Results 181 to 190 of about 3,601 (247)

Investigating the production and release of cylindrospermopsin and deoxy-cylindrospermopsin by Cylindrospermopsis raciborskii over a natural growth cycle

Harmful Algae, 2014
Many harmful cyanobacterial genera have strains that can produce potent toxins and other biologically active compounds that present a risk to the health of humans and other animals that consume or contact contaminated water. Cylindrospermopsins (CYNs) are produced by several species of cyanobacteria including Cylindrospermopsis raciborskii (Woloszynska)
Michele Burford, Philip T Orr, Gregory Boyer   +2 more
exaly   +13 more sources

Biosynthesis of Cylindrospermopsin

The Journal of Organic Chemistry, 1999
Studies on the biosynthesis of cylindrospermopsin (1), a potent hepatotoxin associated with the cyanobacterium Cylindrospermopsis raciborskii, indicate that 1 is an acetogenin with guanidinoacetic acid serving as the starter unit of the polyketide chain. Feeding experiments show that C14 and C15 of 1 are derived from C1 and C2 of glycine, respectively,
D L, Burgoyne, T K, Hemscheidt, R E, Moore, M T, Runnegar   +3 more
openaire   +3 more sources

Combined-methods elucidate the multi-organ toxicity of cylindrospermopsin (CYN) on Daphnia magna.

Environmental Pollution, 2023
Global water bodies are now at risk from inevitable cyanobacterial blooms and their production of multiple cyanotoxins, in particular cylindrospermopsin (CYN).
Zhongshi He, You-Jen Chen, Da Huo, Jin Gao, Yewei Xu, Rui Yang, Yiming Yang, Gongliang Yu   +7 more
semanticscholar   +1 more source

First report on adverse effects of cyanobacterial anabaenopeptins, aeruginosins, microginin and their mixtures with microcystin and cylindrospermopsin on aquatic plant physiology: An experimental approach.

Toxicon, 2023
Cyanobacteria produce a variety of oligopeptides beyond microcystins and other metabolites. Their biological activities are not fully recognized especially to aquatic plants.
B. Pawlik-Skowrońska, A. Bownik, M. Pogorzelec, Justyna Kulczycka, Aleksandra Sumińska   +4 more
semanticscholar   +1 more source

A biomimetic approach to the cylindrospermopsin alkaloids

Chemical Communications, 2011
The tethered Biginelli condensation between hemiaminal 21 and β-keto ester 22 is reported, leading to a model tricyclic core of the cylindrospermopsin alkaloids.
Daniel M, Evans, Patrick J, Murphy
openaire   +2 more sources

The Cylindrospermopsin Alkaloids

2011
Abstract The cylindrospermopsin alkaloids are a family of structurally similar toxic natural products first encountered with the isolation of cylindrospermopsin from the cyanobacterium Cylindrospermopsis raciborskii , which was the causative agent in the poisoning of 148 inhabitants of Palm Island, Australia.
Daniel M, Evans, Patrick J, Murphy
openaire   +2 more sources

Syntheses of the cylindrospermopsin alkaloids

Tetrahedron, 2006
Abstract An intramolecular 1,3-dipolar cycloaddition has efficiently constructed the A-ring portions of the cylindrospermopsin alkaloids. A nitro-aldol addition of an elaborated nitroalkane to a pyrimidine aldehyde followed by an intramolecular reductive guanidinylation has enabled the syntheses of all three alkaloids in this family in 18–19 steps ...
Ryan E. Looper, Maria T.C. Runnegar, Robert M. Williams   +2 more
openaire   +1 more source

Effects of cyanobacterial metabolites: Aeruginosin 98A, microginin-FR1, anabaenopeptin-A, cylindrospermopsin in binary and quadruple mixtures on the survival and oxidative stress biomarkers of Daphnia magna.

Toxicon, 2023
The aim of our study was to determine the effects of aeruginosin 98 A (ARE-A), microginin-FR1 (MG-FR1), anabaenopeptin-A (ANA-A) cylindrospermopsin (CYL) and their binary and quadruple mixtures on the survival and the levels of oxidative stress ...
A. Bownik, M. Adamczuk, B. Skowrońska
semanticscholar   +1 more source

Total Synthesis of (±)-Cylindrospermopsin

Journal of the American Chemical Society, 2000
The first total synthesis of the novel hepatotoxin (±)-cylindrospermopson (1) has been accomplished in 20 steps from 4-methoxy-3-methylpyridine (12) in 3.5% overall yield. The substituted piperidine A ring 19 was generated stereospecifically by a four-step sequence using the addition of trimethylsilylethynylmagnesium bromide to 12 to give 16 and ...
Chaoyu Xie, Maria T. C. Runnegar, Barry B. Snider   +2 more
openaire   +1 more source

Cyanobacterial metabolites: aeruginosin 98A, microginin-FR1, anabaenopeptin-A, cylindrospermopsin and their mixtures affect behavioral and physiological responses of Daphnia magna.

Environmental Toxicology and Pharmacology, 2023
We determined the effects influence of cyanobacterial products metabolites: aeruginosin-A (AER-A), microginin-FR1 (MG-FR1), anabaenopeptin-A (ANA-A), cylindrospermopsin (CYL) and their binary and quadruple mixtures on swimming behavior, heart rate ...
A. Bownik, M. Adamczuk, B. Pawlik-Skowrońska, T. Mieczan   +3 more
semanticscholar   +1 more source