Results 151 to 160 of about 687 (168)
Some of the next articles are maybe not open access.
Journal of Applied Toxicology, 2005
AbstractIn our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme.
Kamil, Kuca +5 more
openaire +2 more sources
AbstractIn our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme.
Kamil, Kuca +5 more
openaire +2 more sources
Chemical Research in Toxicology, 2014
The inactivation of acetylcholinesterase (AChE) by organophosphorus agent (OP) compounds is a serious problem regardless of how the individual was exposed. The reactivation of OP-inactivated AChE is dependent on the OP conjugate, and commonly a specific oxime is better at reactivating a specific OP conjugate than several diverse OP conjugates.
Emilio Xavier, Esposito +3 more
openaire +2 more sources
The inactivation of acetylcholinesterase (AChE) by organophosphorus agent (OP) compounds is a serious problem regardless of how the individual was exposed. The reactivation of OP-inactivated AChE is dependent on the OP conjugate, and commonly a specific oxime is better at reactivating a specific OP conjugate than several diverse OP conjugates.
Emilio Xavier, Esposito +3 more
openaire +2 more sources
Toxicology in Vitro, 2015
The well-established dynamic in vitro model for the real-time determination of acetylcholinesterase activity was modified for use of human butyrylcholinesterase (BChE) activity. Human plasma as BChE source was layered on a syringe filter and the enzyme reactor was continuously perfused with phosphate buffer, butyrylthiocholine and Ellman’s reagent at ...
Franz, Worek +3 more
openaire +2 more sources
The well-established dynamic in vitro model for the real-time determination of acetylcholinesterase activity was modified for use of human butyrylcholinesterase (BChE) activity. Human plasma as BChE source was layered on a syringe filter and the enzyme reactor was continuously perfused with phosphate buffer, butyrylthiocholine and Ellman’s reagent at ...
Franz, Worek +3 more
openaire +2 more sources
Sensors and Actuators B: Chemical, 2013
Abstract A sensitive nanopore-based analytical method was developed for the detection of cyclohexyl methylphosphonic acid (CMPA) and pinacolyl methylphosphonate (PMPA), hydrolytes of nerve agents soman and cyclosarin, respectively. The method uses a multi-functionalized α-hemolysin protein ion channel as the sensing element, with a host molecule β ...
Jyoti Gupta +4 more
openaire +1 more source
Abstract A sensitive nanopore-based analytical method was developed for the detection of cyclohexyl methylphosphonic acid (CMPA) and pinacolyl methylphosphonate (PMPA), hydrolytes of nerve agents soman and cyclosarin, respectively. The method uses a multi-functionalized α-hemolysin protein ion channel as the sensing element, with a host molecule β ...
Jyoti Gupta +4 more
openaire +1 more source
Chemical Papers, 2006
AbstractNine potential AChE reactivators were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the previous results, 1,4-bis(2-hydroxyiminomethylpyridinium)butane dibromide seems to be the most potent AChE reactivator.
K. Musílek +6 more
openaire +1 more source
AbstractNine potential AChE reactivators were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the previous results, 1,4-bis(2-hydroxyiminomethylpyridinium)butane dibromide seems to be the most potent AChE reactivator.
K. Musílek +6 more
openaire +1 more source
Inhalation Toxicology, 2006
This study tested and optimized various methodologies to generate, sample, and characterize GB and GF test atmospheres in an inhalation chamber, particularly at low vapor levels. A syringe drive/spray atomization system produced vapor concentrations at a range of 1-50 mg/m3.
William T, Muse +3 more
openaire +2 more sources
This study tested and optimized various methodologies to generate, sample, and characterize GB and GF test atmospheres in an inhalation chamber, particularly at low vapor levels. A syringe drive/spray atomization system produced vapor concentrations at a range of 1-50 mg/m3.
William T, Muse +3 more
openaire +2 more sources
Effect of 10 oxime cholinesterase reactivators on cyclosarin-intoxicated rats
Toxicology Letters, 2009Jana Zdarova Karasova +4 more
openaire +1 more source
Sensing cyclosarin (a chemical warfare agent) by Cucurbit[n]urils: A DFT/TD-DFT study
Journal of Molecular Structure, 2023Haamid Rasool Bhat +2 more
openaire +1 more source