Ultra-Sensitive Analysis of Organophosphorus Compounds by Comparative GC-FPD and GC-ICP-MS: Implications for Chemical Warfare Agent Detection [PDF]
MoleculesOrganophosphorus chemical warfare agents such as sarin (GB), soman (GD), and cyclosarin (GF) rank among the most toxic substances known, making trace-level detection critical for public and military safety.
Michał Wiktorko +5 more
doaj +2 more sources
A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study [PDF]
Molecules, 2021 Organophosphorous nerve agents (OPNA) pose an actual and major threat for both military and civilians alike, as an upsurge in their use has been observed in the recent years.
Janek Bzdrenga +5 more
doaj +2 more sources
Counteracting poisoning with chemical warfare nerve agents [PDF]
Arhiv za Higijenu Rada i Toksikologiju, 2020 Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj +2 more sources
Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases [PDF]
BiomoleculesOlesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the blood–brain barrier, and has demonstrated excellent safety and tolerability properties in clinical research.
Dora Kolić +6 more
doaj +2 more sources
Effect of Seven Newly Synthesized and Currently Available Oxime Cholinesterase Reactivators on Cyclosarin-Intoxicated Rats [PDF]
, 2009 Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats.
Bajgar +33 more
core +6 more sources
New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics [PDF]
BiomoleculesNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus ...
Milena Mlakić +4 more
doaj +2 more sources
Benzyl trichloroacetimidates as derivatizing agents for phosphonic acids related to nerve agents by EI-GC-MS during OPCW proficiency test scenarios [PDF]
Scientific Reports, 2022 The use of benzyl trichloroacetimidates for the benzylation of phosphonic acid nerve agent markers under neutral, basic, and slightly acidic conditions is presented.
Alagu Subramanian +3 more
doaj +2 more sources
Cyclosarin-An Organophosphate Nerve Agent [PDF]
, 2005 Organophosphorus compounds ascribed to as nerve agents (sarin, soman, tabun, cyclosarin) are highly toxic, and are considered to be the most dangerous chemical compounds.
Krejcova, G., Kuca, K., Sevelova, L.
core +3 more sources
In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase [PDF]
Molecules, 2020 The implementation of the Chemical Weapons Convention (CWC) in 1997 was a milestone in the prohibition of chemical warfare agents (CWA). Yet, the repeated use of CWA underlines the ongoing threat to the population.
Franz Worek +3 more
doaj +2 more sources
Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. [PDF]
Chemistry, 2022 Rational design of efficient antidotes to organophosphorus nerve agent (OPNA) intoxication needs to account for the complexity of the molecular system. A fragment with broad‐spectrum binding profile was transformed into a multi‐active reactivator of OPNAs‐inhibited acetylcholinesterases.
Lindgren C +9 more
europepmc +2 more sources