Computational modeling of In vitro swelling of mitochondria: A biophysical approach [PDF]
, 2018 Swelling of mitochondria plays an important role in the pathogenesis of human diseases by stimulating mitochondria-mediated cell death through apoptosis, necrosis, and autophagy.
Javadov, Sabzali +2 more
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In silico simulation of reversible and irreversible swelling of mitochondria: The role of membrane rigidity [PDF]
, 2020 Mitochondria have been widely accepted as the main source of ATP in the cell. The inner mitochondrial membrane (IMM) is important for the maintenance of ATP production and other functions of mitochondria.
Arieli +48 more
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Cloning and characterization of a Streptomyces antibioticus ATCC11891 cyclophilin related to Gram negative bacteria cyclophilins [PDF]
FEBS Letters, 2004 Cyclophilins are folding helper enzymes and represent a family of the enzyme class of peptidyl‐prolyl cis–trans isomerases. Here, we report the molecular cloning and biochemical characterization of SanCyp18, an 18‐kDa cyclophilin from Streptomyces antibioticus ATCC11891 located in the cytoplasm and constitutively expressed during development.
Manteca, Angel +4 more
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Parasites & Vectors, 2015 Background Cyclophilin A (CyPA), a ubiquitously distributed intracellular protein, is thought to be one of the important inflammatory factors and plays a significant role in the development process of sepsis.
Tianzhang Song +7 more
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Cyclophilin A and CD147: novel therapeutic targets for the treatment of COVID-19
Medicine in Drug Discovery, 2020 The outbreak of pneumonia caused by a new coronavirus (SARS-CoV-2) occurred in December 2019, and spread rapidly throughout the world. There have been other severe coronavirus outbreaks worldwide, namely, severe acute respiratory syndrome (SARS-CoV) and ...
Chenglong Liu +2 more
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Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization [PDF]
, 2017 PURPOSE: Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference.
Aversa, Antonio +8 more
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Cyclophilin and Viruses: Cyclophilin as a Cofactor for Viral Infection and Possible Anti-Viral Target [PDF]
Drug Target Insights, 2007 Cyclophilin (CyP) is a peptidyl prolyl cis/trans isomerase, catalyzing the cis-trans isomerization of proline residues in proteins. CyP plays key roles in several different aspects of cellular physiology including the immune response, transcription, mitochondrial function, cell death, and chemotaxis.
Koichi Watashi, Kunitada Shimotohno
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Inflammation and Regeneration, 2023 Background Testosterone contributes to male organism development, such as bone density, muscle development, and fat repartition. Estrogen (derived from testosterone) also contributes to female reproductive system development.
Kouminin Kanwore +12 more
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Biosynthesis and enzymology of the Caenorhabditis elegans cuticle: identification and characterization of a novel serine protease inhibitor. [PDF]
, 2006 The nematode Caenorhabditis elegans represents an excellent model in which to examine nematode gene expression and function. A completed genome, straightforward transgenesis, available mutants and practical genome-wide RNAi approaches provide an ...
Andrew J. Birnie +42 more
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BPTF Enhances Chemotherapy Induced Cytotoxicity [PDF]
, 2020 BPTF Enhances Chemotherapy Induced Cytotoxicity Valentina Posada, Depts. of Biology, Chemistry, & Religious Studies, with Dr. Joseph Landry, Dept. of Human Molecular Genetics New chemotherapies and immunotherapy treatments have greatly improved the ...
Posada, Valentina
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