Results 61 to 70 of about 577 (161)

Toward Understanding the Mechanism of Client‐Selective Small Molecule Inhibitors of the Sec61 Translocon

Journal of Molecular Recognition, Volume 38, Issue 1, January 2025.
ABSTRACT The Sec61 translocon mediates the translocation of numerous, newly synthesized precursor proteins into the lumen of the endoplasmic reticulum or their integration into its membrane. Recently, structural biology revealed conformations of idle or substrate‐engaged Sec61, and likewise its interactions with the accessory membrane proteins Sec62 ...
Nidhi Sorout, Volkhard Helms
wiley   +1 more source

Two Novel Hepatocellular Carcinoma Cycle Inhibitory Cyclodepsipeptides from a Hydrothermal Vent Crab-Associated Fungus Aspergillus clavatus C2WU

Marine Drugs, 2013
Two novel cyclodepsipeptides containing an unusual anthranilic acid dimer and a d-phenyllactic acid residues, clavatustides A (1) and B (2), were identified from cultured mycelia and broth of Aspergillus clavatus C2WU isolated from Xenograpsus ...
Wei Jiang, Panpan Ye, Chen-Tung Arthur Chen, Kuiwu Wang, Pengyuan Liu, Shan He, Xiaodan Wu, Lishe Gan, Ying Ye, Bin Wu   +9 more
doaj   +1 more source

Investigating the Anticancer Effect of Streptomyces sp. M12 Extract Against Glioblastoma U87_MG Cell Line

Cellular Microbiology, Volume 2025, Issue 1, 2025.
Glioblastoma, the most aggressive and fatal form of brain tumor, is characterized by rapid growth, extensive invasion of surrounding tissues, and significant angiogenesis. These and other types of cancer remain a leading cause of mortality worldwide, with conventional treatments such as chemotherapy, radiation, and surgery often limited by significant ...
Hasti Rezaee, Ensieh Salehghamari, Atefeh Khamoushi, Hanieh Jalali, Mahsa Asadi Ardalani, Suraiya Saleem   +5 more
wiley   +1 more source

Built-in 5-Aminooxazole as an Internal Activator of the Terminal Carboxylic Acid: An Alternative Access to Macrocyclodepsipeptides

CHIMIA, 2011
A conceptually novel macrolactonization technology is described. A strategically positioned 5-aminooxazole served as an internal traceless activator of the neighboring C-terminal carboxylic acid allowing the occurrence of macrolactonization ...
Jieping Zhu
doaj   +1 more source

Unveiling VCAM‐1’s Multifaceted Role in Secondary Diabetic Complications

Journal of Food Quality, Volume 2025, Issue 1, 2025.
Diabetes mellitus is a chronic metabolic disorder characterized by sustained hyperglycemia, tightly interlinked with a range of severe secondary complications. Diabetic retinopathy, nephropathy, and cardiomyopathy substantially contribute to the overall morbidity and mortality associated with diabetes.
Prabhnain Kaur, Ritu, Kalicharan Sharma, Ramesh K. Goyal, Parakh Basist, Rahmuddin Khan, Abdulsalam Alhalmi, Mohamed Addi   +7 more
wiley   +1 more source

Design of Marine Cyclodepsipeptide Analogues Targeting Candida albicans Efflux Pump CaCdr1p

Drugs and Drug Candidates
Fungal infections are a significant threat to human health and the environment. The emergence of multidrug-resistant strains of fungi and the growing prevalence of azole resistance in invasive fungal infections exacerbate the problem, with efflux pumps ...
Ricardo Ribeiro, Sara Fortes, Lia Costa, Andreia Palmeira, Eugénia Pinto, Emília Sousa, Carla Fernandes   +6 more
doaj   +1 more source

Hochgradig cytotoxische Cryptophycine mit modifiziertem Fragment D zur Konjugation

Angewandte Chemie, Volume 136, Issue 50, December 9, 2024.
Cytotoxische Cryptophycine mit diversen konjugierbaren funktionellen Gruppen in Fragment D sind über einen hocheffizienten und skalierbaren Syntheseweg zugänglich. Diese ABC+D Strategie ermöglichte die Synthese einer breiten Bibliothek von Cryptophycinen und führte zu einer quantitativen Struktur‐Wirkungsbeziehung, welche die Synthese der wirksamsten ...
Cedric Dessin, Thomas Schachtsiek, Jona Voss, Anne‐Catherine Abel, Beate Neumann, Hans‐Georg Stammler, Andrea E. Prota, Norbert Sewald   +7 more
wiley   +1 more source

Highly Cytotoxic Cryptophycin Derivatives with Modification in Unit D for Conjugation

Angewandte Chemie International Edition, Volume 63, Issue 50, December 9, 2024.
Cytotoxic cryptophycins with versatile conjugation handles in unit D are accessible by a highly efficient and scalable synthetic route. This ABC+D strategy enabled the creation of a vast array of cryptophycins leading to a quantitative structure activity relationship, allowing for the synthesis of most potent conjugable cryptophycin derivatives being ...
Cedric Dessin, Thomas Schachtsiek, Jona Voss, Anne‐Catherine Abel, Beate Neumann, Hans‐Georg Stammler, Andrea E. Prota, Norbert Sewald   +7 more
wiley   +1 more source

Characterization of Cyclodepsipeptides from the Mycelium of from Vietnam

Natural Product Communications, 2017
A new cyclodepsipeptide, isarin ( 1 ), was isolated from the insect pathogenic fungus Isaria japonica Yasuda, together with one known compound, beauveriolide I ( 2 ).
Nguyen Ngoc Tuan, Nguyen Thi Ngan, Ping-Chung Kuo, Hsin-Yi Hung, Tran Ngoc Lan, Nguyen Tan Thanh, Dao Thi Thanh Xuan, Tran Dinh Thang, Tian-Shung Wu   +8 more
doaj   +1 more source

Stereoselective Synthesis of α‐Azido Esters and α‐Amino Acid Derivatives via Matteson Homologation of Boronic Esters

Zeitschrift für anorganische und allgemeine Chemie, Volume 650, Issue 21, November 4, 2024.
Abstract Matteson homologation with sodium azide in DMF proved to be an excellent highly stereoselective tool for the synthesis of complex α‐azido and α‐amino acids. Both enantiomers are easily accessible via the choice of the chiral boronic ester auxiliary.
Alexander Horn, Emanuel Papadopoulos, Thorsten Kinsinger, Jennifer Greve, Etienne Bickel, Stavroula Pachoula, Uli Kazmaier   +6 more
wiley   +1 more source