Discovery of Novel Cyclic Ethers with Synergistic Antiplasmodial Activity in Combination with Valinomycin [PDF]
Molecules, 2021 With drug resistance threatening our first line antimalarial treatments, novel chemotherapeutics need to be developed. Ionophores have garnered interest as novel antimalarials due to their theorized ability to target unique systems found in the ...
Daniel J. Watson +5 more
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Cyclodepsipeptides and Sesquiterpenes from Marine-Derived Fungus Trichothecium roseum and Their Biological Functions [PDF]
Marine Drugs, 2018 On the basis of the ‘one strain, many compounds’ (OSMAC) strategy, chemical investigation of the marine-derived fungus Trichothecium roseum resulted in the isolation of trichomide cyclodepsipeptides (compounds 1⁻4) from PDB medium, and ...
Yuan-Ming Zhou +4 more
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“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin [PDF]
Marine Drugs, 2013 Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized.
Marta Pelay-Gimeno +2 more
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Computational Pharmacokinetics Report, ADMET Study and Conceptual DFT‐Based Estimation of the Chemical Reactivity Properties of Marine Cyclopeptides [PDF]
ChemistryOpen, 2021 Homophymines A–E and A1–E1 are bioactive natural cyclodepsipeptides with a complex molecular architecture. These molecules could have a potential use as antimicrobial, antiviral, and anticancer substances. We have carried out a computational study of the
Dr. Norma Flores‐Holguín +2 more
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Cytotoxic and Antibacterial Cyclodepsipeptides from an Endophytic Fungus Fusarium avenaceum W8 [PDF]
MoleculesSeven cyclic depsipeptides, including two new cyclic pentadepsipeptides avenamides A (1) and B (2), were isolated from a plant-derived fungus Fusarium avenaceum W8 by using the bioassay-guided fractionation method.
Zimo Wang +5 more
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The Penicillium brasilianum Histone Deacetylase Clr3 Regulates Secondary Metabolite Production and Tolerance to Oxidative Stress [PDF]
Journal of Fungi, 2022 Most of the biosynthetic gene clusters (BGCs) found in microbes are silent under standard laboratory cultivation conditions due to the lack of expression triggering stimuli, representing a considerable drawback in drug discovery.
Daniel Yuri Akiyama +6 more
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Modification and Structure–Activity Relationship Study of Cyclodepsipeptide Trichodestruxin D Derivatives as Potential Antitumor Agents [PDF]
Pharmaceutical FrontsTrichodestruxins A–D are cyclic peptides isolated from the plant endophyte fungus Trichoderma harzianum with inhibitory activities against the proliferation of tumor cells. This study aimed to modify the structure of trichodestruxin D (TD-(R)) to improve
Jihua Zou +5 more
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A new anthelmintic cyclodepsipeptide, PF1022A.
The Journal of Antibiotics, 1992 The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (FERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-meth ylleucyl-D-lactyl-L-N- methylleucyl-D-3 ...
Toru Sasaki +5 more
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The Inhibitory Effects of Cyclodepsipeptides from the Entomopathogenic Fungus Beauveria bassiana on Myofibroblast Differentiation in A549 Alveolar Epithelial Cells [PDF]
Molecules, 2018 Pulmonary fibrosis (PF) is a chronic and fatal lung disease with few treatment options. Although the pathogenesis of PF is not clear, a chronic inflammatory response to continuous damage is considered the cause of pulmonary fibrosis.
Yong Joo Park +6 more
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Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products [PDF]
Molecules, 2013 Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis.
Markus Kaiser, Sara C. Stolze
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