EKSPRESI GEN CYP19 AROMATASE,ESTROGEN, ANDROGEN PADAPENDERITA PERIODONTITIS AGRESIF
Kepadatan tulang tubuh ditentukan oleh gen CYP19 aromatase, hormon estrogen dan androgen. Pada periodontitis agresif terjadi perkembangan cepat kerusakan tulang alveolar,dan kerusakan tulang alveoler tersebut tidak diimbangioleh regenerasi tulang ...
Dahlia Herawati, Sri Kadarsih, Wayan T. Artama, dan Suryono
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Neonicotinoids Cause a Promoter-Switch of CYP19 Expression in Hs578t Breast Cancer Cells by Activating the VEGF-Signaling Pathways: What Are the Implications for Breast Cancer? [PDF]
Aromatase (CYP19) is a key enzyme in the biosynthesis of estrogen and is expressed in a promoter-specific manner. In the healthy mammary gland, CYP19 is expressed at low levels under the regulation of its I.4 promoter. In hormone-
Viau, Mélanie +2 more
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Menopause is a permanent cessation of menstrual cycle due to reduced secretion of the hormone estrogen which can result in osteoporosis. Osteoporosis is characterized by the process of bone resorption faster than the process of bone formation, resulting ...
Sri Widodo +2 more
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Correlation of CYP19 variants (CC vs AC + AA) to clinical characteristics.
1Two-sided χ2 test.Correlation of CYP19 variants (CC vs AC + AA) to clinical characteristics.
Yong Guo (169213) +9 more
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Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer [PDF]
In humans, aromatase (CYP19) gene expression is regulated via alternative promoters. Activation of each promoter gives rise to a CYP19 mRNA species with a unique 5′-untranslated region. Inhibition of aromatase has been reported to downregulate lung tumor
Demura, Yoshiki +21 more
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Background The phenomenon of chemotherapy-resistant cancers has necessitated the development of new therapeutics as well as the identification of specific prognostic markers to predict the response to novel drugs.
Anna A. Nushtaeva +10 more
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The association of aromatase (CYP19) gene variants with sperm concentration and motility
The irreversible transformation of androgens into oestrogens is catalysed by cytochrome P450 aromatase. In the present study, we explored the contribution of the (TTTA)(n) polymorphism in the aromatase gene (CYP19) to sperm concentration and motility. Ninety normozoospermic and 60 oligospermic men were examined during infertility examinations.
Lazaros, L. +7 more
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Zebrafish sex determination and differentiation: Involvement of FTZ-F1 genes
Sex determination is the process deciding the sex of a developing embryo. This is usually determined genetically; however it is a delicate process, which in many cases can be influenced by environmental factors.
Olsson Per-Erik, von Hofsten Jonas
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Genetic variant in the CYP19 gene and recurrent spontaneous abortions
Abstract Background The CYP19 gene encodes aromatase, a key cytochrome P450 enzyme that converts androgens to estrogens in the ovarian tissues of premenopausal women. A polymorphic variation C/T in the CYP19 gene, rs10046, results in modified estrogen levels through increasing aromatase activity.
Christina Koutsothanassis +5 more
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Sexing Frogs by Real-Time PCR: Using Aromatase (cyp19) as an Early Ovarian Differentiation Marker
Most anurans have no identified sex-markers; therefore, alternative methods for identification of early changes in sex ratios are required. In this study, Lithobates sylvaticus and Silurana tropicalis tadpoles were sampled at different developmental ...
Robertson, C. +6 more
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