Results 141 to 150 of about 674 (166)
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Toxicology Letters, 2013
Cyclodextrins (CD) are promising small molecular scavengers showing favourable degradation of extremely toxic organophosphorus compounds (OP) such as tabun (GA), soman (GD) or cyclosarin (GF). For β-CD derivatives as potential OP antidotes with low intrinsic toxicity it is of great interest to completely understand the modes of interaction of both ...
Andreas, Kranawetvogl +5 more
openaire +2 more sources
Cyclodextrins (CD) are promising small molecular scavengers showing favourable degradation of extremely toxic organophosphorus compounds (OP) such as tabun (GA), soman (GD) or cyclosarin (GF). For β-CD derivatives as potential OP antidotes with low intrinsic toxicity it is of great interest to completely understand the modes of interaction of both ...
Andreas, Kranawetvogl +5 more
openaire +2 more sources
Clinical Toxicology, 2007
Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotal therapy of organophosphorus pesticide and nerve agent intoxications. Cyclosarin is one member of the nerve agent family. In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS ...
Kamil Kuca +2 more
exaly +3 more sources
Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotal therapy of organophosphorus pesticide and nerve agent intoxications. Cyclosarin is one member of the nerve agent family. In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS ...
Kamil Kuca +2 more
exaly +3 more sources
The therapeutic efficacy of oxime treatment in cyclosarin-poisoned mice pretreated with a combination of pyridostigmine benactyzine and trihexyphenidyl [PDF]
Journal of Applied Biomedicine, 2004 Summary The present study was performed to assess and compare the therapeutic efficacy of various oximes (methoxime, BI-6, HI-6) combined with benactyzine (BNZ) in cyclosarin (GF-agent)-poisoned mice and to evaluate the influence of pretreatment with PANPAL (pyridostigmine, benactyzine and trihexyphenidyl) on the effect of antidotal treatment in mice ...
Kamil Kuca
exaly +2 more sources
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2007
The present study was initiated to develop a sensitive method for the analysis of cyclosarin (O-cyclohexyl methylphosphonofluoridate, GF) enantiomers in biological samples utilizing classical configurations of GC-MS and automated solid phase extraction.
Frédéric Dorandeu +2 more
exaly +3 more sources
The present study was initiated to develop a sensitive method for the analysis of cyclosarin (O-cyclohexyl methylphosphonofluoridate, GF) enantiomers in biological samples utilizing classical configurations of GC-MS and automated solid phase extraction.
Frédéric Dorandeu +2 more
exaly +3 more sources
Chemical Research in Toxicology
We have assessed the human liver microsomal (HLM) metabolism of the chemical warfare nerve agents' sarin (GB), cyclosarin (GF), and the Novichok agents A-230 and A-232. In HLM, GB showed drastically decreased stability (t1/2 = 1.4 h). The addition of ethylenediaminetetraacetic acid (EDTA), which inhibits paraoxonase-1 (PON1), reduced the metabolism of ...
Thomas R. Lane +5 more
openaire +2 more sources
We have assessed the human liver microsomal (HLM) metabolism of the chemical warfare nerve agents' sarin (GB), cyclosarin (GF), and the Novichok agents A-230 and A-232. In HLM, GB showed drastically decreased stability (t1/2 = 1.4 h). The addition of ethylenediaminetetraacetic acid (EDTA), which inhibits paraoxonase-1 (PON1), reduced the metabolism of ...
Thomas R. Lane +5 more
openaire +2 more sources
Journal of Applied Toxicology, 2005
AbstractIn our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme.
Kamil, Kuca +5 more
openaire +2 more sources
AbstractIn our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme.
Kamil, Kuca +5 more
openaire +2 more sources
Chemical Research in Toxicology, 2014
The inactivation of acetylcholinesterase (AChE) by organophosphorus agent (OP) compounds is a serious problem regardless of how the individual was exposed. The reactivation of OP-inactivated AChE is dependent on the OP conjugate, and commonly a specific oxime is better at reactivating a specific OP conjugate than several diverse OP conjugates.
Emilio Xavier, Esposito +3 more
openaire +2 more sources
The inactivation of acetylcholinesterase (AChE) by organophosphorus agent (OP) compounds is a serious problem regardless of how the individual was exposed. The reactivation of OP-inactivated AChE is dependent on the OP conjugate, and commonly a specific oxime is better at reactivating a specific OP conjugate than several diverse OP conjugates.
Emilio Xavier, Esposito +3 more
openaire +2 more sources
Toxicology in Vitro, 2015
The well-established dynamic in vitro model for the real-time determination of acetylcholinesterase activity was modified for use of human butyrylcholinesterase (BChE) activity. Human plasma as BChE source was layered on a syringe filter and the enzyme reactor was continuously perfused with phosphate buffer, butyrylthiocholine and Ellman’s reagent at ...
Franz, Worek +3 more
openaire +2 more sources
The well-established dynamic in vitro model for the real-time determination of acetylcholinesterase activity was modified for use of human butyrylcholinesterase (BChE) activity. Human plasma as BChE source was layered on a syringe filter and the enzyme reactor was continuously perfused with phosphate buffer, butyrylthiocholine and Ellman’s reagent at ...
Franz, Worek +3 more
openaire +2 more sources
Sensors and Actuators B: Chemical, 2013
Abstract A sensitive nanopore-based analytical method was developed for the detection of cyclohexyl methylphosphonic acid (CMPA) and pinacolyl methylphosphonate (PMPA), hydrolytes of nerve agents soman and cyclosarin, respectively. The method uses a multi-functionalized α-hemolysin protein ion channel as the sensing element, with a host molecule β ...
Jyoti Gupta +4 more
openaire +1 more source
Abstract A sensitive nanopore-based analytical method was developed for the detection of cyclohexyl methylphosphonic acid (CMPA) and pinacolyl methylphosphonate (PMPA), hydrolytes of nerve agents soman and cyclosarin, respectively. The method uses a multi-functionalized α-hemolysin protein ion channel as the sensing element, with a host molecule β ...
Jyoti Gupta +4 more
openaire +1 more source
Chemical Papers, 2006
AbstractNine potential AChE reactivators were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the previous results, 1,4-bis(2-hydroxyiminomethylpyridinium)butane dibromide seems to be the most potent AChE reactivator.
K. Musílek +6 more
openaire +1 more source
AbstractNine potential AChE reactivators were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the previous results, 1,4-bis(2-hydroxyiminomethylpyridinium)butane dibromide seems to be the most potent AChE reactivator.
K. Musílek +6 more
openaire +1 more source