Results 121 to 130 of about 106,395 (322)

OPTIMIZING STRUCTURE-BASED VIRTUAL SCREENING PROTOCOL TO IDENTIFY PHYTOCHEMICALS AS CYCLOOXYGENASE-2 INHIBITORS

Indonesian Journal of Pharmacy, 2016
By employing Databases of Useful Decoys (DUD) and its enhanced version (DUD-E), several attempts to construct validated Structure-based Virtual Screening (SBVS) protocols to identify cyclooxygenase-2 (COX-2) inhibitors have been performed. Both databases
Enade Perdana Istyastono
doaj   +1 more source

Computational Analysis and Biological Activities of Oxyresveratrol Analogues, the Putative Cyclooxygenase-2 Inhibitors. [PDF]

Molecules, 2022
Jongkon N, Seaho B, Tayana N, Prateeptongkum S, Duangdee N, Jaiyong P.   +5 more
europepmc   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells

World Journal of Surgical Oncology, 2012
Background Arachidonic acid metabolite, generated by cyclooxygenase (COX), is implicated in the colorectal cancer (CRC) pathogenesis. Inhibiting COX may therefore have anti-carcinogenic effects.
Ganesh Radhakrishnan, Marks Daniel JB, Sales Kevin, Winslet Marc C, Seifalian Alexander M   +4 more
doaj   +1 more source

Novel Benzo[4,5]imidazo[1,2-a]pyrimidine derivatives as selective Cyclooxygenase-2 Inhibitors: Design, synthesis, docking studies, and biological evaluation. [PDF]

Med Chem Res, 2023
Bayanati M, Khoramjouy M, Faizi M, Movahed MA, Mahboubi-Rabbani M, Zarghi A.   +5 more
europepmc   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Stimulatory Action of Cyclooxygenase Inhibitors on Hematopoiesis: A Review

Molecules, 2012
The presented review summarizes experimental data obtained with a mouse model when investigating the relationship between inhibition of prostaglandin production and hematopoiesis.
Lenka Weiterová, Denisa Komůrková, Zuzana Hoferová, Milan Pospíšil, Michal Hofer   +4 more
doaj   +1 more source

Efficacy and safety of cyclooxygenase 2 inhibitors for desmoid tumor management: a systematic review. [PDF]

Nagoya J Med Sci, 2021
Emori M, Matsumoto Y, Murahashi Y, Yoshida M, Nishida Y.   +4 more
europepmc   +1 more source

Electrochemically Driven Tandem In‐Plane Reduction and FeCl3‐ Intercalation of Highly Crystalline Graphene Oxide Thin Films

Advanced Functional Materials, EarlyView.
This study presents a green processing route for high‐performance reduced graphene oxide (rGO) transparent conductive films (TCFs) using highly crystalline Brodie's GO. In‐plane electrochemical reduction forms rGO on insulating substrates without toxic reductants or heat. Subsequent FeCl₃ intercalation enhances conductivity, overcoming the transparency–
Tatsuki Tsugawa, Kazuto Hatakeyama, Junya Kawasaki, Agamoni Pathak, Kazuhito Tsukagoshi, Shintaro Ida, Takaaki Taniguchi   +6 more
wiley   +1 more source

Natural Cyclooxygenase-2 Inhibitors Synergize With Butyrate to Augment Chicken Host Defense Peptide Gene Expression. [PDF]

Front Immunol, 2022
Yang Q, Burkardt AC, Sunkara LT, Xiao K, Zhang G.   +4 more
europepmc   +1 more source