Results 1 to 10 of about 9,202 (195)

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1 [PDF]

Journal of Lipid Research, 2013
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.
Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem   +9 more
doaj   +7 more sources

Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet [PDF]

Frontiers in Nutrition
BackgroundATP-binding cassette subfamily A1 (ABCA1) and sterol 27-hydroxylase (CYP27A1) are essential regulators of cholesterol metabolism. However, their tissue-specific roles, particularly in the lung, under high-cholesterol diet (HCD) conditions ...
Jian Ma, Jian Ma, Zhongwen Gong, Hong Lu, Han Yang, Shengquan Wang, Qian Zhu, Hongya Liu, Yongjia Li, Yuemei Zhang, Xuemei Lian, Xuemei Lian   +11 more
doaj   +2 more sources

CYP27A1 suppresses brain metastasis via ferroptosis in lung adenocarcinoma: a six-gene signature predicting the immunotherapy response and clinical outcomes [PDF]

Cancer Cell International
Background: Lung adenocarcinoma (LUAD) brain metastasis has limited therapeutic options and a poor prognosis. This study aimed to identify molecular drivers, construct a prognostic model, and assess immunotherapy response.
Lu Xu, Liyou Huang, Zihao Liu, Xiaojie Jiang, Linchun Wen   +4 more
doaj   +2 more sources

Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer [PDF]

Frontiers in Immunology
BackgroundThe response rate to immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC) varies significantly among individuals. Cancer-associated macrophages (TAMs) are key components of the tumor immune microenvironment (TIME), influencing
Qingsheng Liu, Xufeng Liu, Han Zhang, Yuhang Jiang, Ying Shi, Qiuqiao Mu, Yuhao Jing, Daqiang Sun   +7 more
doaj   +2 more sources

Heterozygous CYP27A1 gene mutation presenting with Achilles tendon xanthoma: a case report [PDF]

Journal of Medical Case Reports
Background Cerebrotendinous xanthomatosis is a rare autosomal recessive lipid storage disorder involving bile acid biosynthesis. Reduced mitochondrial cytochrome P450 enzyme activity leads to abnormal lipid accumulation in various tissues, especially ...
Yushi Oyama, Keishiro Okawa, Takuya Miyagi, Takahiro Sakai, Kyuhachi Otagiri, Hiroshi Kitabayashi   +5 more
doaj   +2 more sources

2 Novel deletions of the sterol 27-hydroxylase gene in a Chinese Family with Cerebrotendinous Xanthomatosis [PDF]

BMC Neurology, 2011
Background Cerebrotendinous xanthomatosis (CTX) is a rare lipid-storage disease. We investigated the clinic manifestation, histopathology and sterol 27-hydroxylase gene (CYP27A1) in a Chinese family with Cerebrotendinous Xanthomatosis (CTX).
Tian Di, Zhang Zai-qiang
doaj   +4 more sources

Genetic variants in the vitamin D pathway genes are predictors of the risk of diabetic kidney disease in Central Asian Kazakhstani cohort with type 2 diabetes [PDF]

Frontiers in Medicine
IntroductionDiabetic kidney disease (DKD) is a common microvascular complication of type 2 diabetes mellitus (T2DM). Given vitamin D’s roles in glucose metabolism and renal function, this study investigated associations between common variants in vitamin
Binura Taurbekova, Abay Tursunov, Aida Kabibulatova, Alimzhan Muxunov, Assel Issabayeva, Kuralay Atageldiyeva, Kuralay Atageldiyeva, Kamilya Sydykova, Aigul Durmanova, Akbayan Markabayeva, Andrey Starodubov, Kymbat Mukhtarova, Wassim Y. Almawi, Antonio Sarria-Santamera   +13 more
doaj   +2 more sources

NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss [PDF]

FASEB BioAdvances
This study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function.
Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang   +9 more
doaj   +2 more sources

Cholesterol‐27α‐hydroxylase inhibitor nilvadipine can effectively treat cholestatic liver injury in adult offspring induced by prenatal dexamethasone exposure [PDF]

MedComm
Prenatal dexamethasone exposure (PDE) can increase offspring susceptibility to various diseases. However, the pathogenesis and early prevention for PDE offspring prone to cholestatic liver injury have been unclear.
Wen Hu, Jiayong Zhu, Qi Zhang, Xiaoqian Lu, Luting Yu, Bin Li, Liaobin Chen, Hui Wang   +7 more
doaj   +2 more sources

Molecular dynamics, docking and quantum calculations reveal conformational changes influenced by CYP271A amino acid mutations related to cerebrotendinous xanthomatosis [PDF]

Scientific Reports
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid disorder caused by a deficiency in CYP27A1, the first enzyme in the bile acid biosynthesis pathway.
Yudibeth Sixto-López, Humberto L. Mendoza-Figueroa, Bruno Landeros-Rivera, Alejandra Camacho-Molina, José Correa-Basurto   +4 more
doaj   +2 more sources