Results 201 to 210 of about 34,953 (257)

Human CYP1A1 inhibition by flavonoids

Toxicology in Vitro, 2020
Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene. Several authors had proposed CYP1A inhibition as a plausible strategy for cancer chemoprevention.
Rebeca, Santes-Palacios, Ana L, Marroquín-Pérez, Sandra L, Hernández-Ojeda, Rafael, Camacho-Carranza, Tzipe, Govezensky, J Javier, Espinosa-Aguirre   +5 more
openaire   +2 more sources

Dietary Ellagic Acid Inhibits the Enzymatic Activity of CYP1A1 without Altering Hepatic Concentrations of CYP1A1 or CYP1A1 mRNA

Biochemical and Biophysical Research Communications, 1994
The anticarcinogen ellagic acid significantly reduces the incidence of polycyclic aromatic hydrocarbon induced carcinomas, in association with significant reductions in benzo[a]pyrene hydroxylase activity and CO reducible hepatic cytochrome P450. This suggested that ellagic acid reduced hepatic concentrations of CYP1A1, but these changes occurred ...
D H, Barch, L M, Rundhaugen, P E, Thomas, P, Kardos, N S, Pillay   +4 more
openaire   +2 more sources

Ambient fine particulate matter (PM2.5) induces oxidative stress and pro-inflammatory response via up-regulating the expression of CYP1A1/1B1 in human bronchial epithelial cells in vitro.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2019
We investigated the mechanism responsible for the oxidative stress and pro-inflammatory response triggered by PM2.5 collected from Nanjing of China. Two human bronchial epithelia cell lines (HBE and BEAS-2B) were used.
Qi Yuan, Yaoyao Chen, Xiao-Bo Li, Zheng-Dong Zhang, H. Chu   +4 more
semanticscholar   +1 more source

CYP1A1, smoking and venous thromboembolism

Thrombosis and Haemostasis, 2010
SummarySince CYP1A1 enzyme is involved in metabolism of tobacco carcinogens, the CYP1A1 gene may be of relevance to smoking-induced differences in the risks of venous thromboembolism (VTE). We conducted a case-control study to investigate genetic polymorphisms in CYP1A1 that might modify the risk of developing VTE.
Jin, Zhu, Wen-Jie, Zheng, Fan-Cui, Kong, Wei-Juan, Zhang, He-Yao, Wang, Chen, Wang   +5 more
openaire   +2 more sources

Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options.

Pharmacology and Therapeutics, 2018
The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its oxidative metabolism of benzo[a]pyrene and related polycyclic aromatic hydrocarbons ...
M. Mescher, T. Haarmann-Stemmann
semanticscholar   +1 more source

The CYP1A1 gene and cancer susceptibility

Critical Reviews in Oncology/Hematology, 1993
A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose.
K, Kawajiri, K, Nakachi, K, Imai, J, Watanabe, S, Hayashi   +4 more
openaire   +2 more sources

Regulation of CYP1A1 expression

The FASEB Journal, 1992
CYP1A1 is considered to be involved mainly in oxidative metabolism of exogenous chemicals and drugs. Synthesis of this hemoprotein is induced in livers, lungs, and other tissues of experimental animals by the administration of these chemicals.
Y, Fujii-Kuriyama, H, Imataka, K, Sogawa, K, Yasumoto, Y, Kikuchi   +4 more
openaire   +2 more sources

Polychlorinated diphenyl sulfides can induce ROS and genotoxicity via the AhR-CYP1A1 pathway.

Chemosphere, 2019
Polychlorinated diphenyl sulfides (PCDPSs) are a group of chemicals that can interact and activate the aryl hydrocarbon receptor (AhR). Previous studies have shown that PCDPSs can cause oxidative stress in livers.
Hong-Ling Liu, Laihao Shi, J. Giesy, Hong-Xia Yu   +3 more
semanticscholar   +1 more source

Effect of troglitazone on CYP1A1 induction

Toxicology, 2008
Several peroxisome proliferators enhance CYP1A1 activity, but the mechanisms involved in this enhancement remain unknown. In this study, we examined the effect of troglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, on CYP1A1 gene expression and explored the mechanisms involved in these effects.
Hyung Gyun, Kim, Eun Hee, Han, Hye Gwang, Jeong   +2 more
openaire   +2 more sources

Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms

Pharmacogenetics, 2000
The genotypic basis of interindividual variation in levels of induced CYP1A1 activity has been investigated by screening both the CYP1A1 gene and the Ah receptor gene (AhR) for both previously described and novel polymorphisms. A 103-fold level of interindividual variation in induced CYPlA1 activity [ethoxyresorufin O-deethylase (EROD)] was observed in
J, Smart, A K, Daly
openaire   +3 more sources