Results 11 to 20 of about 22,053,927 (171)
Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling
Frontiers in Oncology, 2020 Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis, which is highly expressed in many tumor cells, and has emerged as an important player in tumor progression and metastasis.
Wenjing Guo +14 more
doaj +1 more source
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Nature Communications, 2017 Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and neurodegenerative diseases.
A. Bhardwaj, J. Kaur, M. Wuest, F. Wuest
semanticscholar +1 more source
Journal of Applied Oral Science, 2010 Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process.
Ricardo Nogueira Fracon +3 more
doaj +1 more source
Acta Neuropathologica Communications, 2019 Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2.
Felix Behling +9 more
doaj +1 more source
Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors [PDF]
Genomics & Informatics, 2017 We have previously reported that NS-398, a cyclooxygenase-2 (COX-2)–selective inhibitor, inhibited replicative cellular senescence in human dermal fibroblasts and skin aging in hairless mice. In contrast, celecoxib, another COX-2–selective inhibitor, and
Jeong A. Han, Jong-Il Kim
doaj +1 more source
High brightness CW electron beams from Superconducting RF photoemission gun [PDF]
Phys. Rev. Lett. 124, 244801 (2020), 2020 CW photoinjectors operating at high accelerating gradients promise to revolutionize many areas of science and applications. They can establish the basis for a new generation of monochromatic X-ray free electron lasers, high brightness hadron beams, or a new generation of microchip production.
arxiv +1 more source
Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
Journal of Neuroinflammation, 2019 Epilepsy, a common multifactorial neurological disease, affects about 69 million people worldwide constituting nearly 1% of the world population.
C. Rawat +3 more
semanticscholar +1 more source
Evaluation of cyclooxygenase 2- gene expression in benign and malignant ascites [PDF]
Reviews in Clinical Medicine, 2020 Introduction: This study aimed to evaluate the mRNA expression of cyclooxygenase-2 (Cox-2) in ascites caused by various diseases. Moreover, it was attempted to investigate its usefulness in the differential diagnosis between malignant and benign ascites.
Raheleh Jabini +2 more
doaj +3 more sources
Nutrition and Cancer, 2018 The link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism, is upregulated during both inflammation and cancer.
Shreena Desai, B. Prickril, A. Rasooly
semanticscholar +1 more source
Biomedicines, 2023 The ability of MSCs to modulate the inflammatory environment is well recognized, but understanding the molecular mechanisms responsible for these properties is still far from complete.
Agnieszka Kulesza +2 more
doaj +1 more source