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Broad-Spectrum Antiviral Activity of Cyclophilin Inhibitors Against Coronaviruses: A Systematic Review. [PDF]
Elhabyan A +8 more
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Direct-to-Biology Enabled Molecular Glue Discovery. [PDF]
Hu M +21 more
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Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model. [PDF]
Awais M +18 more
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Cyclophilin B Deficiency Causes Abnormal Dentin Collagen Matrix
Journal of Proteome Research, 2017Cyclophilin B (CypB) is an endoplasmic reticulum-resident protein that regulates collagen folding, and also contributes to prolyl 3-hydroxylation (P3H) and lysine (Lys) hydroxylation of collagen. In this study, we characterized dentin type I collagen in CypB null (KO) mice, a model of recessive osteogenesis imperfecta type IX, and compared to those of ...
Masahiko, Terajima +7 more
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CD147 Is a Signaling Receptor for Cyclophilin B
Biochemical and Biophysical Research Communications, 2001Cyclophilins A and B (CyPA and CyPB) are cyclosporin A binding proteins that can be secreted in response to inflammatory stimuli. We recently identified CD147 as a cell-surface receptor for CyPA and demonstrated that CD147 is an essential component in the CyPA-initiated signaling cascade that culminates in ERK activation and chemotaxis.
V, Yurchenko +6 more
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Fluorescence Characterization of the Hydrophobic Pocket of Cyclophilin B
Journal of Fluorescence, 2007Human cyclophilin B is a monomeric protein that contains two tryptophan residues, Trp104 and 128. Trp128-residue belongs to the binding site of cyclosporin A and is the homologous of Trp 121 in CyPA, while Trp104 residue belongs to the hydrophobic pocket.
J R, Albani, M, Carpentier, C, Lansiaux
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Molecular Cloning and Characterization of Aspergillus nidulans Cyclophilin B
Fungal Genetics and Biology, 1999Cyclophilins are an evolutionarily conserved family of proteins which serve as the intracellular receptors for the immunosuppressive drug cyclosporin A. Here we report the characterization of the first cyclophilin cloned from the filamentous fungus Aspergillus nidulans (CYPB).
J D, Joseph, J, Heitman, A R, Means
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Honokiol inhibits hepatoma carcinoma cell migration through downregulated Cyclophilin B expression
Biochemical and Biophysical Research Communications, 2021Hepatocellular carcinoma (HCC) is the fifth common types of cancer with poor prognosis in the world. Honokiol (HNK), a natural biphenyl compound derived from the magnolia plant, has been reported to exert anticancer effects, but its mechanism has not been elucidated exactly.
Young-Seok Lee +8 more
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