Results 91 to 100 of about 50,064 (212)

Proteomics reveals that a high-fat diet induces rapid changes in hypothalamic proteins related to neuronal damage and inflammation [PDF]

, 2011
Peer reviewedPublisher ...
Campbell, F. M., Grant, C., Hoggard, N., Koch, C., Morris, A. C., Nicol, F., Nicol, P., Reid, M., Tups, A., Williams, L. M.   +9 more
core   +1 more source

Unlocking the Door to Neuronal Woes in Alzheimer’s Disease: Aβ and Mitochondrial Permeability Transition Pore

Pharmaceuticals, 2010
Mitochondrial dysfunction occurs early in the progression of Alzheimer’s disease. Amyloid-β peptide has deleterious effects on mitochondrial function and contributes to energy failure, respiratory chain impairment, neuronal apoptosis, and generation of ...
Heng Du, Shirley ShiDu Yan
doaj   +1 more source

The cis/trans interconversion of the calcium regulating hormone calcitonin is catalyzed by cyclophilin [PDF]

, 1993
The cytosolic peptidyl-prolyl cis/trans isomerase cyclophilin from pig kidney can accelerate catalytically the cis/trans isomerization of prolyl peptide bonds.
Fischer, Lang, Bä, Lang, Fischer, Takahashi, Hohman, Harding, Friedman, Liu, Lin, Azria, Hü, Sandströ, Baine, Wü, Wü, Jeener, Hsu, London, Kö, Epstein, Schlosberg, Choe   +23 more
core   +1 more source

Insights into the Roles of Cyclophilin A During Influenza Virus Infection

Viruses, 2013
Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the
Wenjun Liu, Zhendong Zhao, Xiaoling Liu
doaj   +1 more source

SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells [PDF]

, 2011
Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS. Methods: In this study, we ...
Betty A. Wu-Hsieh, Chuan-Liang Kao, Sher Singh, Wan-Jiung(Wan-Chung) Hu, Yu-Ting Yen   +4 more
core   +1 more source

Cyclophilin A: A Mediator of Cardiovascular Pathology

Journal of the Korean Society of Hypertension, 2011
Cyclophilin A (CyPA) is a 17 kDa, ubiquitously expressed multifunctional protein that possesses peptidylprolyl cis-trans isomerase activity and scaffold function. Its expression is increased in inflammatory conditions including rheumatoid arthritis, autoimmune disease and cancer.
Nwe Nwe Soe, Bradford C. Berk
openaire   +1 more source

Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury [PDF]

, 2019
TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia.
Choi, Soo Youn, Kang, Hyun Je, Kwon, Hyug Moo, Kwon, Mi Jin, Lee-Kwon, Whaseon, Lim, Sun Woo, Nam, Dougu, Park, Hyun, Sanada, Satoru, Yoo, Eun Jin, Yoon, Sora   +10 more
core   +1 more source

Cyclophilin A: promising target in cancer therapy

Cancer Biology & Therapy
Cyclophilin A (CypA), a member of the immunophilin family, stands out as the most prevalent among the cyclophilins found in humans. Beyond serving as the intracellular receptor for the immunosuppressive drug cyclosporine A (CsA), CypA exerts critical functions within the cell via its peptidyl-prolyl cis-trans isomerase (PPIase) activity, which is ...
Shujuan Jin, Mengjiao Zhang, Xiaoting Qiao   +2 more
openaire   +3 more sources

Ezetimibe therapy: mechanism of action and clinical update. [PDF]

, 2012
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D, Phan, Binh An P, Toth, Peter P   +2 more
core   +1 more source

Calmodulin, Cyclophilin, and Cyclosporin A [PDF]

Science, 1986
W N, Hait, M W, Harding, R E, Handschumacher   +2 more
openaire   +2 more sources