Results 31 to 40 of about 141,408 (359)
Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]
Cell, 1999 D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y +7 more
openaire +5 more sources
Frontiers in Plant Science, 2023 IntroductionThe leaf, the main product organ, is an essential factor in determining the Chinese cabbage growth, yield and quality.MethodsTo explore the regulatory mechanism of leaf size development of Chinese cabbage, we investigated the leaf size ...
Lixia Wang +11 more
doaj +1 more source
Atypical cyclins: the extended family portrait
Cellular and Molecular Life Sciences, 2019 Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by an oscillating (cyclic) pattern of expression and by the presence ...
Eva Quandt +2 more
semanticscholar +1 more source
Drug-Free Approach To Study the Unusual Cell Cycle of
mSphere, 2017 Giardia intestinalis is a protozoan parasite that causes giardiasis, a form of severe and infectious diarrhea. Despite the importance of the cell cycle in the control of proliferation and differentiation during a giardia infection, it has been difficult ...
Kathleen Horlock-Roberts +5 more
doaj +1 more source
Kinase-independent function of E-type cyclins in liver cancer
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Amplification of the cyclin E genes and overexpression of cyclin E proteins is very frequent in several human tumor types. In particular, overexpression of E cyclins was implicated in the pathogenesis of liver cancers.
Y. Geng +13 more
semanticscholar +1 more source
Clinical significance and biological roles of cyclins in gastric cancer
OncoTargets and Therapy, 2018 Background and aim Cyclins have been reported to be overexpressed with poor prognosis in several human cancers. However, limited numbers of studies evaluated the expressions and prognostic roles of cyclins in gastric cancer (GC).
Hai-Ping Zhang +3 more
semanticscholar +1 more source
G3: Genes, Genomes, Genetics, 2019 A delicate relationship exists between reef-building corals and their photosynthetic endosymbionts. Unfortunately, this relationship can be disrupted, with corals expelling these algae when temperatures rise even marginally above the average summer ...
Michael L. Cato +5 more
doaj +1 more source
Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors
Cell Cycle, 2015 While targeting experiments carried out on the genes encoding many cell cycle regulators have challenged our views of cell cycle control, they also suggest that redundancy might not be the only explanation for the observed perplexing phenotypes.
N. Bendris, B. Lemmers, J. Blanchard
semanticscholar +1 more source
Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2 [PDF]
Biochemical and Biophysical Research Communications, 2009 The distinct expression patterns of the two A-type cyclins during spermatogenesis and the absolute requirement for cyclin A1 in this biological process in vivo suggest that they may confer distinct biochemical properties to their CDK partners. We therefore compared human cyclin A1- and cyclin A2-containing CDK complexes in vitro by determining kinetic ...
Vaidehi Jobanputra +3 more
openaire +3 more sources
Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle.
PLoS ONE, 2019 In eukaryotes, the cell cycle is driven by the actions of several cyclin dependent kinases (CDKs) and an array of regulatory proteins called cyclins, due to the cyclical expression patterns of the latter. In yeast, the accepted pattern of cyclin waves is
Elisabet Bállega +7 more
doaj +1 more source