in mammalian gametogenesis†
Biology of Reproduction, 2019 Cyclins and cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. Most of our understanding of their functions has been obtained from studies in single-cell organisms and mitotically proliferating cultured cells.
Jessica Y Chotiner +2 more
semanticscholar +1 more source
BMC Research Notes, 2009 Background The cell cycle is promoted by activation of cyclin dependent kinases (Cdks), which are regulated positively by cyclins and negatively by Cdk inhibitors. Proliferation of carcinoma is associated with altered regulation of the cell cycle. Little
Collan Yrjö +6 more
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Atypical cyclins: the extended family portrait
Cellular and Molecular Life Sciences, 2019 Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by an oscillating (cyclic) pattern of expression and by the presence ...
Eva Quandt +2 more
semanticscholar +1 more source
Folia Histochemica et Cytobiologica, 2012 Cyclins play a fundamental role in the cell cycle. Recent studies have focused on their role in the development of various malignancies. The objective of this study was to evaluate and compare the expression of cyclins A and E in common nevi, dysplastic ...
Ana Alekseenko +6 more
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Cyclins and CDKs in the regulation of meiosis-specific events
Frontiers in Cell and Developmental Biology, 2022 How eukaryotic cells control their duplication is a fascinating example of how a biological system self-organizes specific activities to temporally order cellular events.
Inés Palacios-Blanco +1 more
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Living with or without cyclins and cyclin-dependent kinases.
Genes & Development, 2004 Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins.
C. Sherr, James M. Roberts
semanticscholar +1 more source
Molecular evolution of cyclin proteins in animals and fungi
BMC Evolutionary Biology, 2011 Background The passage through the cell cycle is controlled by complexes of cyclins, the regulatory units, with cyclin-dependent kinases, the catalytic units.
Afonnikov Dmitry A +4 more
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Divide or Commit – Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis
Frontiers in Cell and Developmental Biology, 2019 The adult dentate gyrus continuously generates new neurons that endow the brain with increased plasticity, helping to cope with changing environmental and cognitive demands.
Anja Urbach, Otto W. Witte
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