Results 11 to 20 of about 80,641 (196)

Cyclosporin a hepatotoxicity in 66 renal allograft recipients [PDF]

, 1981
Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. However, such presumed hepatotoxicity was a minor problem in the use of cyclosporin A.
Iwatsuki, S, Klintmalm, GBG, Starzl, TE
core   +1 more source

CYCLOSPORIN A IN THERAPY FOR JUVENILE ARTHRITIS

Современная ревматология, 2010
The paper describes approaches to using cyclosporin A (CsA) in juvenile arthritis (JA). It shows the benefits of combination basic therapy with CsA and methotrexate included into a treatment regimen mainly for systemic JA and JA involving the eye ...
E S Fedorov, Svetlana Olegovna Salugina
doaj   +1 more source

Effect of cyclosporine on hepatic energy status and on fructose metabolism after portacaval shunt in dog as monitored by phosphorus‐31 nuclear magnetic resonance spectroscopy in vivo [PDF]

, 1991
The effect of cyclosporin A on the hepatic energy status and intracellular pH of the liver and its response to a fructose challenge has been investigated using in vivo phosphorus‐31 nuclear magnetic resonance spectroscopy in dogs.
Atkinson, Avison, Baldassarri, Bode, Bäckman, Calne, Cohen, Evelhoch, Francavilla, Grant, Harder, Iles, Iles, Kahn, Kim, Kim, Klintmalm, Laupacis, Loertscher, Lorber, Makowka, Mazzaferro, Otte, Powles, Roos, Rossaro, Schade, Seo, Stacey, Starzl, Starzl, Starzl, Starzl, Starzl, Stone, Thompson, Van Thiel, Ziegler   +37 more
core   +1 more source

Stimulation of Tetrahydrobiopterin Synthesis by Cyclosporin A during Lipopolysaccharide Treatment in Vascular Endothelial Cells

Pteridines, 2002
We examined the effect of immunosuppressant cyclosporin A (CsA) on the synthesis of tetrahydrobiopterin (BH4), which is a cofactor for nitric oxide synthase (NOS), during treatment with lipopolysaccharide (LPS) in mouse brain microvascular endothelial ...
Ishii Masakazu, Shimizu Shunichi, Shiota Kazuhiro, Yamamoto Shinichiro, Kiuchi Yuji, Yamamoto Toshinori   +5 more
doaj   +1 more source

Lethal and Sublethal Toxicity Assessment of Cyclosporin C (a Fungal Toxin) against Plutella xylostella (L.)

Toxins, 2022
Secondary metabolites/toxins produced by Purpeocillium lilacinum (Hypocreales; Phiocordycipitaceae), a well-known insect pathogen, can be used for the management of different insect pests.
Jianhui Wu, Xiaochen Zhang, Muhammad Hamid Bashir, Shaukat Ali   +3 more
doaj   +1 more source

Pilot trial of fk 506 in the management of steroid-resistant nephrotic syndrome [PDF]

, 1993
Seven patients with steroid-resistant nephrotic syndrome were treated with FK 506 monotherapy. Four patients were children with focal sclerosing glomerulonephritis (FSGS).
Ellis, D, Igdal, H, McCalley, J, Shapiro, R, Shapiro, R, Starzl, TE, Starzl, TE, Starzl, TE, Tzakis, A, Tzakis, A   +9 more
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Pharmacokinetics of cyclosporin: a microemulsion in children with idiopathic nephrotic syndrome

Clinics, 2012
OBJECTIVE: We present a prospective study of a microemulsion of cyclosporin to treat idiopathic nephrotic syndrome in ten children with normal renal function who presented cyclosporin trough levels between 50 and 150 ng/ml and achieved complete remission
Luciana dos Santos Henriques, Fabíola de Marcos Matos, Maria Helena Vaisbich   +2 more
doaj   +1 more source

Effect of Terbinafine on the Pharmacokinetics of Cyclosporin in Humans [PDF]

, 1994
Cyclosporin is largely metabolized by hepatic cytochrome P450 enzymes, and azole drugs that inhibit cytochrome P450 may precipitate cyclosporin toxicity. The allylamine terbinafine binds to a small subfraction of hepatic cytochrome P450 in type I fashion,
Blankers, Matthijs, Busschbach, Jan J.V., Dekker, Jack J.M., Kikkert, Martijn J., Laurenssen, Elisabeth M.P., Luyten, Patrick, Peen, Jaap, Soons, Mirjam B.J., van Broekhuyzen, Anna J., van Dam, Anne Marie, Westra, Dieuwertje   +10 more
core   +2 more sources

Glucose homeostasis changes and pancreatic β-cell proliferation after switching to cyclosporin in tacrolimus-induced diabetes mellitus

Nefrología (English Edition), 2015
Background: Switching to cyclosporin A may result in a reversion of tacrolimus-induced diabetes mellitus. However, mechanisms underlying such a reversion are still unknown.
Ana Elena Rodríguez-Rodríguez, Javier Triñanes, Esteban Porrini, Silvia Velázquez-García, Cecilia Fumero, María Jose Vega-Prieto, María Luisa Díez-Fuentes, Sergio Luis Lima, Eduardo Salido, Armando Torres   +9 more
doaj   +1 more source

Systematic study of constitutive cyclo-oxygenase-2 expression: role of NFκB and NFAT transcriptional pathways [PDF]

, 2015
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs).
Ahmetaj-Shala, B, Berglund, LM, Chan, MV, Garcia-Vaz, E, Gomez, MF, Herschman, HR, Jiao, J, Kirkby, NS, Mitchell, JA, Verdu, EF, Wallace, JL, Zaiss, AK   +11 more
core   +1 more source