Results 11 to 20 of about 9,202 (195)

CYP27A1 deficiency promoted osteoclast differentiation [PDF]

PeerJ, 2023
Background The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but
Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin   +3 more
doaj   +4 more sources

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine [PDF]

Journal of Lipid Research, 2007
Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li, Wenling Chen, John Y.L. Chiang   +2 more
doaj   +3 more sources

On the substrate specificity of human CYP27A1 [PDF]

Journal of Lipid Research, 2003
The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin, Sara von Bahr, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +2 more sources

TUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1

Cell Death and Disease, 2023
Cholesterol metabolism plays a critical role in the progression of hepatocellular carcinoma (HCC), but it is not clear how cholesterol metabolism is regulated.
Xiaobo Wang, Jiawei Shi, Mingming Huang, Jiehong Chen, Jia Dan, Yunhua Tang, Zhiyong Guo, Xiaoshun He, Qiang Zhao   +8 more
doaj   +3 more sources

Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia[S] [PDF]

Journal of Lipid Research, 2017
Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD.
Hiten D. Mistry, Lesia O. Kurlak, Yosef T. Mansour, Line Zurkinden, Markus G. Mohaupt, Geneviève Escher   +5 more
doaj   +5 more sources

Clinical and genetic analysis of a family with cerebrotendinous xanthomatosis [PDF]

Frontiers in Neurology
ObjectiveThis study aims to analyze the clinical and genetic characteristics of cerebrotendinous xanthomatosis (CTX) in a Chinese family.MethodsClinical data, including medical history, neurologic and auxiliary examinations, imaging studies, and genetic ...
You Guoliang, Wang Zhaoxia, Zhang Lin, Chen Xuan, Zhang Xiaodong, Xing Xiaolian, Su Yangli, Zhang Tianli, Zhu Yanping, Wang Jiangping, Liu Qing   +10 more
doaj   +2 more sources

Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure [PDF]

Advanced Science
Prenatal dexamethasone exposure (PDE) can impact adrenal corticosteroid synthesis in adult offspring. Furthermore, the adrenal gland can autonomously synthesize bile acids, but local bile acids accumulation has cytotoxic effects.
Jiangang Cao, Wen Hu, Yawen Chen, Aihemaitijiang Ailikaiti, Ziyi Zhang, Lingbo Rong, Hong Yu, Hui Wang   +7 more
doaj   +2 more sources

Optimization of CYP27A1 recombinant protein expression. [PDF]

Protein Expr Purif
Papa JE, Vaughn LR, Bartholomew-Schoch JL, Stone EK, Culpepper MA, Reddish MJ.   +5 more
europepmc   +3 more sources

Molecular cloning, expression analysis and functional characterization of chicken cytochrome P450 27A1: A novel mitochondrial vitamin D3 25-hydroxylase

Poultry Science, 2023
: Vitamin D3 is hydroxylated by cytochrome P450 (CYP) before exerting biological effects. The chicken CYP involved in vitamin D3 25-hydroxylation has yet to be cloned, and little is known about its functional characteristics, tissue distribution, and ...
S. Shang, Z. He, W. Hou, X. Chen, X. Zhao, H. Han, S. Chen, S. Yang, F. Tai   +8 more
doaj   +1 more source

Metabolism of Lumisterol2 by CYP27A1

The Journal of Steroid Biochemistry and Molecular Biology, 2023
Lumisterol2 (L2) is a photoproduct of UVB action on the fungal membrane sterol, ergosterol. Like vitamin D2, it is present in edible mushrooms, especially after UV irradiation. Lumisterol3 is similarly produced in human skin from 7-dehydrocholesterol by UVB and can be converted to hydroxy-metabolites by CYP27A1 and CYP11A1.
Dongxian, Wu, Gareth, Nealon, Yuchen, Liu, Tae-Kang, Kim, Andrzej T, Slominski, Robert C, Tuckey   +5 more
openaire   +2 more sources