Results 131 to 140 of about 687 (168)

Medical problems in military personnel associated with burn pit exposure: a narrative review. [PDF]

J Thorac Dis
Tran V, Shihab T, Alapati A, Nugent C, Nugent R, Nugent K.   +5 more
europepmc   +1 more source

Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases. [PDF]

ACS Med Chem Lett
Knittelova K, Prchalova E, Fuchsova A, Andrys R, Kohoutova Z, Rademacherova S, Prchal L, Musilek K, Malinak D.   +8 more
europepmc   +1 more source

Environmentally Friendly Nanocoating for Rapid Detection of Nerve Agents on Textile Fabric. [PDF]

ACS Omega
Jordanov I, Dimova V, Geskovski N, Mirakovski D.   +3 more
europepmc   +1 more source

Genomic interplay between deployment exposures and Gulf War illness in Million Veteran Program participants. [PDF]

Hum Genomics
Qiu D, Cabrera-Mendoza B, He J, Steele L, Quaden R, Harrington KM, Ahmed ST, Gaziano JM, Gifford EJ, Aslan M, Helmer DA, Hauser ER, Polimanti R, Department of Veterans Affairs Cooperative Studies Program #2006 and VA Million Veteran Program.   +13 more
europepmc   +1 more source

Reactivation of Cyclosarin-inhibited Rat Brain Acetylcholinesterase by Pyridinium–Oximes [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2004
Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which is resistant to conventional oxime therapy. To gain insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibited in vitro by cyclosarin (pH 8.0, 25 degrees C) and reactivated with 22 different pyridiniumoximes.
Kamil Kuča
exaly   +3 more sources

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In vitro detoxification of cyclosarin (GF) by modified cyclodextrins

Toxicology Letters, 2011
Developing potent detoxification strategies for prophylaxis and therapy against organophosphate (OP) intoxication still represents a challenging task. Clinical application of numerous investigated substances including enzymes and low molecular scavengers like metal ions or nucleophiles could not yet be realised due to profound disadvantages. Presenting
Müller, Susanne, Koller, Marianne, Le Provost, Romain, Lafont, Olivier, Estour, François, Wille, Timo, Thiermann, Horst, Worek, Franz, Reiter, Georg   +8 more
openaire   +4 more sources

Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans [PDF]

NeuroToxicology, 2014
More than 100,000 US troops were potentially exposed to chemical warfare agents sarin (GB) and cyclosarin (GF) when an ammunition dump at Khamisiyah, Iraq was destroyed during the 1991 Gulf War (GW). We previously reported reduced hippocampal volume in GW veterans with suspected GB/GF exposure relative to matched, unexposed GW veterans estimated from 1.
Stephen Kriger, Susanne G Mueller, Peter Ng   +2 more
exaly   +3 more sources

In vitro toxicokinetic studies of cyclosarin: Molecular mechanisms of elimination

Toxicology Letters, 2014
The toxicokinetics of in vitro elimination of highly toxic cyclosarin (GF) in biological systems revealed striking stereoselective differences in the range of 0.01μM to 1mM GF. While weak concentration dependency was detected for elimination of the toxic (-)-enantiomer indicating catalytic processes, elimination of less toxic (+)-GF followed unusual ...
Georg, Reiter, Susanne, Müller, Marianne, Koller, Horst, Thiermann, Franz, Worek   +4 more
openaire   +2 more sources

Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo

Toxicology Letters, 2014
Standard treatment of poisoning by organophosphorus (OP) nerve agents with atropine and an oxime has a limited efficacy. An alternative approach is the development of stoichiometric or catalytic (bio-)scavengers which should be able to prevent systemic toxicity. Recently, a β-cyclodextrin derivative, 6-OxP-CD, bearing a pyridinium oximate in 6-position
Franz, Worek, Thomas, Seeger, Michael, Zengerle, Stefan, Kubik, Horst, Thiermann, Timo, Wille   +5 more
openaire   +2 more sources

New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2006
Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7). AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication with these agents.
Kamil Kuča, Daniel Jun, Kamil Musílek
exaly   +3 more sources