Results 21 to 30 of about 1,092 (168)

Acetylcholinesterase: Structure, dynamics, and interactions with organophosphorus compounds. [PDF]

Protein Sci
Abstract Acetylcholinesterase (AChE) is an enzyme that hydrolyzes the neurotransmitter acetylcholine (ACh), removing it from the synaptic cleft after the transmission of an electrical signal, making it an essential component of chemical neurotransmission. AChE is a serine hydrolase, containing a catalytic triad of Ser/His/Glu.
Hung LW, Sanbonmatsu KY, Williams RF, Chen JC.   +3 more
europepmc   +2 more sources

Substrate Analogues for the Enzyme-Catalyzed Detoxification of the Organophosphate Nerve Agents-Sarin, Soman, and Cyclosarin. [PDF]

Biochemistry, 2021
Bigley AN, Harvey SP, Narindoshvili T, Raushel FM.   +3 more
europepmc   +3 more sources

Engineering Enzymes for Environmental Sustainability

Angewandte Chemie, Volume 135, Issue 52, December 21, 2023., 2023
This review highlights how engineered enzymes have been developed and implemented to help address environmental challenges. Topics include the use of engineered enzymes for improving carbon capture and utilisation, bioremediation, plastic deconstruction, and renewable feedstock generation.
Emily Radley, John Davidson, Jake Foster, Richard Obexer, Elizabeth L. Bell, Anthony P. Green   +5 more
wiley   +2 more sources

Chemical Weapons in the Iran-Iraq War (1980-1988) Iraq Preparing for Chemical War

Вестник войск РХБ защиты, 2023
The Iraqis became the first nation to use chemical weapons on the modern battlefield during the IranIraq War (1980-1988). There are no general reviews and research available on this issue in Russian.
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source

Chemical Weapons in the Iran-Iraq War (1980–1988) 3. Medical Consequences of Chemical Warfare

Вестник войск РХБ защиты, 2023
The third article in the series is dedicated to the medical consequences of the chemical warfare between Iran and Iraq during the war (1980–1988). The UN official documents and materials, declassified CIA documents, as well as other open Western and ...
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source

Chemical Weapons in the Iran-Iraq War (1980–1988). 6. Accumulated Experience in the Treatment of Lesions with Poisonous Nerve Agents

Вестник войск РХБ защиты, 2023
The Iran-Iraq war (1980–1988) was the first modern war in which chemical weapons were used. The purpose of this work is to summarize the experience of treating victims, affected by nerve agents. The publications of Iranian authors in different scientific
M. V. Supotnitskiy
doaj   +1 more source

Chemical Weapons in the Iran-Iraq War (1980–1988). 2. Combat Use of Chemical Weapons

Вестник войск РХБ защиты, 2023
The Iran-Iraq war (1980–1988) was the result of the geopolitical situation in the Middle East after the Islamic revolution in Iran in 1979. Certain longstanding territorial disputes and the absence of mutually recognized state border between the rivalry ...
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source

Phosphonylated tyrosine and lysine residues as biomarkers of local exposure of human hair to the organophosphorus nerve agents sarin and VX

Drug Testing and Analysis, Volume 15, Issue 7, Page 730-744, July 2023., 2023
This is the first report addressing analysis of biomarker adducts obtained from human hair exposed to the nerve agents sarin and VX in vitro. Phosphonylated single amino acids were obtained after pronase‐catalyzed proteolysis of hair proteins. Adducted Lys and especially Tyr residues were the most prominent adducts detected by μLC‐ESI MS/HR MS.
Harald John, Tamara Lindl, Henrik Reuter, Wolfgang Schmeißer, Michael Schrader, Horst Thiermann   +5 more
wiley   +1 more source

Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus

Epilepsia Open, Volume 8, Issue 2, Page 399-410, June 2023., 2023
Abstract Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences in brains postexposure have been reported.
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy   +6 more
wiley   +1 more source

Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness

Journal of Cellular and Molecular Medicine, Volume 27, Issue 7, Page 891-905, April 2023., 2023
Abstract Gulf War Illness (GWI) has been reported in 25%–35% of veterans returned from the Gulf war. Symptoms of GWI are varied and include both neurological and gastrointestinal symptoms as well as chronic fatigue. Development of GWI has been associated with chemical exposure particularly with exposure to pyridostigmine bromide (PB) and permethrin ...
Elise Slevin, Sachiko Koyama, Kelly Harrison, Ying Wan, James E. Klaunig, Chaodong Wu, Ashok K. Shetty, Fanyin Meng   +7 more
wiley   +1 more source