Rational Design and Directed Evolution of Human Paraoxonase I (huPON1) for Increased Solubility and Stability in E. coli [PDF]
, 2009 Paraoxonase I (PON1) is a serum hydrolase that has been found to hydrolyze organophosphates (OP), such as VX and sarin. Because human PON1 (huPON1) is a human protein with reasonable activity, it seems like a promising therapeutic agent against OP ...
Matic, George, Jr.
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Boron nitride nanoclusters as a sensor for Cyclosarin nerve agent: DFT and thermodynamics studies [PDF]
, 2020 Karim Derakhshan Karjabad +4 more
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Novel TRPA1 antagonist lead compound and its therapeutic potential in organophosphate poisoning
In Silico Research in BiomedicineOrganophosphate toxicity mediated by the TRPA1 ion channel presents a significant challenge in neurotoxicology. This study computationally explores a novel, potential inhibitory site within the TRPA1 channel pore, centered on the Serine 1039 residue ...
Shreya Satyanarayan Bhat +3 more
doaj +1 more source
Novel protein-based solutions for organophosphorus nerve agent detection and elimination [PDF]
, 2010 Organophosphorus (OP) nerve agents are some of the deadliest chemicals ever synthesized by man. These toxins, which include sarin, soman, cyclosarin, tabun, and VX, inhibit the neurotransmitter-regulating enzyme, acetylcholinesterase (AChE).
Hemmert, Andrew C.
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Ultrafast Spectroscopy And Computational Study Of The Photochemistry Of Diphenylphosphoryl Azide: Direct Spectroscopic Observation Of A Singlet Phosphorylnitrene [PDF]
, 2010 Mathematical and Physical Sciences: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)In order to characterize the active site of human paraoxonase 1 (HuPON1), photochemistry of a possible photoaffinity label diphenylphosphoryl
Vyas, Shubham
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Organophosphorus nerve agents (OPNAs) are toxic compounds that are classified as prohibited Schedule 1 chemical weapons. In the body, OPNAs bind to butyrylcholinesterase (BChE) to form nerve agent adducts (OPNA-BChE).
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Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents [PDF]
, 2008 Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, animmediate need is felt for the preparation of antidotes on large-scale basis.
Dolezal, Bohumil +5 more
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Butyrylcholinesterase genotype and enzyme activity in relation to Gulf War illness: preliminary evidence of gene-exposure interaction from a case¿control study of 1991 Gulf War veterans [PDF]
, 2015 Background Epidemiologic studies have implicated wartime exposures to acetylcholinesterase (AChE)-inhibiting chemicals as etiologic factors in Gulf War illness (GWI), the multisymptom condition linked to military service in the 1991 Gulf War.
Cook, Mary R +4 more
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A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats [PDF]
, 2007 Jiřı́ Kassa, Daniel Jun, Kamil Kuča
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Reactivation of Cyclosarin-inhibited Rat Brain Acetylcholinesterase by Pyridinium–Oximes [PDF]
, 2004 Kamil Kuča, Jiří Patočka
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