Results 171 to 180 of about 45,384 (211)

Broad-Spectrum Antiviral Activity of Cyclophilin Inhibitors Against Coronaviruses: A Systematic Review. [PDF]

open access: yesInt J Mol Sci
Elhabyan A   +8 more
europepmc   +1 more source

Direct-to-Biology Enabled Molecular Glue Discovery. [PDF]

open access: yesJ Am Chem Soc
Hu M   +21 more
europepmc   +1 more source

Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model. [PDF]

open access: yesJ Med Chem
Awais M   +18 more
europepmc   +1 more source

Cyclophilin B Deficiency Causes Abnormal Dentin Collagen Matrix

Journal of Proteome Research, 2017
Cyclophilin B (CypB) is an endoplasmic reticulum-resident protein that regulates collagen folding, and also contributes to prolyl 3-hydroxylation (P3H) and lysine (Lys) hydroxylation of collagen. In this study, we characterized dentin type I collagen in CypB null (KO) mice, a model of recessive osteogenesis imperfecta type IX, and compared to those of ...
Masahiko, Terajima   +7 more
openaire   +2 more sources

CD147 Is a Signaling Receptor for Cyclophilin B

Biochemical and Biophysical Research Communications, 2001
Cyclophilins A and B (CyPA and CyPB) are cyclosporin A binding proteins that can be secreted in response to inflammatory stimuli. We recently identified CD147 as a cell-surface receptor for CyPA and demonstrated that CD147 is an essential component in the CyPA-initiated signaling cascade that culminates in ERK activation and chemotaxis.
V, Yurchenko   +6 more
openaire   +2 more sources

Fluorescence Characterization of the Hydrophobic Pocket of Cyclophilin B

Journal of Fluorescence, 2007
Human cyclophilin B is a monomeric protein that contains two tryptophan residues, Trp104 and 128. Trp128-residue belongs to the binding site of cyclosporin A and is the homologous of Trp 121 in CyPA, while Trp104 residue belongs to the hydrophobic pocket.
J R, Albani, M, Carpentier, C, Lansiaux
openaire   +2 more sources

Molecular Cloning and Characterization of Aspergillus nidulans Cyclophilin B

Fungal Genetics and Biology, 1999
Cyclophilins are an evolutionarily conserved family of proteins which serve as the intracellular receptors for the immunosuppressive drug cyclosporin A. Here we report the characterization of the first cyclophilin cloned from the filamentous fungus Aspergillus nidulans (CYPB).
J D, Joseph, J, Heitman, A R, Means
openaire   +2 more sources

Honokiol inhibits hepatoma carcinoma cell migration through downregulated Cyclophilin B expression

Biochemical and Biophysical Research Communications, 2021
Hepatocellular carcinoma (HCC) is the fifth common types of cancer with poor prognosis in the world. Honokiol (HNK), a natural biphenyl compound derived from the magnolia plant, has been reported to exert anticancer effects, but its mechanism has not been elucidated exactly.
Young-Seok Lee   +8 more
openaire   +2 more sources

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