Inhibitors of cyclooxygenase-2-dependent modulation of functional characteristics of leukocytes
RUDN Journal of Medicine, 2009 Cyclooxygenase (COX), the primary enzyme responsible for the synthesis of prostanoids, exists in at least 2 isoforms. COX-2 has been suggested to be the isoform primarily responsible for synthesis of prostaglandins (PGs) in the context of inflammation ...
A V Pasechnik +2 more
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Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors. [PDF]
RSC Adv, 2021 Badawy MAS +4 more
europepmc +1 more source
Basic biology and clinical application of specific cyclooxygenase-2 inhibitors [PDF]
, 2000 Leslie J. Crofford +5 more
openalex +1 more source
Breaking the Selectivity Barrier of Single‐Atom Nanozymes Through Out‐of‐Plane Ligand Coordination
Advanced Materials, EarlyView.Here, Ru SAzyme with out‐of‐plane chlorine ligands is reported as a monofunctional, high‐performance peroxidase‐like nanozyme. Incorporating out‐of‐plane ligand coordination emulates enzyme selectivity and regulates reaction pathways for an identical substrate.
Seonhye Park +8 more
wiley +1 more source
Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane [PDF]
, 2000 Yui Kishimoto
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A Roadmap for Plasma‐Enabled Electrocatalysis in Urea Production
Advanced Materials, EarlyView.A modular plasma—electrochemical platform enables fully electrified urea synthesis from air and CO2 under ambient conditions. This Review integrates plasma oxidation, C─N coupling electrolysis, mechanistic insights, and techno‐economic metrics into a roadmap for scalable, distributed, and renewable fertilizer production.
Jingwen Huang +6 more
wiley +1 more source
Preemptive analgesia using selective cyclooxygenase-2 inhibitors alleviates postoperative pain in patients undergoing total knee arthroplasty: A protocol for PRISMA guided meta-analysis of randomized controlled trials. [PDF]
Medicine (Baltimore), 2021 Wang C, Fu H, Wang J, Huang F, Cao X.
europepmc +1 more source
Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery
Advanced Science, EarlyView.Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou +8 more
wiley +1 more source
Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors. [PDF]
ACS Med Chem Lett, 2020 Uddin MJ +6 more
europepmc +1 more source