Results 61 to 70 of about 1,092 (168)
Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention [PDF]
, 2019 One quarter of veterans returning from the 1990–1991 Persian Gulf War have developed Gulf War Illness (GWI) with chronic pain, fatigue, cognitive and gastrointestinal dysfunction. Exertion leads to characteristic, delayed onset exacerbations that are not
Baraniuk, James N. +6 more
core +2 more sources
ChemPlusChem, Volume 89, Issue 8, August 2024.Fast and reliable detection of Nerve Agents (NAs) in the environment still represent an urgent need in emergency situation. The development of practical, portable sensing technology, accessible to non‐specialized operators, performing fast detection of NAs, still represents a challenge.
Roberta Puglisi +3 more
wiley +1 more source
Systematic comparison of different techniques to measure hippocampal subfield volumes in ADNI2 [PDF]
, 2018 OBJECTIVE: Subfield-specific measurements provide superior information in the early stages of neurodegenerative diseases compared to global hippocampal measurements.
Alpert, K +11 more
core +3 more sources
Supramolecular Approaches to the Detoxification of Nerve Agents
Israel Journal of Chemistry, Volume 64, Issue 6-7, July 2024.Abstract A promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but ...
Stefan Kubik
wiley +1 more source
Journal of Computational Chemistry, Volume 45, Issue 15, Page 1303-1315, June 5, 2024.Understanding the factors that lead to the formation of the bond between an organophosphorus, specifically chemical warfare agents, and AChE is essential for understanding these systems. This work used DFT techniques, such as AIM, NBO, and EDA, finding indications that this bond is driven by the pnictogen bond and, unlike the usual explanation that ...
Gustavo A. Andolpho +1 more
wiley +1 more source
Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults
Journal of Neurochemistry, Volume 168, Issue 4, Page 355-369, April 2024.We reviewed the current advances in our understanding of the effects of a variety of stressors in order to connect acute poisoning with organophosphates, neurotoxicity, changes in microRNAs, and transfer RNA fragments with cholinergic signaling dysfunction.
Zrinka Kovarik +3 more
wiley +1 more source
Oxidative Stress and Mitochondrial Injury in Chronic Multisymptom Conditions: From Gulf War Illness to Autism Spectrum Disorder [PDF]
, 2012 Background: Overlapping chronic multisymptom illnesses (CMI) include Chronic Fatigue Syndrome (CFS), fibromyalgia, irritable bowel syndrome, multiple chemical sensitivity, and Gulf War illness (GWI), and subsets of autism spectrum disorder (ASD).
Beatrice A. Golomb
core +1 more source
Solubilization and Humanization of Paraoxonase-1 [PDF]
, 2012 Paraoxonase-1 (PON1) is a serum protein, the activity of which is related to susceptibility to cardiovascular disease and intoxication by organophosphorus (OP) compounds.
Cerasoli, Douglas M. +8 more
core +2 more sources
Hydrolysis of G- and V-series organophosphorus nerve agents (OPNAs) containing a phosphorus-methyl bond yields a methylphosphonic acid (MeP) product when adducted to human butyrylcholinesterase (BChE).
core +3 more sources
Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats [PDF]
, 2008 The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun.
Bajgar +33 more
core +3 more sources