Results 231 to 240 of about 105,678 (295)

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

Design, Synthesis, and In Vitro Enzymatic Evaluation of Novel Flavone Derivatives as Dual COX-2/5-LOX Inhibitors Supported by Molecular Docking and ADMET Analysis. [PDF]

Curr Issues Mol Biol
Fraj E, Elbouzidi A, Bouammali H, Jaouani H, Bourhou C, Addi M, Zughaier SM, Challioui A, Touzani R, Bouammali B.   +9 more
europepmc   +1 more source

Mature Tertiary Lymphoid Structures Indicate Good Chemotherapy Response and Prognosis in Advanced Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
In advanced colorectal cancer, tumors with mature tertiary lymphoid structures (TLS) exhibited abundant infiltration of CD3‐ and CD8‐positive lymphocytes in both primary and metastatic sites, indicating an activated immune response. The presence of mature TLS was also associated with favorable chemotherapy sensitivity and improved prognosis.
Nobuhiro Hosoi, Chika Komine, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

Chrysotoxine Attenuates Key Atherogenic Processes via Antioxidant, Anti-Inflammatory, and COX-Dependent Antiplatelet Mechanisms. [PDF]

Biomolecules
Rustamani F, Swe HN, Thant SW, Moonrut J, Sritularak B, Rojnuckarin P, Nalinratana N, Luechapudiporn R.   +7 more
europepmc   +1 more source

High-dose folic acid supplement is associated with increased cardiovascular risk in rheumatoid arthritis patients on methotrexate. [PDF]

Ther Adv Musculoskelet Dis
Meng H, So H, Yan X, Jin Y, Lam SH, Kwok T, Tam LS.   +6 more
europepmc   +1 more source

Computational strategies for unraveling insights from known inhibitors for further lead optimization: A case study on Celecoxib analogues. [PDF]

Sci Rep
Grewal S, Ghosh B, Narayan U, Aparoy P.
europepmc   +1 more source

Anti-Inflammatory Activity of Cyclic Imide Derivatives. [PDF]

Pharmaceuticals (Basel)
Redzicka A, Tylińska B, Wójcicka A.
europepmc   +1 more source