Results 21 to 30 of about 9,202 (195)
BMC Immunology, 2023 Background The association between lipid metabolism disorder and carcinogenesis is well-established, but there is limited research on the connection between lipid metabolism-related genes (LRGs) and lung adenocarcinoma (LUAD).
Yi Yin +3 more
doaj +1 more source
Breast Cancer Research, 2020 Background 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice.
Siker Kimbung +10 more
doaj +1 more source
Activity of 25-hydroxylase in human gingival fibroblasts and periodontal ligament cells. [PDF]
PLoS ONE, 2012 We previously demonstrated that 25-hydroxyvitamin D(3) concentrations in gingival crevicular fluid are 300 times higher than those in the plasma of patients with aggressive periodontitis. Here we explored whether 25-hydroxyvitamin D(3) can be synthesized
Kaining Liu, Huanxin Meng, Jianxia Hou
doaj +1 more source
CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer [PDF]
Cancer Research, 2017 Abstract In this study, we used a bioinformatic approach to identify genes whose expression is dysregulated in human prostate cancers. One of the most dramatically downregulated genes identified encodes CYP27A1, an enzyme involved in regulating cellular cholesterol homeostasis.
Mahmoud A, Alfaqih +13 more
openaire +2 more sources
Host CYP27A1 expression is essential for ovarian cancer progression [PDF]
Endocrine-Related Cancer, 2019 There is an urgent need for more effective strategies to treat ovarian cancer. Elevated cholesterol levels are associated with a decreased progression-free survival time (PFS) while statins are protective. 27-Hydroxycholesterol (27HC), a primary metabolite of cholesterol, has been shown to modulate the activities of the estrogen receptors (ERs) and ...
Sisi, He +8 more
openaire +2 more sources
Cerebrotendinous xanthomatosis: recurrence of the CYP27A1 mutation p.Arg479Cys in Sardinia [PDF]
Neurological Sciences, 2014 Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder, due to mutations of the CYP27A1 gene, leading to cholestanol accumulation because of the sterol27-hydroxylase enzyme deficiency [1]. Treatment with chenodeoxycholic acid (CDCA) normalizes cholestanol and improves neurophysiological findings.
Mandrile G +9 more
openaire +5 more sources
Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]
, 2019 Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria +4 more
core +1 more source
27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor
Journal of Lipid Research, 2023 Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha-positive breast cancer (ER(+) BC) and triple-negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from cholesterol:
Silia Ayadi +7 more
doaj +1 more source
Vitamin D enzymes (CYP27A1, CYP27B1 and CYP24A1) and receptor expression in non-melanoma skin cancer [PDF]
, 2019 No abstract available for this ...
Apostolopoulos, Vasso +4 more
core +2 more sources
Molecular Therapy: Methods & Clinical Development, 2021 Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by mutations in the CYP27A1 gene, encoding the sterol 27-hydroxylase. Disruption of the bile acid biosynthesis pathway and accumulation of toxic precursors such as cholestanol ...
Sara Lumbreras +12 more
doaj +1 more source