Cytotoxic and Antibacterial Cyclodepsipeptides from an Endophytic Fungus Fusarium avenaceum W8. [PDF]
MoleculesSeven cyclic depsipeptides, including two new cyclic pentadepsipeptides avenamides A (1) and B (2), were isolated from a plant-derived fungus Fusarium avenaceum W8 by using the bioassay-guided fractionation method.
Wang Z +5 more
europepmc +2 more sources
The Penicillium brasilianum Histone Deacetylase Clr3 Regulates Secondary Metabolite Production and Tolerance to Oxidative Stress. [PDF]
J Fungi (Basel), 2022 Most of the biosynthetic gene clusters (BGCs) found in microbes are silent under standard laboratory cultivation conditions due to the lack of expression triggering stimuli, representing a considerable drawback in drug discovery.
Akiyama DY +6 more
europepmc +2 more sources
Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products [PDF]
Molecules, 2013 Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis.
Markus Kaiser, Sara C. Stolze
doaj +3 more sources
Computational Pharmacokinetics Report, ADMET Study and Conceptual DFT-Based Estimation of the Chemical Reactivity Properties of Marine Cyclopeptides. [PDF]
ChemistryOpen, 2021 Homophymines A–E and A1–E1 are bioactive natural cyclodepsipeptides with a complex molecular architecture. These molecules could have a potential use as antimicrobial, antiviral, and anticancer substances. We have carried out a computational study of the
Flores-Holguín N +2 more
europepmc +2 more sources
Polydosetins & pullularins-bioactive tetramic acids & cyclodepsipeptides from the endophytic and nematophagous fungus Polydomus karssenii. [PDF]
Nat Prod BioprospectIn course of investigating the endophytic and nematode-associated fungus Polydomus karssenii for the production of secondary metabolites, seven previously undescribed natural products were isolated from liquid and solid-state fermentations. 1D and 2D NMR
Llanos-López NA +6 more
europepmc +2 more sources
The Inhibitory Effects of Cyclodepsipeptides from the Entomopathogenic Fungus Beauveria bassiana on Myofibroblast Differentiation in A549 Alveolar Epithelial Cells. [PDF]
Molecules, 2018 Pulmonary fibrosis (PF) is a chronic and fatal lung disease with few treatment options. Although the pathogenesis of PF is not clear, a chronic inflammatory response to continuous damage is considered the cause of pulmonary fibrosis.
Park YJ +6 more
europepmc +2 more sources
Hyphomycetes, as Organisms Producing Cyclodepsipeptides
Антибиотики и Химиотерапия, 2020 The review deals with cyclodepsipeptides produced by hyphomycetes. The cyclodepsipeptide compounds are prospective new agents for the treatment of diseases of the infectious and pathophysiologic nature.
M. V. Bibikova +2 more
doaj +1 more source
The endophytic fungus <i>Cosmosporella</i> sp. VM-42 from <i>Vinca minor</i> is a source of bioactive compounds with potent activity against drug-resistant bacteria. [PDF]
Curr Res Microb SciMedicinal plants serve as valuable resources for the isolation of endophytic fungi. Vinca minor is a well-known producer of important vinca alkaloids and emerges as a promising source of endophytic fungi with antibacterial potential and biosynthetic ...
He T +5 more
europepmc +2 more sources
Antibiofilm and cytotoxic metabolites from the entomopathogenic fungus Samsoniella aurantia. [PDF]
Beilstein J Org ChemDuring the course of our studies on the secondary metabolism of rare, hitherto untapped Thai insect-associated fungi, the ethyl acetate (EtOAc) extract derived from solid-state cultivation of Samsoniella aurantia on rice afforded one previously ...
Toshe R +11 more
europepmc +2 more sources
Total Synthesis of Cyclodepsipeptide Xylaroamide A
ChemistryCyclodepsipeptides constitute a structurally diverse class of natural products composed of amino acid and hydroxy acid residues interconnected through both amide and ester bonds.
Rongping Wu +8 more
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