Results 231 to 240 of about 106,395 (322)

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

Advanced Science, EarlyView.
Pinosylvin blocks LPS and RANKL induced NEK7/NLRP3 interaction, inhibiting NLRP3 inflammasome oligomerization and assembly, reducing IL‐1β maturation and GSDMD cleavage, and improving the inflammatory microenvironment and abnormal osteoclastogenesis. Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and
Wei Zhang, Xiangbing Wu, Wenming Li, Haifeng Zhang, Yijun Wang, Jing Xu, Wenhao Li, Yi Qin, Zebin Wu, Gaoran Ge, Shujun Lv, Lu Mao, Liangliang Wang, Dechun Geng   +13 more
wiley   +1 more source

COX-2: Where are we in 2003? - Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease. [PDF]

, 2002
Leslie J. Crofford
openalex   +1 more source

Coactosin‐Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation

Advanced Science, EarlyView.
Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.
Li‐Long Pan, Zhengnan Ren, Binbin Li, Wenjie Liang, Yang Luo, Qin Yang, He Liu, Xiaoliang Dong, Haizhi Tian, Huimin Zou, Bengt Samuelsson, Olof Rådmark, Jia Sun   +12 more
wiley   +1 more source

Efficacy Assessment of Meloxicam, a Preferential Cyclooxygenase-2 Inhibitor, in Acute Coronary Syndromes Without ST-Segment Elevation [PDF]

, 2002
Raúl Altman, Héctor Luciardi, Juan Muntaner, Fatima Del Rio, Sofía Berman, Rubén López, Claudio Gónzalez   +6 more
openalex   +1 more source

Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate‐GPR109A‐GSDMD Axis

Advanced Science, EarlyView.
Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua, Ning Ding, Yiming Hua, Xiaoke Wang, Yu Xu, Xiangrui Qiao, Xue Shi, Ting Bai, Ying Xiong, Xiaozhen Zhuo, Chong Fan, Juan Zhou, Yue Wu, Junhui Liu, Zuyi Yuan, Ting Li   +15 more
wiley   +1 more source

Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis

, 2001
Carla Zoja, Ariela Benigni, Marina Noris, Daniela Corna, Federica Casiraghi, Marcella Pagnoncelli, Daniela Rottoli, Mauro Abbate, Giuseppe Remuzzi   +8 more
openalex   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

Structure-activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009-2016). [PDF]

Medchemcomm, 2017
Carullo G, Galligano F, Aiello F.
europepmc   +1 more source

A Cyclooxygenase-2 Inhibitor (SC-58125) Blocks Growth of Established Human Colon Cancer Xenografts

, 2001
Christopher S. Williams, Hongmiao Sheng, Jeffrey A. Brockman, Radhika Armandla, Jinyi Shao, M. Kay Washington, Abdel Elkahloun, Raymond N. DuBois   +7 more
openalex   +1 more source

Beneficial Effect of Nonsteroidal Anti‐inflammatory Drugs and Cyclooxygenase‐2 Inhibitors in Patients with Asthma during Viral Infection [PDF]

, 2002
Arthur E. Varner
openalex   +1 more source