Results 221 to 230 of about 34,953 (257)

CYP1A1.

IARC scientific publications, 1999
CYP1A1 plays an important role in the metabolism of polycyclic hydrocarbons that occur in the environment and several studies suggest that the genetic polymorphism of the gene may play a role in the predisposition to cancer. In order to evaluate the function of CYP1A1 in vivo as a host factor determinant of environmentally-caused cancers in humans ...
openaire   +1 more source

Expression of CYP1A1 and CYP1A2 genes in human liver

Pharmacogenetics, 1993
Immunoblot analysis of human livers using a monospecific antibody to rat CYP1A2 section demonstrated that the expression of CYP1A2 protein is highly variable in human liver. Quantitative PCR analysis was then employed to examine the interindividual variability of both CYP1A1 and CYP1A2 mRNAs in human liver.
H, Schweikl, J A, Taylor, S, Kitareewan, P, Linko, D, Nagorney, J A, Goldstein   +5 more
openaire   +2 more sources

Genetic polymorphism of induction of CYP1A1 (EROD) activity

Pharmacogenetics, 1995
CYP1A1 is a cytochrome P450 which is inducible by polycyclic aromatic hydrocarbons (PAH). This induction is mediated via the Ahr locus which encodes the cytosolic Aryl hydrocarbon receptor. The induced activity of CYP1A1 can be measured in vitro by the ethoxyresorufin-O-deethylase (EROD) activity in lymphocytes after induction by benz(a)anthracene (B(a)
A, Catteau, E, Douriez, P, Beaune, N, Poisson, C, Bonaiti-Pellié, P, Laurent   +5 more
openaire   +2 more sources

cDNA cloning and characterization of feline CYP1A1 and CYP1A2

Life Sciences, 2006
Deficiency of drug glucuronidation in the cat is one of the major reasons why this animal is highly sensitive to the side effects of drugs. The characterization of cytochrome P450 isoforms belonging to the CYP1A subfamily, which exhibit important drug oxidation activities such as activation of pro-carcinogens, was investigated.
Nagako, Tanaka, Taku, Miyasho, Raku, Shinkyo, Toshiyuki, Sakaki, Hiroshi, Yokota   +4 more
openaire   +2 more sources

Serum increases CYP1A1 induction by 3-methylcholanthrene

Biochemical and Biophysical Research Communications, 2002
CYP1A1 is largely involved in carcinogenesis through the bioactivation of numerous procarcinogens. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. We have previously demonstrated that fetal bovine serum (FBS) induces CYP1A1 gene transcription.
Quoc-Binh, N'Guyen, Frederique, Fallone, Eric, Seree, Frederic, Fina, Pierre-Henri, Villard, Nolwen, Guigal, Michel, De Meo, Bruno, Lacarelle, Pierre-Marie, Martin, Yves, Barra   +9 more
openaire   +2 more sources

Analysis of CYP1A1 promoter function by transcription in vitro

Molecular Carcinogenesis, 1991
AbstractWe have analyzed the function of the CYP1A1 promoter using in vitro transcription. Using nuclear extracts from HeLa cells, we found that transcription from the promoter in vitro was constitutive. Transcription in vitro was not increased by prior exposure of the HeLa cells to the inducer 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin nor by the inclusion ...
L P, Wen, K W, Jones, J P, Whitlock
openaire   +2 more sources

CYP1A1 polymorphism and risk of gynecological malignancy in Japan

International Journal of Gynecological Cancer, 2003
The incidence of endometrial cancer and ovarian cancer in Japan has been increasing in recent years. Results of epidemiologic studies suggest that the onset and multiplication of these cancers are associated with estrogen. Estrogens are metabolized by cytochrome P450 1A1 (CYP1A1) and converted into catecholestrogens, which are carcinogens.
T, Sugawara, E, Nomura, T, Sagawa, N, Sakuragi, S, Fujimoto   +4 more
openaire   +2 more sources

Rat hepatic CYP1A1 and CYP1A2 induction by menadione

Toxicology Letters, 2005
The effects of menadione on activities and expression of cytochrome P450 (CYP) 1A subfamily (CYP1A) isozymes in rat hepatic tissue were examined. When rats were treated orally with 15 mg/kg menadione for 4 days, the elevation of hepatic CYP1A1/1A2 specific activities in microsomal preparations was detected with approximately 5.4- and 2.5-fold increase ...
Y A, Sidorova, A Y, Grishanova, V V, Lyakhovich   +2 more
openaire   +2 more sources

CYP1A1: Friend or Foe?

Drug Metabolism Reviews, 1993
openaire   +2 more sources

Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells

Biochemistry (Moscow), 2018
B. Huang, J. Bao, Yaru Cao, Huifang Gao, Yong Jin   +4 more
semanticscholar   +1 more source