Results 101 to 110 of about 45,384 (211)

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, EarlyView.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source

Cyclophilin–CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8

Frontiers in Immunology
Monocytes and macrophages, as important constituents of the innate immune system, are equipped with multiple Toll-like-receptors (TLRs) to recognize invading pathogens, such as SARS-CoV-2, and mount an antiviral response. Nevertheless, their uncontrolled
Gabor Tajti, Laura Gebetsberger, Gregor Pamlitschka, Katharina Aigner-Radakovics, Judith Leitner, Peter Steinberger, Hannes Stockinger, Anna Ohradanova-Repic   +7 more
doaj   +1 more source

Structural Basis of Cyclophilin B Binding by the Calnexin/Calreticulin P-domain [PDF]

Journal of Biological Chemistry, 2010
Little is known about how chaperones in the endoplasmic reticulum are organized into complexes to assist in the proper folding of secreted proteins. One notable exception is the complex of ERp57 and calnexin that functions as part the calnexin cycle to direct disulfide bond formation in N-glycoproteins.
Guennadi, Kozlov, Sara, Bastos-Aristizabal, Pekka, Määttänen, Angelika, Rosenauer, Fenglin, Zheng, April, Killikelly, Jean-François, Trempe, David Y, Thomas, Kalle, Gehring   +8 more
openaire   +2 more sources

Piscirickettsiosis in Farmed Turbot, Scophthalmus maximus

Journal of Fish Diseases, EarlyView.
ABSTRACT Piscirickettsia salmonis is a well‐established intracellular pathogen of farmed Atlantic salmon around the world. The bacterium has also been detected from a number of other hosts including lumpfish (Cyclopterus lumpus), seabass (Dicentrarchus labrax) and rainbow trout (Oncorhynchus mykiss).
Hanne K. Nilsen, Magne Kjerulf Hansen, Raoul Kuiper, Jan Inge Øvrebø, Kjersti Sturød, Maryam Saghafian, Snorre Gulla, Anne Berit Olsen, Duncan J. Colquhoun, Ole Bendik Dale   +9 more
wiley   +1 more source

Proteomic profiling of SupT1 cells reveal modulation of host proteins by HIV-1 Nef variants. [PDF]

PLoS ONE, 2015
Nef is an accessory viral protein that promotes HIV-1 replication, facilitating alterations in cellular pathways via multiple protein-protein interactions.
Reshu Saxena, Sudipti Gupta, Kavita Singh, Kalyan Mitra, Anil Kumar Tripathi, Raj Kamal Tripathi   +5 more
doaj   +1 more source

Sequencing and analysis of the gastrula transcriptome of the brittle star Ophiocoma wendtii [PDF]

, 2012
Background The gastrula stage represents the point in development at which the three primary germ layers diverge. At this point the gene regulatory networks that specify the germ layers are established and the genes that define the differentiated states ...
Garey, James R., Garnhart, Nancy, Livingston, Brian T., Thomas, W. Kelley, Vaughn, Roy   +4 more
core   +2 more sources

Cyclophilins A and B Oppositely Regulate Renal Tubular Epithelial Phenotype [PDF]

, 2018
AbstractCyclophilins (Cyp) are peptidil-prolyl-isomerases and the intracellular receptors for the immunosuppressant Cyclosporine-A (CsA), which produces epithelial-mesenchymal-transition (EMT) and renal tubule-interstitial fibrosis. Since CsA inhibits Cyp enzymatic activity, we hypothesized that Cyp could be involved in EMT and fibrosis.
Sarró, Eduard, Durán, Mónica, Rico, Ana, Croatt, Anthony J., Nath, Karl A., Teresa, Salcedo Maria, Gundelach, Justin H., Batlle, Daniel, Bram, Richard J., Meseguer, Anna   +9 more
openaire   +1 more source

The GmGT‐2F, a trihelix transcription factor, regulates seed oil content by directly activating GmAGAL transcription in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, the trihelix transcription factor GmGT‐2F positively regulates the expression of the α‐galactosidase gene GmAGAL, thereby modulating seed oil content. The cyclophilin GmCYP2 interacts with GmGT‐2F and suppresses GmAGAL activation. Haplotype diversity analysis of GmGT‐2F, GmCYP2, and GmAGAL identified favorable haplotype combinations ...
Shuangzhe Li, Yifan Cui, Yang Liu, Mingliang Yang, Xiaoxia Wu, Qingshan Chen, Ying Zhao   +6 more
wiley   +1 more source

Cyclophilin B Expression Is Associated with In Vitro Radioresistance and Clinical Outcome after Radiotherapy

Neoplasia: An International Journal for Oncology Research, 2011
The tools for predicting clinical outcome after radiotherapy are not yet optimal. To improve on this, we applied the COXEN informatics approach to in vitro radiation sensitivity data of transcriptionally profiled human cells and gene expression data from
Paul D. Williams, Charles R. Owens, Jaroslaw Dziegielewski, Christopher A. Moskaluk, Paul W. Read, James M. Larner, Michael D. Story, William A. Brock, Sally A. Amundson, Jae K. Lee, Dan Theodorescu   +10 more
doaj   +1 more source

Novel roles of sulfur metabolism in stress‐controlled stomata aperture regulation

New Phytologist, EarlyView.
Summary Stomatal closure allows plants to conserve water by reducing transpiration during drought. Surprisingly, the assimilation of the macronutrient sulfur is intimately connected to the drought stress response. This Tansley insight will only briefly touch on the general impact of sulfate assimilation on the production of drought‐response metabolites.
Sheng‐Kai Sun, Rüdiger Hell, Markus Wirtz   +2 more
wiley   +1 more source