CYP27A1 deficiency promoted osteoclast differentiation [PDF]
PeerJ, 2023 Background The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but
Ziqi Fang +3 more
doaj +6 more sources
On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1 [PDF]
Journal of Lipid Research, 2013 The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.
Zeina Ali +9 more
doaj +8 more sources
NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss [PDF]
FASEB BioAdvancesThis study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function.
Bohao Li +9 more
doaj +5 more sources
TUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1 [PDF]
Cell Death and Disease, 2023 Cholesterol metabolism plays a critical role in the progression of hepatocellular carcinoma (HCC), but it is not clear how cholesterol metabolism is regulated.
Xiaobo Wang +8 more
doaj +5 more sources
Heterozygous CYP27A1 gene mutation presenting with Achilles tendon xanthoma: a case report [PDF]
Journal of Medical Case ReportsBackground Cerebrotendinous xanthomatosis is a rare autosomal recessive lipid storage disorder involving bile acid biosynthesis. Reduced mitochondrial cytochrome P450 enzyme activity leads to abnormal lipid accumulation in various tissues, especially ...
Yushi Oyama +5 more
doaj +5 more sources
CYP27A1 suppresses brain metastasis via ferroptosis in lung adenocarcinoma: a six-gene signature predicting the immunotherapy response and clinical outcomes [PDF]
Cancer Cell InternationalBackground: Lung adenocarcinoma (LUAD) brain metastasis has limited therapeutic options and a poor prognosis. This study aimed to identify molecular drivers, construct a prognostic model, and assess immunotherapy response.
Lu Xu +4 more
doaj +3 more sources
Genetic Polymorphism of <i>CYP2R1</i>, <i>CYP27A1</i>, <i>CYP27B1</i>, and Vitamin D Metabolites Plasma Levels in Patients with Cardiovascular Disease: A Pilot Study. [PDF]
BiomoleculesThe active form of vitamin D, calcitriol (1,25(OH)2D3), is produced from 25(OH)D3 via enzymes encoded by CYP2R1, CYP27A1, and CYP27B1. Polymorphisms in these genes may alter vitamin D metabolism and increase cardiovascular disease risk.
Abouzid M +8 more
europepmc +4 more sources
Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure [PDF]
Advanced SciencePrenatal dexamethasone exposure (PDE) can impact adrenal corticosteroid synthesis in adult offspring. Furthermore, the adrenal gland can autonomously synthesize bile acids, but local bile acids accumulation has cytotoxic effects.
Jiangang Cao +7 more
doaj +3 more sources
Molecular Therapy: Methods & Clinical Development, 2021 Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by mutations in the CYP27A1 gene, encoding the sterol 27-hydroxylase. Disruption of the bile acid biosynthesis pathway and accumulation of toxic precursors such as cholestanol ...
Sara Lumbreras +12 more
doaj +3 more sources
BMC Immunology, 2023 Background The association between lipid metabolism disorder and carcinogenesis is well-established, but there is limited research on the connection between lipid metabolism-related genes (LRGs) and lung adenocarcinoma (LUAD).
Yi Yin +3 more
doaj +2 more sources