Results 21 to 30 of about 577 (161)

Genome-Guided Discovery of Antimalarial 4-Amino-2,4-Pentadienoate-Containing Cyclolipodepsipeptides. [PDF]

Angew Chem Int Ed Engl
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Candra H, Wang XJ, Go KD, Feng L, Cai M, Ma GL, Widyantoro C, Tan LT, Bozdech Z, Wang Z, Liang ZX.   +10 more
europepmc   +2 more sources

Anti-Infective and Antiviral Activity of Valinomycin and Its Analogues from a Sea Cucumber-Associated Bacterium, Streptomyces sp. SV 21

Marine Drugs, 2021
The manuscript investigated the isolation, characterization and anti-infective potential of valinomycin (3), streptodepsipeptide P11A (2), streptodepsipeptide P11B (1), and one novel valinomycin analogue, streptodepsipeptide SV21 (4), which were all ...
Joko T. Wibowo, Matthias Y. Kellermann, Matthias Köck, Masteria Y. Putra, Tutik Murniasih, Kathrin I. Mohr, Joachim Wink, Dimas F. Praditya, Eike Steinmann, Peter J. Schupp   +9 more
doaj   +1 more source

Synthesis of Aureobasidin B Analogs and Their Antifungal Activity Against Candida albicans [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2022
Aureobasidins (Abs) are a class of cyclodepsipeptides with interesting antifungal properties but they are difficult to synthesize. This study aimed to synthesize analogs of aureobasidin B (AbB) by a combination of solid- and solution-phase synthesis and ...
Rani Maharani, Ace Hidayat, Ace Tatang Hidayat, Desi Harneti, Ika Wiani, Nurlelasari Nurlelasari, Unang Supratman   +6 more
doaj   +1 more source

An Unexpected Formation of a 14‐Membered Cyclodepsipeptide [PDF]

Helvetica Chimica Acta, 2003
AbstractThe treatment of diluted solutions of the hydroxy diamides 6a and 6b in toluene with HCl gas at 100° gave the dimeric, 14‐membered cyclodepsipeptide 10 in up to 72% yield (Scheme 3). The same product was formed from the linear dimer of 6b, the depsipeptide 11, under the same conditions (cf. Scheme 4).
Iliev, Boyan, Linden, Anthony, Heimgartner, Heinz   +2 more
openaire   +2 more sources

Total Synthesis of the Anthelmintic Cyclodepsipeptide, PF1022A [PDF]

Bioscience, Biotechnology, and Biochemistry, 1994
The anthelmintic cyclooctadepsipeptide PF1022A and its antipode were synthesized starting from l-Nα-Boc-leucine (for PF1022A), d-Nα-Boc-leucine (for the antipode), l-lactic acid, and l-phenyllactic acid using Mitsunobu reaction and/or the DCC/HOBt method. The antipode had no anthelmintic efficacy.
Ohyama, Makoto, Iinuma, Katsuharu, Isogai, Akira, Suzuki, Akinori   +3 more
openaire   +1 more source

New Antimicrobial Cyclodepsipeptides from a Freshwater Fungus from the Sierra Madre Oriental in Mexico. [PDF]

ACS Omega
Yeverino IR, Bocanegra Sosa TP, Aguilar-Vega L, García-Contreras R, Magaña-González JL, Figueroa M.   +5 more
europepmc   +2 more sources

Beauveria felina Accelerates Growth When Competing With Other Potential Endophytes. [PDF]

Environ Microbiol Rep
This study compared the growth rate of Beauveria felina alone and in interaction with other endophytic fungi. In the presence of each competitor (Gliomastix polychroma or Rhodotorula mucilaginosa), B. felina grew faster than in the control. In the interaction between Beauveria felina and Gliomastix polychroma, an inhibition zone was formed between ...
Pijanowski W, Chmielewski S, Wysoczański W, Havrysh P, Turnau K, Lembicz M.   +5 more
europepmc   +2 more sources

The first total synthesis of the cyclodepsipeptide pipecolidepsin A [PDF]

Nature Communications, 2013
Pipecolidepsin A is a head-to-side-chain cyclodepsipeptide isolated from the marine sponge Homophymia lamellosa. This compound shows relevant cytotoxic activity in three human tumour cell lines and has unique structural features, with an abundance of non-proteinogenic residues, including several intriguing amino acids. Although the  moieties present in
Pelay-Gimeno, Marta, García-Ramos, Yésica, Martín, María Jesús, Spengler, Jan, Molina-Guijarro, José Manuel, MUNT, SIMON, Francesch, Andres, Cuevas, Carmen, Tulla-Puche, Judit, Albericio, Fernando   +9 more
openaire   +2 more sources

Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research

Molecules, 2014
Faced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential.
Sivatharushan Sivanathan, Jürgen Scherkenbeck   +1 more
doaj   +1 more source

Conformational studies of destruxins, insecticidal cyclodepsipeptides. [PDF]

Agricultural and Biological Chemistry, 1976
The solution conformations of protodestruxin, desmethyldestruxtn B and destruxin B, insecticidal cyclodepsipeptides, in DMSO-d6 have been studied through the use of 100–MHz proton NMR spectroscopy. Proton-deuteron exchange and temperature dependence of the peptide proton chemical shift were used to delineate peptide protons in terms of exposure to ...
NAGANAWA, Hiroshi, TAKITA, Tomohisa, SUZUKI, Akinori, TAMURA, Saburo, LEE, Sannamu, IZUMIYA, Nobuo   +5 more
openaire   +2 more sources