Results 11 to 20 of about 579 (162)

Cyclodepsipeptides and Sesquiterpenes from Marine-Derived Fungus Trichothecium roseum and Their Biological Functions [PDF]

Marine Drugs, 2018
On the basis of the ‘one strain, many compounds’ (OSMAC) strategy, chemical investigation of the marine-derived fungus Trichothecium roseum resulted in the isolation of trichomide cyclodepsipeptides (compounds 1⁻4) from PDB medium, and ...
Yuan-Ming Zhou, Guang-Lin Ju, Lin Xiao, Xiang-Fei Zhang, Feng-Yu Du   +4 more
doaj   +2 more sources

Polydosetins & pullularins—bioactive tetramic acids & cyclodepsipeptides from the endophytic and nematophagous fungus Polydomus karssenii [PDF]

Natural Products and Bioprospecting
In course of investigating the endophytic and nematode-associated fungus Polydomus karssenii for the production of secondary metabolites, seven previously undescribed natural products were isolated from liquid and solid-state fermentations. 1D and 2D NMR
Natalia A. Llanos-López, Jan-Peer Wennrich, Janette Miled, Samad Ashrafi, Wolfgang Maier, Frank Surup, Marc Stadler   +6 more
doaj   +2 more sources

Cytotoxic and Antibacterial Cyclodepsipeptides from an Endophytic Fungus Fusarium avenaceum W8 [PDF]

Molecules
Seven cyclic depsipeptides, including two new cyclic pentadepsipeptides avenamides A (1) and B (2), were isolated from a plant-derived fungus Fusarium avenaceum W8 by using the bioassay-guided fractionation method.
Zimo Wang, Bo Liu, Yanlei Wang, Yicen Xu, Hai Ma, Yi Sun   +5 more
doaj   +2 more sources

The Penicillium brasilianum Histone Deacetylase Clr3 Regulates Secondary Metabolite Production and Tolerance to Oxidative Stress [PDF]

Journal of Fungi, 2022
Most of the biosynthetic gene clusters (BGCs) found in microbes are silent under standard laboratory cultivation conditions due to the lack of expression triggering stimuli, representing a considerable drawback in drug discovery.
Daniel Yuri Akiyama, Marina Campos Rocha, Jonas Henrique Costa, Caroline Brandão Teles, Giuliana da Silva Zuccoli, Iran Malavazi, Taicia Pacheco Fill   +6 more
doaj   +2 more sources

The Inhibitory Effects of Cyclodepsipeptides from the Entomopathogenic Fungus Beauveria bassiana on Myofibroblast Differentiation in A549 Alveolar Epithelial Cells [PDF]

Molecules, 2018
Pulmonary fibrosis (PF) is a chronic and fatal lung disease with few treatment options. Although the pathogenesis of PF is not clear, a chronic inflammatory response to continuous damage is considered the cause of pulmonary fibrosis.
Yong Joo Park, Seoung Rak Lee, Dong Min Kim, Jae Sik Yu, Christine Beemelmanns, Kyu Hyuck Chung, Ki Hyun Kim   +6 more
doaj   +2 more sources

Antibiofilm and cytotoxic metabolites from the entomopathogenic fungus Samsoniella aurantia [PDF]

Beilstein Journal of Organic Chemistry
During the course of our studies on the secondary metabolism of rare, hitherto untapped Thai insect-associated fungi, the ethyl acetate (EtOAc) extract derived from solid-state cultivation of Samsoniella aurantia on rice afforded one previously ...
Rita Toshe, Syeda J. Khalid, Blondelle Matio Kemkuignou, Esteban Charria-Girón, Paul Eckhardt, Birthe Sandargo, Kunlapat Nuchthien, J. Jennifer Luangsa-ard, Till Opatz, Hedda Schrey, Sherif S. Ebada, Marc Stadler   +11 more
doaj   +2 more sources

The endophytic fungus Cosmosporella sp. VM-42 from Vinca minor is a source of bioactive compounds with potent activity against drug-resistant bacteria [PDF]

Current Research in Microbial Sciences
Medicinal plants serve as valuable resources for the isolation of endophytic fungi. Vinca minor is a well-known producer of important vinca alkaloids and emerges as a promising source of endophytic fungi with antibacterial potential and biosynthetic ...
Ting He, Xiao Li, Rosario del Carmen Flores-Vallejo, Ana-Maria Radu, Jan Maarten van Dijl, Kristina Haslinger   +5 more
doaj   +2 more sources

Hyphomycetes, as Organisms Producing Cyclodepsipeptides

Антибиотики и Химиотерапия, 2020
The review deals with cyclodepsipeptides produced by hyphomycetes. The cyclodepsipeptide compounds are prospective new agents for the treatment of diseases of the infectious and pathophysiologic nature.
M. V. Bibikova, T. O. Puzhevskaya, A. V. Katlinsky   +2 more
doaj   +1 more source

Genome-Guided Discovery of Antimalarial 4-Amino-2,4-Pentadienoate-Containing Cyclolipodepsipeptides. [PDF]

Angew Chem Int Ed Engl
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Candra H, Wang XJ, Go KD, Feng L, Cai M, Ma GL, Widyantoro C, Tan LT, Bozdech Z, Wang Z, Liang ZX.   +10 more
europepmc   +2 more sources

Total Synthesis of Cyclodepsipeptide Xylaroamide A

Chemistry
Cyclodepsipeptides constitute a structurally diverse class of natural products composed of amino acid and hydroxy acid residues interconnected through both amide and ester bonds.
Rongping Wu, Dongping Qiu, Yogini S. Jaiswal, Xinrong Xie, Leonard L. Williams, Yu Fan, Hedong Bian, Yifu Guan, Shaoyang Su   +8 more
doaj   +2 more sources