Cell Transplantation, 2019 Ovarian cancer is the leading cause of death among gynecological malignancies. Cyclooxygenase 2 is widely expressed in various cancer cells and participates in the occurrence and development of tumors by regulating a variety of downstream signaling ...
Xiao Zhang +6 more
doaj +2 more sources
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs [PDF]
Circulation, 2014 © 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.BACKGROUND: Cardiovascular ...
Ahmetaj-Shala, Blerina +13 more
core +4 more sources
Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors [PDF]
Jornal de Pediatria, 2006 OBJECTIVE: To analyze selective COX 2 inhibitor nonsteroidal anti-inflammatory drugs (NSAID) in terms of their mechanism of action, principal indications, posology and most common adverse effects.
Hilário, Maria Odete Esteves +2 more
core +5 more sources
Cyclooxygenase-2 Inhibitors. 1,5-Diarylpyrrol-3-acetic Esters with Enhanced Inhibitory Activity toward Cyclooxygenase-2 and Improved Cyclooxygenase-2/Cyclooxygenase-1 Selectivity [PDF]
Journal of Medicinal Chemistry, 2007 The important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates. We previously reported a set of substituted 1,5-diarylpyrrole derivatives, along with their inhibitory activity ...
Biava, M. +17 more
openaire +10 more sources
Cyclooxygenase-2 in glioblastoma multiforme [PDF]
Drug Discovery Today, 2017 Glioblastoma multiforme (GBM) represents the most prevalent brain primary tumor, yet there is a lack of effective treatment. With current therapies, fewer than 5% of patients with GBM survive more than 5 years after diagnosis. Mounting evidence from epidemiological studies reveals that the regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is
Jiange Qiu, Zhi Shi, Jianxiong Jiang
openaire +4 more sources
Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2 [PDF]
Journal of Biological Chemistry, 2000 Here we report the molecular identification of membrane-bound glutathione (GSH)-dependent prostaglandin (PG) E2 synthase (mPGES), a terminal enzyme of the cyclooxygenase (COX)-2-mediated PGE2 biosynthetic pathway.
Makoto Murakami +10 more
openalex +2 more sources
Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
doaj +1 more source
Prostaglandin Synthase 2/Cyclooxygenase 2 Gene Polymorphisms and Susceptibility to Urothelial Bladder Cancer in an Iranian Population [PDF]
Middle East Journal of Cancer, 2022 Background: Prostaglandin-endoperoxide synthase 2, recognized as cyclooxygenase 2 (COX-2), is an important enzyme contributing to the generation of proinflammatory prostaglandins.
Kamyar Mansori +3 more
doaj +1 more source
Endometritis in the bitch: Immunohistochemical localization of cyclooxygenase 2 [PDF]
Open Veterinary Journal, 2020 Background: In several mammals, subfertility or infertility associated with endometritis was reported. Although there have been studies about endometritis in bitches, the pathophysiological mechanisms it is not completely known. Aim: This study aimed to
María Carla García Mitacek +4 more
doaj +1 more source
Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development
Frontiers in Immunology, 2021 Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to known human carcinogens including dioxins can lead to the promotion of breast cancer.
Christoph F. A. Vogel +16 more
doaj +1 more source